A5101867998- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Health and Risk Factors
- Phonocardiography and Auscultation Techniques
- SARS-CoV-2 detection and testing
- Cardiac tumors and thrombi
- Peptidase Inhibition and Analysis
- Coastal and Marine Management
- Ginseng Biological Effects and Applications
- Cytomegalovirus and herpesvirus research
- Prion Diseases and Protein Misfolding
- interferon and immune responses
- Amoebic Infections and Treatments
- COVID-19 Impact on Reproduction
- MRI in cancer diagnosis
- Ultrasound in Clinical Applications
- Immune Cell Function and Interaction
- Thyroid Cancer Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Gallbladder and Bile Duct Disorders
Zhongnan Hospital of Wuhan University
2015-2025
Wuhan University
2015-2025
Shandong First Medical University
2025
Shandong Tumor Hospital
2025
Huazhong University of Science and Technology
2020
Renmin Hospital of Wuhan University
2020
Hubei Cancer Hospital
2020
Union Hospital
2020
Central Hospital of Wuhan
2020
Guangzhou Medical University
2020
Abstract The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally vulnerable to infections, systematic analysis diverse cohorts by is needed. We performed a multicenter study including 105 536 age-matched noncancer confirmed COVID-19. Our results showed had higher risks in all severe outcomes. Patients hematologic cancer, lung or metastatic (stage IV) the highest frequency events. nonmetastatic...
Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression prognosis of patients with COVID-19. Methods: We retrospectively reviewed information 1,751 COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate multivariate Cox regression analyses as well Logistics analyses, Kaplan-Meier curves were used to determine association LDH levels patients. Results: was an independent risk factor for in-hospital death no...
Breast cancer is a fatal malignancy facing human health, with most patients experiencing recurrence and resistance to chemotherapy. The immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. This study aimed develop modality theranostics nanoparticles for breast based on near-infrared light-triggered nanoparticle targeted delivery ginsenoside Rg3 immune adjuvants imiquimod (R837) effective Folate-receptor (FA) targeting IR780-R837/ginsenoside...
Artemisinin, originally used for its antimalarial activity, has received much attention in recent years cancer therapy. The anticancer mechanisms of artemisinin are complicated and debatable. Challenges the delivery also persist because effect alone is often not satisfactory when with traditional nanocarriers. We herein report mitochondrial extremely high capacity. action mode mitochondria cells includes heme-participating oxygen-independent conversion into a carbon-centered radical, which...
Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: A total 245 adult patients laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher's exact, and Mann-Whitney U-tests used to compare clinical characteristics between survivors non-survivors. To explore in-hospital death, univariable multivariable cox regression...
Viral mutations and immune dysfunction still lead to recurrent infections of COVID-19 in cancer patients. Our aim this study was explore the differences cumulative risk death from different types characterise clinical demographic factors associated with death. We conducted a population-based using National Cancer Database, which included all types. calculated age-standardised mortality, mortality. Further, we employed multivariate competing analysis calculate 5.3% patients suffered The...
Polypoid endometriosis (PEM) is a rare and distinctive variant of endometriosis, with ectopic endometrium presenting as polypoid appearance. Due to the irregular shape mass on imaging, accompanied by obvious blood flow signals often elevated tumor marker CA125, it prone be misdiagnosed malignant tumor. We report 43-year-old female history ovarian in whom heterogeneous echo was found pelvic cavity. The mass, located peritoneum adhered omentum majus, had an prominent signals, complicating...
Patients with lung cancer are presumed to be at high risk from COVID-19 infection due underlying malignancy. A total of 31 patients pre-diagnosed and 186 age sex matched without in 6 hospitals Wuhan, China were identified our study. There was a significantly higher level IL-6 group showed by multifactorial analysis. The restricted mean survival time 10, 20, 53 days ealier than non-cancer the same observation (all P values < 0.05). Our results indicated that associated morbidity mortality patients.
To investigate the accuracy of ultrasonic diagnosis using tele-ultrasound robot in Leishen Shan Hospital.Twenty-two patients with novel coronavirus pneumonia from Hospital voluntarily participated this study. Their thyroids, neck vessels, hepatobiliaries and kidneys were scanned by both a manufactured Imabot Co., Ltd, Wuhan conventional method. The ultrasound each patient was compared, images obtained two methods mixed together double-blindly diagnosed an experienced radiologist.There 44...
An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 infection occurred in Wuhan, China, December 2019. To date, the analysis fatal cases and risk factors for death have rarely been reported.In this study, 220 adult patients with confirmed suspected COVID-19 were enrolled. Clinical characteristics, laboratory data, treatments, complications compared between 168 survivors 52 nonsurvivors. Univariable multivariable logistic regression used to...
