A5035387054- vaccines and immunoinformatics approaches
- Virology and Viral Diseases
- Liver Diseases and Immunity
- Dermatological diseases and infestations
- Hepatitis B Virus Studies
- Beetle Biology and Toxicology Studies
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Insects and Parasite Interactions
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Viral Infections and Vectors
- Liver physiology and pathology
Wuhan University
2024
University of Alberta
2011
Nipah virus (NiV) is a zoonotic emergent paramyxovirus that can cause severe encephalitis and respiratory infections in humans, with high fatality rate ranging from 40% to 75%. Currently, there are no approved human vaccines or antiviral drugs against NiV. Here, we designed ferritin-based self-assembling nanoparticle displaying the NiV G head domain on surface (NiV G-ferritin) assessed immune responses elicited by soluble sG) G-ferritin. Immunization G-ferritin sG conferred complete...
Nipah virus (NiV) and Hendra (HeV), two highly pathogenic Henipaviruses (HNVs), pose a significant public health threat. The attachment glycoprotein (G) plays crucial role in viral entry, making it an attractive target for vaccine therapeutic antibody development. However, the antigenic landscape neutralization sensitivity of G protein remain poorly defined. Here, we systematically characterize 27 monoclonal antibodies (mAbs) elicited by NiV head (GH) nanoparticle-immunized mice. Among...