A5101698251- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Malaria Research and Control
- COVID-19 diagnosis using AI
- Reproductive tract infections research
- COVID-19 epidemiological studies
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Viral Infections and Immunology Research
- Travel-related health issues
- Data-Driven Disease Surveillance
- Zoonotic diseases and public health
- Global Maternal and Child Health
Wuhan University
2020-2024
State Key Laboratory of Virology
2023-2024
Wuhan Institute of Virology
2021-2024
Nanjing Drum Tower Hospital
2022
Nanjing University
2022
Wuhan University of Science and Technology
2020
Currently, the outbreak of COVID-19 is rapidly spreading especially in Wuhan city, and threatens 14 million people central China. In present study we applied Moran index, a strong statistical tool, to spatial panel show that infection spatially dependent mainly spread from Hubei Province Central China neighbouring areas. Logistic model was employed according trend available data, which shows difference between outside it. We also calculated reproduction number R0 for range [2.23, 2.51] via...
Zika virus (ZIKV) is a unique flavivirus with high tropism to the testes. ZIKV can persist in human semen for months and cause testicular damage male mice. However, mechanisms through which enters testes remain unclear. In this study, we revealed that matrix metalloproteinase 9 (MMP9) was upregulated by infection cell culture A129 Furthermore, using an vitro Sertoli barrier model MMP9-/- mice, found directly affected permeability of blood-testis (BTB), knockout or inhibition MMP9 reduced...
Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, role of ER autophagy (ER-phagy) viral process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection results from degradation ER-phagy receptor FAM134B, facilitated by NS2A protein. Mechanistically, ER-localized undergoes K48-linked polyubiquitination at lysine (K) 56 E3 ligase AMFR. Ubiquitinated binds to FAM134B and AMFR orchestrates NS2A-FAM134B complexes....
In recent years, various serious diseases caused by Zika virus (ZIKV) have made it impossible to be ignored. Confirmed existence of ZIKV in semen and sexually transmission suggested that can break the blood-testis barrier (BTB), or Sertoli cell (SCB). However, little is known about underlying mechanism. this study, interaction between actin, an important component SCB, envelope (E) protein domain III (EDIII) was inferred from co-immunoprecipitation (Co-IP) liquid chromatography-tandem mass...
Abstract Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2 strain, based on which vaccines developed. Here, we develop six human monoclonal antibodies (mAbs) from two elite convalescents in Wuhan and show that these mAbs recognize diverse epitopes receptor binding domain (RBD) can inhibit infection strain variants concern (VOCs) to varying degrees, including Omicron strains XBB XBB.1.5. Of mAbs, most...
The coronavirus disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has become the worst public health crisis in a century. However, knowledge about dynamics of antibody responses patients with COVID-19 is still poorly understood. In this study, we performed serological study serum specimens collected at and convalescent phases from 104 who were part first wave cases Wuhan, China. Our findings revealed that neutralizing antibodies to SARS-CoV-2 are...
Abstract Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious and has spread worldwide. Clinical risk factors associated with the severity in COVID-19 patients have not yet been well delineated. The aim of this study was to explore related progression severe establish a prediction model for patients. Methods: We retrospectively recruited confirmed admitted Enze Hospital, Taizhou Medical Center (Group) Nanjing Drum Tower Hospital between January 24 March 12, 2020. Take...