A5100716660- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Viral Infections and Vectors
- Neuroblastoma Research and Treatments
- Invertebrate Immune Response Mechanisms
- Birth, Development, and Health
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Outbreaks Research
- Neurobiology and Insect Physiology Research
- SARS-CoV-2 and COVID-19 Research
- Physiological and biochemical adaptations
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Pancreatic function and diabetes
- Biochemical and Structural Characterization
- Ultrasound and Hyperthermia Applications
- Lipid metabolism and disorders
- Cerebral Palsy and Movement Disorders
- Vibrio bacteria research studies
- Parvovirus B19 Infection Studies
- Growth Hormone and Insulin-like Growth Factors
- Marine Sponges and Natural Products
- Vitamin D Research Studies
- Hydrological Forecasting Using AI
- Metaheuristic Optimization Algorithms Research
Capital Medical University
2014-2025
Beijing Children’s Hospital
2014-2025
Wuhan University
2021-2024
Shandong University
2013-2023
Northwest Institute of Mechanical and Electrical Engineering
2023
North China Electric Power University
2022
Shandong First Medical University
2022
Tianjin Medical University Cancer Institute and Hospital
2020
Aviation Industry Corporation of China (China)
2019
First Affiliated Hospital of GuangXi Medical University
2018
The genomes of myxobacteria harbor a variety biosynthetic gene clusters encoding numerous secondary metabolites, including ribosomally synthesized and post-translationally modified peptides (RiPPs) with diverse chemical structures biological activities. However, the potential RiPPs from remains barely explored. Herein, we report novel lanthipeptide myxococin identified Myxococcus fulvus. Myxococins represent first example lanthipeptides, which characteristic multiple thioether rings are...
Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, role of ER autophagy (ER-phagy) viral process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection results from degradation ER-phagy receptor FAM134B, facilitated by NS2A protein. Mechanistically, ER-localized undergoes K48-linked polyubiquitination at lysine (K) 56 E3 ligase AMFR. Ubiquitinated binds to FAM134B and AMFR orchestrates NS2A-FAM134B complexes....
Serum iron biomarkers are disordered on the progression of obesity and its associated metabolic syndrome (MetS). However, limited evidence is explored interactions between serum incidence MetS. Thus, purpose this study to discuss whether epigenetic modifications nuclear mitochondrial DNA (mtDNA) with disturbance among metabolically unhealthy (MUO) school-age children. A representative cross-sectional was performed using data from 104 children, while subjects without were as controls (n =...
The COVID-19 pandemic caused by SARS-CoV-2 infection has placed health systems under excessive pressure and especially elderly people with cancer. Glioblastoma multiforme (GBM) is a malignant brain tumor an increasing incidence in individuals, thereby GBM patients are vulnerable population during the outbreak. Accumulating studies have implied that might invade directly via coronavirus receptors. However, little known about clinical development of GBM. Here, we explored oncogenic roles six...
Numerical Weather Prediction (NWP) is a necessary input for short-term wind power forecasting. Existing NWP models are all based on purely physical models. This requires mainframe computers to perform large-scale numerical calculations and the technical threshold of assimilation process high. There need further improve timeliness accuracy process. In order solve above problems, method artificial intelligence proposed in this paper. It uses convolutional neural network algorithm downscaling...
Abstract In June 2013, a subclinical infection with severe fever thrombocytopenia syndrome virus (SFTSV) was detected in Zhejiang Province, China, prompting seroprevalence studies 6 districts within the province. Of 986 healthy persons tested, 71 had IgG antibodies against SFTSV. This finding suggests that most natural infections SFTSV are mild or subclinical.
West Nile virus (WNV) causes potentially fatal neuroinvasive disease and persists at endemic levels in many parts of the world. Despite advances our understanding WNV pathogenesis, there remains a significant need for human vaccine. The domain III (DIII) region envelope protein contains epitopes that are target neutralizing antibodies. We have constructed chimeric fusion non-toxic cholera toxin (CT) CTA2/B domains to DIII investigation as novel mucosally-delivered Purification assembly...
