A5115695323- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Shoulder and Clavicle Injuries
- Virology and Viral Diseases
- Viral Infections and Vectors
- Trauma Management and Diagnosis
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Neurological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Clostridium difficile and Clostridium perfringens research
- Plant nutrient uptake and metabolism
- Plant Reproductive Biology
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Virus-based gene therapy research
- Liver Diseases and Immunity
Wuhan University
2025
Chinese Academy of Sciences
2024
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
University of Shanghai for Science and Technology
2024
Sun Yat-sen University
2024
Heilongjiang Provincial Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2022-2024
Numerous studies emphasize the pivotal role of inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD) development. Some link specific systemic immune biomarkers (e.g., immuno-inflammatory index [SII], neutrophil-to-albumin ratio [NPAR] and neutrophil-to-lymphocyte [NLR]) to hepatic steatosis risk. However, relevance other markers like immune-inflammation [SIRI], platelet-to-lymphocyte [PLR] lymphocyte/monocyte [LMR] MASLD remains unclear. Limited literature covers...
Prehospital delay (time from symptom onset of stroke to the door a hospital) in patients with is long China. With goal improving public awareness and knowledge recognition, Stroke 1-2-0 was developed China as an education program prompt rapid response based on clinical practice China, examination its outcomes needed.To investigate association educational campaign prehospital for ischemic stroke.In population-based cross-sectional study, all events were admitted Minhang Hospital, which only...
Introduction A crucial aspect of stroke progression is the inflammatory response. As novel and prognostic markers, systemic immune inflammation index (SII) response (SIRI) have recently been studied. The objective our study was to evaluate value SII SIRI in mild acute ischemic (AIS) patients following intravenous thrombolysis (IVT). Methods Our screened clinical data with AIS admitted Minhang Hospital Fudan University for retrospective analysis. were examined by emergency laboratory before...
Nipah virus (NiV) is a zoonotic emergent paramyxovirus that can cause severe encephalitis and respiratory infections in humans, with high fatality rate ranging from 40% to 75%. Currently, there are no approved human vaccines or antiviral drugs against NiV. Here, we designed ferritin-based self-assembling nanoparticle displaying the NiV G head domain on surface (NiV G-ferritin) assessed immune responses elicited by soluble sG) G-ferritin. Immunization G-ferritin sG conferred complete...
Abstract This study investigates the relationship between corporate environmental performance, as captured by investment, and firms’ access to trade credit. Using data from Chinese listed firms in heavy pollution industries, we find that performance significantly increases The positive effect of investment appears more pronounced for with stronger internal incentives conduct eco‐friendly practices, lower external regulatory pressure located regions higher economic growth rates. Two factors –...
TPX2 is an elongated molecule containing multiple α-helical repeats. It stabilizes microtubules (MTs), promotes MT nucleation, and essential for spindle assembly. However, the molecular basis of how performs these functions remains elusive. Here, we systematically characterized MT-binding activities all modules individually in combinations investigated their respective contributions both vitro cells. We show that contains repeats with opposite preferences “extended” “compacted” tubulin dimer...
Nipah virus (NiV) and Hendra (HeV), two highly pathogenic Henipaviruses (HNVs), pose a significant public health threat. The attachment glycoprotein (G) plays crucial role in viral entry, making it an attractive target for vaccine therapeutic antibody development. However, the antigenic landscape neutralization sensitivity of G protein remain poorly defined. Here, we systematically characterize 27 monoclonal antibodies (mAbs) elicited by NiV head (GH) nanoparticle-immunized mice. Among...
Lettuce (Lactuca sativa L.) is an annual plant of the Asteraceae family, commonly used as a fresh-cut vegetable and primary ingredient in salads. It rich vitamins, minerals, polyphenols, carotenoids, providing numerous health benefits. In 2021, lettuce achieved gross production value $16.6 billion worldwide, with China, United States, Western Europe leading producers (Food Agriculture, 2023Food AgricultureOrganization Nations. FAOSTAT, Rome2023Google Scholar). Most cultivated varieties are...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe viral hemorrhagic and a fatality rate of up to 30%. No licensed vaccines or therapeutics are currently available for humans. Here, we develop seven monoclonal antibodies (mAbs) against SFTSV surface glycoprotein Gn. Mechanistic studies show three neutralizing mAbs (S2A5, S1G3, S1H7) block multiple steps during infection, including attachment membrane fusion, whereas another mAb (B1G11)...
Background: Mycoplasma pneumoniae is a significant cause of respiratory infections in children, often leading to severe pneumonia. This study aimed assess the clinical relevance interferon-gamma (interferon-γ), D-dimer, lactate dehydrogenase (LDH), and C-reactive protein (CRP) as biomarkers severity mycoplasma pneumonia pediatric patients. Methods: In this prospective study, 203 patients with were classified into mild (123 patients) (80 groups. Biomarkers including interferon-γ, LDH, CRP...
Abstract Objectives A good mastery of stroke‐related knowledge can be great benefit in developing healthy behaviours. This study surveyed the about stroke and influencing factors among patients with acute ischaemic (AIS) at discharge a Chinese province. Methods cross‐section was conducted from November 1, 2014 to January 31, 2015. total 1531 AIS Hubei Province completed questionnaire discharge. Multivariate linear regression used identify their stroke. Results About 31.2% respondents did not...
Activation of emergency medical services (EMS) is recommended for timely reperfusion therapy acute ischemic stroke (AIS). The association EMS utilization and time intervals from hospital arrival to a series necessary procedures before was rarely investigated.The objective this study investigate the with in patients AIS.Observational study.Medical records AIS all departments Beijing were obtained January 2018 December 2021.Patients transported by ambulance defined as group, whereas others...
Comprehensive research on the impact of various types refractive errors (RE) and anisometropia dry eye disease is still lacking. This study aimed to estimate prevalence rates potential lifestyle factors related symptomatic (SDE) among adolescents in eastern China.
Summary Bolting time is an important agronomic trait in lettuce ( Lactuca sativa ) production. Premature bolting significantly reduces crop quality and marketability. Here, we report map‐based cloning characterization of a LsKN1 gene that controls lettuce. A segregating population was developed by crossing crisphead‐type cultivar with stem‐type to genetically map clone the gene. In late‐bolting parent (crisphead), activated CACTA‐like transposon which inserted into first exon ....
As two of the most impactful abiotic stresses, salt and drought strongly affect tomato growth development, especially at seedling stage. However, dissection genetic basis underlying salt/drought tolerance stage in remains limited scope. Here, we reported an analysis major quantitative trait locus (QTL) potential causal variations recombinant inbred lines (n = 201) S. pimpinellifolium lycopersicum parents by whole genome resequencing. A total 5 QTLs on chromosome 1, 3, 5, 7 12 for (ST) 15 4,...
The rapid increase in fertilizer use has led to the degradation of soil quality, nutrient imbalances, reduced biodiversity, and compaction. To address these challenges, hybrid soybeans with efficient biological nitrogen fixation capabilities broad environmental adaptability were selected as green manure reduce application, thereby improving fertility structure. This study utilized varieties “Forage Soybean S001” (S001), “Neinong S002 Forage Soybean” (S002), “Mengnong S003 (S003), S004...
Postoperative cognitive dysfunction (POCD) is a common challenge faced by older adults. One of the key contributors to development POCD neuroinflammation induced microglia. Resveratrol has emerged as promising candidate for prevention decline. Previous studies have demonstrated its potential in alleviating deterioration, yielding encouraging results. Nonetheless, mechanism resveratrol improving function remains unclear. Therefore, we assessed effect both aged model mice and BV2 cells on...