A5100784038- Gut microbiota and health
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Diagnosis and treatment of tuberculosis
- Genetic Mapping and Diversity in Plants and Animals
- Alcohol Consumption and Health Effects
- Cancer therapeutics and mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Synthesis and biological activity
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- Clostridium difficile and Clostridium perfringens research
- Genetic Neurodegenerative Diseases
- Actinomycetales infections and treatment
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Osteoarthritis Treatment and Mechanisms
Soochow University
2012-2024
First Affiliated Hospital of Soochow University
2012-2024
Tianjin Medical University General Hospital
2024
Yixing People's Hospital
2012-2023
Jiangsu University
2012-2023
China National Pharmaceutical Group Corporation (China)
2023
Hubei University of Medicine
2023
Dongfeng General Hospital
2023
Dalian Medical University
2019-2021
Second Affiliated Hospital of Dalian Medical University
2019-2021
Prospective cohort studies are needed to assess the relationship between fecal microbiome and human health disease. To evaluate collection methods, we determined technical reproducibility, stability at ambient temperature, accuracy of 5 methods (no additive, 95% ethanol, RNAlater Stabilization Solution, occult blood test cards, immunochemical tubes). Fifty-two healthy volunteers provided samples Mayo Clinic in Rochester, Minnesota, 2014. One set from each sample method was frozen...
Several studies based on 16SrDNA analysis have revealed certain unique characteristics of gut microbiome in centenarians. We established a prospective cohort fecal microbiota and conducted the first metagenomics-based study among The objective was to explore dynamic changes healthy centenarians approaching end life unravel aging-associated microbiome. Seventy-five residing three regions Hainan participated follow-up surveys collection samples at intervals 3 months. Data pertaining dietary...
Background: Lung cancer has the highest incidence and mortality rate of any worldwide. Platinum-based combination chemotherapy is still standard treatment for advanced lung cancer. However, clinical efficacy this can be affected by its adverse reactions, especially gastrointestinal mucositis. The reactions often lead to delayed reduced medication. role played gut microbiome in becoming clearer, evidence suggests that regulation may affect response multiple types treatment. Methods: Sixty...
Dysregulation of miRNAs in chondrocytes has been confirmed to participate osteoarthritis (OA) progression. Previous study screen out several key may play crucial role OA based on bioinformatic analysis. Herein, we identified the downregulation miR-1 samples and inflamed chondrocytes. The further experiments revealed that played an essential maintaining proliferation, migration, antiapoptosis, anabolism. Connexin 43 (CX43) was predicted be target miR-1, mediated promotion effects regulating...
Abstract Background Circulating tumor DNA (ctDNA) has potential as a specific, noninvasive, and cost‐effective new biomarker for patients with lung cancer. This study aimed to determine whether plasma ctDNA can be used predict treatment outcomes in Methods Pre‐ in‐treatment blood samples were collected from 14 cancer receiving chemotherapy. Based on next‐generation sequencing technology, we constructed unique molecular identifier (UMI) library performed targeted deep of 72 genes (15 000×)....
Abstract Introduction Targeted therapies are based on specific gene alterations. Various specimen types have been used to determine alterations, however, no systemic comparisons yet made. Herein, we assessed alterations in selected cancer‐associated genes across varying sample sites lung cancer patients. Materials and Methods deep sequencing for 48 tumor‐related was applied 153 samples from 55 patients obtained six sources: Formalin‐fixed paraffin‐embedded (FFPE) tumor tissues, pleural...
ABSTRACT Lung cancer is the leading cause of death. Better understanding factors and pathways involved in lung needed to improve diagnose treatment strategies. Recent studies have provided insights into possible correlation between intestinal dysbiosis development. Although immunological relationship gut had been suggested by many researches, however, date, no study investigated characterization microbiome naïve patients, whether it distinct from that health individuals contribute onset...
<title>Abstract</title> Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) functions as an oncogene in colorectal cancer (CRC), promotes the progression of CRC, is associated with poor prognosis patients. Studies have found that NUCKS1 tumor cell metastasis, yet its role CRC invasion metastasis remains unclear. To investigate this, transwell migration assay, wound healing immunofluorescence assay were performed <italic>in vitro</italic>. Additionally, label-free...
Klebsiella pneumoniae, an opportunistic pathogen, is pervasively distributed across the world. Its escalating antibiotic resistance poses a serious threat to global public health. The mechanisms behind this remain largely elusive. In study, we performed susceptibility testing on several clinical isolates of and reference strain ATCC13883, then analysed their transcriptomic profiles identify genes pathways associated with resistance. Our results showed that isolate DY16KPN may counteract...
Dabrafenib plus trametinib (Dab + Tram) is an approved targeted therapy in patients with BRAF V600+ mutated metastatic non-small cell lung cancer (NSCLC). Here, we report the efficacy, safety, and quality of life (QoL) results Dab Tram treatment Chinese V600E mutation-positive NSCLC. This a single-arm, open-label, multicentre, phase II study (NCT04452877). Patients received dabrafenib 150 mg twice daily 2 once daily. The primary endpoint was overall response rate (ORR) by central independent...
The asymmetry in hard X-ray (HXR) emission at the footpoints (FPs) of flare loops is a ubiquitous feature closely associated with nonthermal electron transport. We analyze asymmetric HXR radiation two ribbons which thermal-dominated during long-duration C4.4 that occurred on March 20, 2023, combining multi-view and multi-waveband observations from ASO-S, SolO, SDO spacecraft. find H I Ly$\alpha$ captures similar features to He II $\lambda$304 both light curve spatio-temporal evolution pair...
FOXD2 Adjacent Opposite Strand RNA 1 (FOXD2-AS1), a long noncoding (lncRNA), exhibits specifically elevated in numerous cancerous cells. Numerous studies have shown that FOXD2-AS1 encourages cellular proliferation, migration and invasion. Nevertheless, the exact mechanism through which contributes to prostate cancer (PCa) remains unclear. Consequently, we aimed explore implications of on growth PCa. Initially, an elevation observed PCa cells (PC-3, DU145 Lncap) than normal cell line RWPE2....
Objective To evaluate the effects of femoral offset (FO) on stress level bone cement total hip arthroplasty (THA) in elder patients by three-dimensional finite element analysis. Methods The normal bilateral joints two cases was determined with CT imaging,with parameters including FO,neck shaft angle and neck length.The model THA built so as to make Von Mises analysis changes different lengths,neck angles FO. Results Stress levels prosthesis reduced monotonically increase angles.In...