A5101714161- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Drug-Induced Hepatotoxicity and Protection
- Plant Toxicity and Pharmacological Properties
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Surgical Treatments
- FOXO transcription factor regulation
- Poisoning and overdose treatments
- RNA Interference and Gene Delivery
- Tuberculosis Research and Epidemiology
- Glutathione Transferases and Polymorphisms
- RNA Research and Splicing
- NF-κB Signaling Pathways
- Bioactive Compounds and Antitumor Agents
- Animal Virus Infections Studies
- Gastric Cancer Management and Outcomes
Xi’an International University
2024
Huazhong University of Science and Technology
2008-2020
Tongji Hospital
2012-2020
First Affiliated Hospital of Zhengzhou University
2019-2020
Zaozhuang Municipal Hospital
2018
Union Hospital
2016
Wenzhou Medical University
2015
University of North Carolina at Chapel Hill
2005
MiR-93 was observed in various types of cancers. This study is to investigate a role miR-93 the carcinogenesis HCC.The expression HepG2 cells and prima-ry human hepatocytes (PHHC) measured by RT-PCR. were transfected with inhibitor or negative control. The cell proliferation determined using CellTiter 96® Aqueous One Solution Cell Proliferation Assay kit. migration clonogenicity vitro assay, colony formation analysis anchorage-in-dependent growth assay. apoptosis cycle detected flow...
// Xiaokun Shen 1,2,* , Bojian Xie 1,* Zhaosheng Ma Wenjie Yu 1 Wenmin Wang Dong Xu Xinqiang Yan Beibei Chen 3 Longyao 4 Jicheng Li 2 Xiaobing Kan Ding and Feilin Cao Department of Surgical Oncology, Taizhou Hospital, Wenzhou Medical University, Taizhou, Zhejiang, China Institute Cell Biology, Zhejiang Hangzhou, Internal Hennan Cancer The Affiliated Hospital Zhengzhou Zhengzhou, Hennan, Glycobiology Glycochemistry Lab, Shanghai Materia Medica, Chinese Academy Sciences, Shanghai, * These...
Aberrant expressions of long non-coding RNAs (lncRNAs) are the culprits carcinogenesis via regulating tumor suppressor or oncogene. LncRNA nuclear enriched abundant transcript 1 (NEAT1) has been identified to be an oncogene promote growth and metastasis many cancers. However, clinical significance function NEAT1 in osteosarcoma (OS) remain discovered. We here collected OS tissues (n=40) adjacent non-tumor (n=20) determine expression its significance. was overexpressed tissues, which...
microRNAs (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Several miRNAs associated with the development hepatocellular carcinoma (HCC). miR-96 has been closely cell proliferation clonogenicity. Upregulation observed in various types cancer. However, biological hepatocarcinogenesis remains largely unknown. In this study, we demonstrated that was upregulated HCC inhibition significantly suppressed colony formation. The levels forkhead...
Long noncoding RNAs (lncRNAs) exert key regulators in cancer development and progression. The functional significance of lncRNA small nucleolar RNA host gene 20 (SNHG20) was reported gastric (GC); however, the underlying molecular mechanism GC is largely unknown. Here, our results showed that SNHG20 expression significantly higher tissues compared with adjacent normal by quantitative real-time PCR (qRT-PCR) analysis. Higher highly associated tumor size lymphatic metastasis patients. Patients...
Introduction Lymph node metastasis is a crucial determinant of prognosis in colorectal cancer (CRC), significantly impacting survival outcomes and treatment decision-making. This study aims to evaluate the prognostic value tumor infiltration proportion within lymph nodes (TIPLN) N1 CRC patients develop TIPLN-based nomogram predict prognosis. Methods A total 416 who underwent radical resection were enrolled divided into training validation cohorts. Whole-slide images annotated assess TIPLN....
One major etiology of hepatic sinusoidal obstruction syndrome (HSOS) in China is the intake pyrrolizidine alkaloids (PAs). Since PAs-induced HSOS a rare disease that has not been clearly characterized until now, aim this study was to investigate clinical characteristics, CT features, and pathological findings PA-induced HSOS.This retrospective cohort included 116 patients with 68 Budd-Chiari from Jan 2006 Sep 2016. We collected medical records patients, reviewed image features CT, analyzed...
MicroRNAs (miRNAs/miRs) are a class of small noncoding RNA molecules that have important roles in regulating the expression target genes associated with development and progression cancer. The majority miRNAs expressed highly tissue- region-specific manner, released into bloodstream as consequences different diseases. Furthermore, altered levels been observed several diseases, including In present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated...
Background: Cholangiocarcinoma (CCA) is a serious malignant tumor.Long non-coding RNA NNT-AS1 (NNT-AS1) takes crucial roles in several tumors.So, we planned to research the and underlying mechanism of CCA.Results: overexpression was appeared CCA tissues cell lines.Proliferation promoted by CCLP1 TFK1 cells.Besides, reduced E-cadherin level raised levels N-cadherin, vimentin, Snail Slug.However, opposite trend occurred knockdown.Further, phosphatidylinositol 3 kinase (PI3K)/AKT extracellular...
Human uveal melanoma (UM) is a common ocular malignant tumor with high risk of metastasis. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are correlated the development UM. Here, we aimed to determine biological significance lncRNA growth arrest-specific transcript 5 (GAS5) in UM.The expression levels GAS5 and microRNA-21 (miR-21) UM tissues cells were detected by qRT-PCR analysis. CCK-8 assay was performed investigate viability after cell transfections, migration invasion...
Nischarin regulates Rac1-dependent cell motility by interaction with and inhibition of the p21-activated kinase (PAK1). In addition to regulating activation PAK1, Rac1 controls multiple downstream pathways regulate growth differentiation, as well motility. Signaling a constitutively activated mutant deficient in PAK binding (Rac1Q61L-40C) was examined determine whether impinges on these other effector pathways. formed immunoprecipitatable complexes Rac1Q61L Rac1Q61L-40C when proteins were...
N staging systems are paramount clinical features for colorectal cancer (CRC). In N1 stage (N1) CRC, patients present with a limited number of metastatic lymph nodes, yet their prognoses vary widely. The tumor invasion proportion nodes (TIPLN) has gained attention, but its prognostic value in CRC remains unclear. We retrospectively analyzed 416 who underwent radical surgery from January 2014 to December 2018, reviewing 713 hematoxylin and eosin (H&E)-stained slides assess TIPLN. Overall...