A5010800780- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Skin and Cellular Biology Research
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Simulation and Modeling Applications
- Quantum Dots Synthesis And Properties
- Integrated Circuits and Semiconductor Failure Analysis
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Video Analysis and Summarization
- Hair Growth and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
Chengdu University of Information Technology
2025
Ruijin Hospital
2009-2023
Shanghai Jiao Tong University
2010-2023
NIHR Birmingham Liver Biomedical Research Unit
2022
Institute of Virology of the Slovak Academy of Sciences
2022
University of Michigan
2015
VA Ann Arbor Healthcare System
2015
Shanghai Ninth People's Hospital
2013-2015
Zero to Three
2011
Nirmatrelvir-ritonavir has been authorized for emergency use by many countries the treatment of coronavirus disease 2019 (Covid-19). However, supply falls short global demand, which creates a need more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome 2 (SARS-CoV-2).We conducted phase 3, noninferiority, observer-blinded, randomized trial during outbreak caused B.1.1.529 (omicron) variant SARS-CoV-2. Symptomatic adults mild-to-moderate...
Hepatitis B virus infection is still a major global health problem, despite decades of research. Interleukin (IL)-22 induces acute phase reactants and chemokines, favors anti-microbial defence protects tissues from damage. IL-22 important in chronic skin inflammation, but its role hepatitis (CHB) unclear. This study explores the association between intra-hepatic expression, relevant associated cytokines severity liver inflammation/fibrosis CHB patients. IL-22, IL-17, IL-10, IL-6, non-ELR-CXC...
Aiming at the problem that most of current multi-view clustering methods only focus on information a single view, ignoring correlation between views, and failing to fully explore potential structure data, method combining dynamic fusion non-negative matrix factorization is proposed. First, we extract low-dimensional feature representations for each view using enhance consistency across different views through contrastive learning. Second, apply continual learning strategy dynamically update...
Abstract In this paper, in order to enhance the MRI diagnosis of myocarditis, a generative adversarial network (GAN)-based diagnostic model for myocarditis is constructed paper. The images provided by hospital were used as data source study, and image format was transformed into NII file saving using Python tool, which uniformly cropped 480×768 pixels, stored form datasets, divided dataset A (the MRI-weighted dataset) B myocarditis). ResNet-34 U-Net generator discriminator, respectively,...
Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is responsible for viral persistence. This study aimed to investigate the serum surrogate markers cccDNA and evaluate intrahepatic events associated with disease activity in HBeAg‐negative chronic hepatitis patients. Thirty‐three treatment‐naïve patients a negative HBeAg who had liver biopsy were studied. Active was defined as alanine aminotransferase >40 IU/L HBV >10,000 copies/ml. showed significant correlation...
Summary. Current guidelines recommend antiviral therapy for chronic hepatitis B (CHB) patients with elevated alanine aminotransferase (ALT) and high viral load. Scant histological data exist CHB persistently normal ALT (PNALT) because disease progression is thought to be rare. To identify potential predictors of significant histology in the presence PNALT, we compared clinical characteristics Chinese PNALT those ALT. Percutaneous liver biopsy was performed 522 ethnicity who had not...
Inactive chronic hepatitis B (CHB) carriers make up the largest group of virus-infected patients, and China bears total CHB burden any country. We therefore assessed population health impact cost-effectiveness a strategy lifelong monitoring for inactive treatment eligible patients in Shanghai, China. used computer simulation model to project outcomes among cohort based on age-specific prevalence surface antigen (HBsAg), e (HBeAg), cirrhosis. Using Markov we simulated patients' progression...
The effect of nucleos(t)ide analogs (NAs) versus interferon (IFN) on the occurrence hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) is controversial. We assessed whether antiviral strategy affected HCC development CHB patients at different risks.1112 with therapy were included this retrospective study. Patients treated NAs only classified into group (n = 682) while those received IFN treatment or without defined as 430). Propensity score matching (PSM) was applied to minimize...