Along with the control and prevention of coronavirus disease 2019 transmission, infected animals might have potential to carry virus spark new outbreaks. However, very few studies explore susceptibility severe acute respiratory syndrome 2 (SARS-CoV-2). Viral attachment as a crucial step for cross-species infection requires angiotensin-converting enzyme (ACE2) receptor depends on TMPRSS2 protease activity. Here, we searched genomes metazoans from different classes using an extensive BLASTP...
The final stage of Ebola virus (EBOV) replication is budding from host cells, where the matrix protein VP40 essential for driving this process. Many post-translational modifications such as ubiquitination are involved in egress, but acetylation has not been studied yet. Here, we characterize NEDD4 acetylated at a conserved Lys667 mediated by acetyltransferase P300 which drives egress Importantly, P300-mediated promotes NEDD4-VP40 interaction enhances E3 ligase activity and activation...
We conducted a cohort study to elucidate the molecular spectrum of congenital hyperinsulinism (CHI) in Chinese pediatric patients. Thirty children with CHI were chosen as research subjects, 16 whom responsive diazoxide and 13 not (1 patient was given drug for medical reasons). All exons adenosine triphosphate (ATP)-sensitive potassium channel (KATP channel) genes KCNJ11 ABCC8, hepatocyte nuclear factor 4 α (HNF4A) gene, Glucokinase (GCK) gene well 6 7 10-12 glutamate dehydrogenase 1 (GLUD1)...
In an effort to determine the cause of non-A-E hepatitis, a retrospective study was undertaken on group patients with hepatitis but without serological infection markers viruses A-E. A total 60 admitted Beijing Ditan Hospital during period September 1997 and 1999 were chosen for this study. These diagnosed as either acute or chronic no A-E detected. Since TT virus (TTV), human parvovirus B19 (B19), SEN (SENV), GB C/HGV reported be associated attempts made detect presence these in sera by...
AIM:To detect infection rate of GBV-C/HGV in hepatitis C patients, to determine the methods higher sensitivity and primers efficiency for RNA detection study dominant subtype mutation GBV-C/HGV.METHODS:Quantitative RT-PCR pf HCV concentration serum samples, RT-nested PCR with two sets GBV-C RNA, ELISA HGV nucleotide sequence putative amino acid analysis.RESULTS:The positive rates at 5'-NCR NS3 region 211 serums amples from patients were 31.8% 22.8% respectively. The NS5 same samples 47.9%...
Background Severe hypertriglyceridemia usually results from a combination of genetic and environmental factors is most often attributable to mutations in the lipoprotein lipase ( LPL ) gene. Objectives The aim this study was identify rare gene causing severe hypertriglyceridemia. Methods A Chinese infant who presented classical features recruited for DNA sequencing pathogenicity grade variants defined based on prediction using silico tools. Review some studies understand molecular mechanisms...
This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 August 2017, their families, selected as subjects. The CHI-related causative genes sequenced analyzed using second-generation sequencing technology. Furthermore, pathogenesis characteristics CHI explored. Among...
Microwave photonic sensors are promising for improving sensing resolution and speed of optical sensors. In this paper, a high-sensitivity, high-resolution temperature sensor based on microwave filter (MPF) is proposed demonstrated. A micro-ring resonator (MRR) silicon-on-insulator used as the probe to convert wavelength shift caused by change frequency variation via MPF system. By analyzing with high-speed monitors, can be detected. The MRR designed multi-mode ridge waveguides reduce...
To investigate the nutritional status of children with Crohn's Disease (CD) at diagnosis and its association clinical characteristics.
Abstract In this paper, the engineering of pulse power supply in electromagnetic launch technology is studied depth, advantages and disadvantages optical fiber communication transmission currently used are analyzed, then requirements for data system summarized, several commonly wireless technologies analyzed compared, such as ZigBee, LoRa, SigFox, NB IoT, 5G, etc. According to comprehensive comparison these distance, rate, bandwidth, security, time delay, self built network other aspects,...