A5100348919- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- COVID-19 epidemiological studies
- Cancer Treatment and Pharmacology
- COVID-19 and healthcare impacts
- Breast Cancer Treatment Studies
- Hormonal Regulation and Hypertension
- Advanced Breast Cancer Therapies
- Renal and related cancers
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Ultrasound Imaging and Elastography
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- HER2/EGFR in Cancer Research
- Ultrasound and Hyperthermia Applications
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Chemical Synthesis and Analysis
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Lymphatic System and Diseases
Brigham and Women's Hospital
2020-2025
Harvard University
2020-2025
Tianjin Medical University Cancer Institute and Hospital
2017-2025
Nanjing Drum Tower Hospital
2023-2025
Peking University
2013-2024
Peking University People's Hospital
2013-2024
University of Macau
2023
Affiliated Hospital of Guizhou Medical University
2023
Guiyang Medical University
2023
Chinese People's Liberation Army
2023
Abstract The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally vulnerable to infections, systematic analysis diverse cohorts by is needed. We performed a multicenter study including 105 536 age-matched noncancer confirmed COVID-19. Our results showed had higher risks in all severe outcomes. Patients hematologic cancer, lung or metastatic (stage IV) the highest frequency events. nonmetastatic...
Currently, the outbreak of COVID-19 is rapidly spreading especially in Wuhan city, and threatens 14 million people central China. In present study we applied Moran index, a strong statistical tool, to spatial panel show that infection spatially dependent mainly spread from Hubei Province Central China neighbouring areas. Logistic model was employed according trend available data, which shows difference between outside it. We also calculated reproduction number R0 for range [2.23, 2.51] via...
Rapid proliferation and Warburg effect make cancer cells consume plenty of glucose, which induces a low glucose micro-environment within the tumor. Up to date, how keep proliferating in condition insufficiency still remains be explored. Recent studies have revealed close correlation between excessive fructose consumption breast genesis progression, but there is no convincing evidence showing that could directly promote development. Herein, we found fructose, not amino acids, functionally...
Introduction Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to significant decrease PD-L1 expression tumors. However, this is not sustained and efficient process. Therefore, we designed cyclic achieve anti-PD-L1 effect. Methods We synthesized an improvement targeting DHHC3, used disulfide bonds stabilize the continuous N- C-termini peptides maintain their structure. Cellular molecular biology techniques were test...
Abstract Peptide-drug conjugates (PDCs) have emerged as a promising strategy in cancer therapy, offering improved therapeutic efficacy and reduced toxicity. Compared to antibody-drug (ADCs) small molecule-drug (SMDCs), PDCs possess distinct advantages, such lower immunogenicity, tumor penetration, simpler synthesis. This review discusses the latest advancements PDC design, including novel peptide targeting mechanisms, linker selection, formulation improvements for increased stability....
ABSTRACT Glutaminase‐1 (GLS1) has garnered considerable interest as a metabolic target in cancer due to its heightened involvement and activity. However, the precise fate of glutaminolysis catalysed by GLS1 cells remains elusive. We found that knockout led significant suppression cell proliferation, which can be reversed or partially restored supplementation glutamate non‐essential amino acids converted into glutamate. The addition spliceosomal KGA GAC ameliorates growth vitro vivo,...
Abstract Immunomodulatory imide drugs (IMiDs) degrade specific C2H2 zinc finger degrons in transcription factors, making them effective against certain cancers. SALL4, a cancer driver, contains seven fingers three clusters, including an IMiD degron cluster one (ZFC1). Surprisingly, IMiDs do not inhibit the growth of SALL4-expressing cells. To overcome this limit, we focused on non-IMiD domain, SALL4 four (ZFC4). By combining ZFC4-DNA crystal structure and silico docking algorithm,...
Patients with lung cancer are presumed to be at high risk from COVID-19 infection due underlying malignancy. A total of 31 patients pre-diagnosed and 186 age sex matched without in 6 hospitals Wuhan, China were identified our study. There was a significantly higher level IL-6 group showed by multifactorial analysis. The restricted mean survival time 10, 20, 53 days ealier than non-cancer the same observation (all P values < 0.05). Our results indicated that associated morbidity mortality patients.
Estrogens play important roles in autoimmune thyroiditis, but it remains unknown which estrogen receptor (ER) subtype mediates the stimulatory effects. Herein we treated ovariectomized mice with ERα or ERβ selective agonist followed by thyroglobulin-immunization to induce experimental thyroiditis (EAT), and observed aggravation of EAT after diarylpropionitrile (DPN, agonist) administration. The mRNA levels interleukin(IL)-17A, IL-21 RORγt percentages T helper (Th) 17 cells were up-regulated...
Abstract Oncofetal protein SALL4 is critical for cancer cell survival. Targeting SALL4, however, only applicable in a fraction of patients who are positive this gene. To overcome limitation, we propose to induce vulnerability by engineering partial dependency upon SALL4. Following exogenous expression SALL4-negative cells became partially dependent on Treatment with the FDA-approved hypomethylating agent 5-aza-2′-deoxycytidine (DAC) resulted transient upregulation DAC pretreatment sensitized...
Comorbidities such as hypertension could exacerbate symptoms of coronaviral disease 2019 (COVID)-19 infection. Patients with may receive both anti-COVID-19 and antihypertension therapies when infected COVID-19. However, it is not clear how different classes anti-hypertension drugs impact the outcome COVID-19 treatment. Herein, we explore association between inpatient use mortality among patients hospitalized We totally collected data from 278 diagnosed admitted to hospitals in Wuhan February...
Background: Indocyanine green (ICG) lymphography is a newer technique for diagnosing lymphedema. Our study aimed to find whether the abnormality of ICG can predict occurrence early lymphedema and then select candidates at high risk developing Methods: Postoperative breast cancer patients who visited clinic Peking University People’s Hospital from December 2016 September 2019 were consecutively enrolled received circumference measurement. Data collected on patients’ characteristics...
Background: Bioelectrical impedance technology is a common technique used for the early detection of breast cancer-related lymphedema (BCRL).However, studies on threshold value established by Inbody 720 device (Biospace, Korea) have been extremely limited.We aimed to determine its reference range and cutoff values.Methods: All patients were recruited from October 2017 2019 at Peking University People's Hospital Breast Center.In total, 82 with unilateral BCRL 1305 healthy subjects in this...
Abstract Background Previous studies have suggested that reproductive factors are associated with breast cancer risk. Breast subtypes distinct natural characteristics and may also unique risk profiles. The purpose of this study was to determine whether affect the by estrogen receptor (ER)/progesterone (PR) HER2 status. Methods A multicenter, case-control conducted. There were 1170 patients age- hospital-matched females included in analysis. Self-reported data collected about lifestyle...
Immunomodulatory imide drugs (IMiDs) degrade specific C2H2 zinc finger degrons in transcription factors, making them effective against certain cancers. SALL4, a cancer driver, contains seven fingers four clusters, including an IMiD degron cluster two (ZFC2). Surprisingly, IMiDs do not inhibit growth of SALL4 expressing cells. To overcome this limit, we focused on non-IMiD degron, (ZFC4). By combining AlphaFold and the ZFC4-DNA crystal structure, identified potential ZFC4 drug pocket....