A5100379005- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Media Influence and Health
- Genetic Mapping and Diversity in Plants and Animals
- Child and Adolescent Psychosocial and Emotional Development
- Child Development and Digital Technology
- Liver Disease Diagnosis and Treatment
- Impact of Technology on Adolescents
- Advanced Causal Inference Techniques
- Infant Development and Preterm Care
- Online Learning and Analytics
- Genetic Syndromes and Imprinting
- Mental Health Research Topics
- Sleep and related disorders
- Amino Acid Enzymes and Metabolism
- Early Childhood Education and Development
- Nutrition, Genetics, and Disease
- Resilience and Mental Health
- Genetic and Kidney Cyst Diseases
- Innovative Teaching and Learning Methods
- Language, Metaphor, and Cognition
- Osteoarthritis Treatment and Mechanisms
Harvard University
2024
University of Southern California
2022-2024
Hohai University
2024
Hebei University
2021-2023
Central China Normal University
2023
Shanghai University of Traditional Chinese Medicine
2023
University of Hong Kong
2021-2022
Shanghai Children's Hospital
2021
Shanghai Jiao Tong University
2021
Problematic smartphone use (PSU) in college students has been a major public health concern modern society, which may also lead to adverse outcomes. Using three-wave longitudinal study design, the current aimed examine prevalence and psychosocial factors of PSU large sample Chinese students. The data used this was obtained from an ongoing Guangdong, China. In study, total 7,434 freshmen sophomores who completed first three surveys were included. Self-administered questionnaires assess PSU,...
Objectives The causal direction and magnitude of the association between total body bone mineral density (TB-BMD) osteoarthritis (OA) risk is uncertain owing to susceptibility observational studies confounding reverse causation. study aimed explore relationships TB-BMD concentration OA using Mendelian randomization (MR). Methods In this study, we used two-sample MR obtain unconfounded estimates effect on hip knee OA. Single nucleotide polymorphisms (SNPs) strongly associated with in a large...
Abstract Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome interest. Despite wide uses various popular two‐sample MR methods based genome‐wide association study summary level data, however, those could suffer from potential power loss or/and biased inference when chosen are in linkage disequilibrium (LD), and also have relatively large direct effects whose...
Abstract Background: The circadian rhythm regulates diverse physiological and oncologic processes. We have previously shown in epidemiology studies that disruption of the may be associated with increased risk aggressive prostate cancer, including germline polymorphisms certain genes. This study sought to investigate relationship between tumor gene expression lethal cancer. Methods: studied patients primary cancer Health Professionals Follow-up Study (HPFS) Physicians’ (PHS). created a...
Abstract Recent advancement in genome‐wide association studies (GWAS) comes from not only increasingly larger sample sizes but also the shift focus towards underrepresented populations. Multipopulation GWAS increase power to detect novel risk variants and improve fine‐mapping resolution by leveraging evidence differences linkage disequilibrium (LD) diverse Here, we expand upon our previous approach for single‐population through Joint Analysis of Marginal SNP Effects (JAM) a multipopulation...
Objective Alström syndrome is an autosomal recessive genetic disease caused by a mutation in the ALMS1 gene. clinically characterized multisystem involvement, including sensorineural deafness, cone-rod dystrophy, nystagmus, obesity, insulin resistance, type 2 diabetes and hypogonadism. The diagnosis thus challenging for patients without this characteristic set of clinical symptoms. We explored effectiveness whole-exome sequencing syndrome. Methods A girl with symptoms was tested diagnosed...
Abstract Recent advancement in Genome-wide Association Studies (GWAS) comes from not only increasingly larger sample sizes but also the shifted focus towards underrepresented populations. Multi-population GWAS may increase power to detect novel risk variants and improve fine-mapping resolution by leveraging evidence diverse populations accounting for difference linkage disequilibrium (LD) across ethnic groups. Here, we expand upon our previous approach single-population through Joint...
Internalizing and externalizing problems are the most prevalent health among adolescents. However, few studies have examined co-occurring internalizing from a longitudinal perspective.A total of 1051 seventh-grade students two junior high schools were recruited at baseline. Among them, 932 valid participants reassessed 1 year 2 years later. Data analyzed using parallel-process latent class growth analysis multinominal logistic regression.Four joint trajectories identified. Compared with...
Abstract In this article, we propose the eigen higher criticism and Berk–Jones testing procedures to test association between a single genetic variant multiple correlated traits based on summary statistics from single‐trait genome‐wide studies. Since pattern each varies across whole genome, further develop an omnibus (OMNI) using aggregated Cauchy achieve more robust performance. The p values of our proposed tests can be computed analytically, thus, methods are appealing in large‐scale...
Metaphors are not only commonly used in literature to captivate readers, but also serve broader pragmatic purposes. However, translating metaphors between languages and cultures faces challenges due linguistic cultural differences. This study analyses the English translation of MAO TSE-TUNG’s Spring a Pleasure Garden, The Long March Pure Serene Music·Spiral Mountain, aiming discuss characteristics metaphor Xu Yuanchong’s translation, find difficulties so as summarize strategies. It is found...
ABSTRACT Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome interest. Despite wide uses various popular two-sample MR methods based genome-wide association study summary level data, however, those could suffer from potential power loss or/and biased inference when chosen are in linkage disequilibrium (LD), and also have relatively large direct effects whose...
A blended synchronous classroom (BSC), aiming to promote education fairness, is a new teaching mode that utilizes rich media technology connect two or more classrooms take the same lesson. BSC promotes learners' cognition through collaborative interaction of multiple subjects, with multi-directionality interpersonal interactions and complexity cognitive engagement. However, there are few effective studies on effect bidirectional influence between engagement in BSC. This study proposed coding...
Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome interest. Despite wide uses various popular two-sample MR methods based genome-wide association study summary level data, however, those could suffer from potential power loss or/and biased inference when chosen are in linkage disequilibrium (LD), and also have relatively large direct effects whose distribution might...