Abstract Background Two types of non-invasive, radiation-free, and inexpensive imaging technologies that are widely employed in medical applications ultrasound (US) infrared thermography (IRT). The image obtained by primarily expresses the size, shape, contour boundary, echo, other morphological information lesion, while thermal describes its thermodynamic function information. Although distinguishing between benign malignant thyroid nodules requires both functional information, present deep...
Pharmacologically targeting the STING pathway offers a novel approach to cancer immunotherapy. However, small-molecule agonists face challenges such as poor tumor accumulation, rapid clearance, and short-lived effects within microenvironment, thus limiting their therapeutic potential. To address of specificity inadequate in breast treatment, herein, we report design development targeted liposomal delivery system modified with tumor-targeting peptide iRGD (iRGD-STING-PFP@liposomes). With LIFU...
Background Coronavirus disease 2019 (COVID-19) has evolved into a pandemic. We hypothesized that biochemical indicators of liver function may help determine the prognosis COVID-19 patients. Methods Patient information was collected from Wuhan-Leishenshan hospital. Logistic and Cox regression analyses, Kaplan-Meier curves, Curve fitting were used to correlation between elevated levels aspartate transaminase (AST), alanine (ALT), AST/ALT severity disease/mortality. Results analyses survival...
Liposarcoma is a malignant tumor of adipocytic differentiation that rarely arises within the mediastinum. Most existing data available comes from scattered case reports and few small series. A 51-year-old man was admitted with cough sputum accompanied by fever. X-ray CT showed bulky anterior mediastinal mass initially misdiagnosed as teratoma. PET/CT demonstrated lesion on location showing area moderately intense uptake. After surgical excision, histopathological examination via hematoxylin...
Abstract The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally vulnerable to infections, systematic analysis diverse cohorts by needed. We performed a multi-center study including 105 536 age-matched non-cancer confirmed COVID-19. Our results showed had higher risks in all severe outcomes. Patients hematological cancer, lung or metastatic (stage IV) the highest frequency events. Non-metastatic...
The present case report details a unique of 51-year-old male patient who underwent radical operation for carcinoma the stomach and pancreaticoduodenectomy. Conventional ultrasonography examination exhibited characteristic ̔bull's eye̓ sign in liver; whereas real‑time contrast‑enhanced (CEUS) demonstrated was suffering from hepatic abscess, corroborated by cytologic examination, which confirmed presence Acinetobacter baumannii. localization A. baumannii is rare tumor patients presenting with...
Background: Modernization of Chinese adults is associated with increased atherosclerotic diseases. Over 1 million farmers have been resettled upland since 1996 in the Three Gorges dam project Yangtze River, job and other lifestyle changes. We aimed to evaluate impact such rapid changes on indices cardiometabolic health. Methods: Ninety-five ex-farmers Wu Shan (WS) (aged 49.7 ± 9 years) uphill for 3–5 years 87 age gender-matched Da Chang (DC) 48.8 10 studied before resettlement were compared....
Breast cancer has become one of the most common cancers in world, and it is also lethal women. As a non-invasive imaging modality, ultrasonography can diagnose degree breast lesions be used for large-scale screening. However, since ultrasound(BUS) images are morphologically diverse, accompanied by relatively low contrast complex textures, BUS image recognition faces greater challenges than natural images. In this study, We propose novel network architecture that combines convolutional neural...
This paper aims to discuss the evaluation of therapeutic effect contrast-enhanced ultrasonography (CEUS) in radiofrequency ablation (RFA) for liver cancer and its application value. A total 80 patients (120 hepatic malignant tumor lesions) were treated using RFA, CEUS was conducted on before after treatment. Sixty-five (85/120 had primary carcinoma 11 (30/120 metastatic (6 cases 15 lesions colorectal carcinoma, 3 8 lung 2 7 gastric carcinoma). Four (5 recurrence. Prior treatment, accurately...
Wilson disease is an autosomal recessive genetic found by Samuel Alexander Kinnier and prevalent in childhood adolescents.
Automated severity assessment of coronavirus disease 2019 (COVID-19) patients can help rationally allocate medical resources and improve patients' survival rates. The existing methods conduct tasks mainly on a unitary modal single view, which is appropriate to exclude potential interactive information. To tackle the problem, in this paper, we propose multi-view multi-modal model automatically assess COVID-19 based deep learning. proposed receives ultrasound images biomedical indices...