Safety data reported from the large-scale clinical trials of coronavirus disease 2019 (COVID-19) vaccine are extremely limited in patients with decompensated cirrhosis. The vaccination campaign this specific population could be difficult due to uncertainty about adverse events following vaccination. We aimed assessed COVID-19 rate, factors associated unvaccinated status, and cirrhosis.This is a retrospective study Ruijin Hospial (Shanghai, China) on an ongoing prospective cohort designed for...
Abstract Background With the variability in emerging data, guidance on isolation duration for patients with coronavirus disease 2019 (COVID-19) due to Omicron variant is controversial. This study aimed determine predictors of prolonged viral RNA shedding non-severe COVID-19 and construct a nomogram predict at risk 14-day PCR conversion failure. Methods Adult were enrolled from three hospitals eastern China Spring 2022. Viral time (VST) was defined as either day first positive test or symptom...
Background: We previously reported on serum N-glycans as markers for the diagnosis of cirrhosis in patients with chronic hepatitis C infection. Our present study aimed to evaluate use glycan liver fibrosis B Methods: Patients virus (HBV) infection (n=173) were diagnosed by clinical laboratory analysis and histological examination. Liver was staged using Ishak score. N-glycan profiles proteins determined DNA sequencer-based carbohydrate analytical profiling. Results: found that HBV patients,...
Background and Aims: To evaluate the efficacy of Fuzheng Huayu (FZHY), a Chinese herbal formula, plus entecavir (ETV) in regression liver fibrosis chronic hepatitis B (CHB) patients with significant fibrosis/cirrhosis. Methods: The current study was two-center, randomized, double-blind placebo-controlled pilot study. Fifty-two currently untreated Ishak score ≥3 points were identified 1:1 randomized into FZHY ETV combination placebo groups. second biopsy performed after 48-week treatment....
Serological markers are important for the diagnosis of hepatitis E virus (HEV) infection. This study aims to compare diagnostic performance anti-HEV IgM and HEV antigen (Ag) assays establish a multifactorial model improve current infection when RNA detection is not available.
Background and Aim: A prediction model of hepatocellular carcinoma (HCC) risk in patients with chronic liver diseases, based on age, male sex, albumin-bilirubin, platelets (aMAP), has been previously reported. We validated the aMAP score compared its performance to those other scores an independent at-risk cohort. Methods: Treatment-naïve hepatitis B-related compensated cirrhosis who received entecavir or tenofovir monotherapy for at least 12 months were enrolled this study. The performances...
Chronic hepatitis B (CHB) can cause liver fibrosis and lead to cirrhosis cancer. As the effectiveness of antiviral therapy reverse is limited, We aimed evaluate effect An-Luo-Hua-Xian pill (ALHX) on regression in CHB patients treated with entecavir (ETV).Treatment-naïve were randomly ETV alone or combined ALHX (ETV+ALHX) between October 1, 2013 December 31, 2020. Demographic, laboratory, histology data before after 78 weeks treatment collected. The Ishak score (F) was used required a...
Pseudogenes are barely transcribed at normal, while the anomalous transcripts of them mostly regarded as long non-coding RNAs (lncRNAs), which play potential functions in human tumorigenicity and development. The exact effects pseudogene-derived on hepatocellular carcinoma (HCC) ambiguous. According to our previous research constructed database HCC-related lncRNAs, we noticed that UBE2MP1 was transcriptionally activated HCC a pseudogene from ubiquitin-conjugating enzyme member UBE2M. In this...
Evaluation of liver fibrosis played a monumental role in the diagnosis and monitoring chronic hepatitis B (CHB). We aimed to explore value serum N-glycan markers fibrosis.
To explore the categories of drugs causing hepatotoxicity and analyze clinical histological features corresponding drug-induced liver injury (DILI), in order to gain insights into potential diagnostic factors for DILI.A total 138 DILI patients treated at our hospital from April 2008 2010 were retrospectively analyzed. The responsible drug each case was recorded. Roussel Uclaf Causality Assessment Method (RUCAM) had been used diagnose DILI. Only cases that scored as highly probable or (more...
Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C). The challenge for more than 70 IF-associated diseases is the lack of clinically utilized IF-targeted therapies. We used high-throughput drug screening identify compounds that normalized mutation-triggered disruption. Parthenolide, a plant sesquiterpene...