A5045571402- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Graphene research and applications
- 2D Materials and Applications
- Sepsis Diagnosis and Treatment
- Distributed systems and fault tolerance
- Advanced Glycation End Products research
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cognitive Functions and Memory
- Perovskite Materials and Applications
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Parallel Computing and Optimization Techniques
- Phase Change Materials Research
- Advanced Data Storage Technologies
- Security and Verification in Computing
- Strong Light-Matter Interactions
- MXene and MAX Phase Materials
- Cloud Data Security Solutions
- Advanced Queuing Theory Analysis
- Complexity and Algorithms in Graphs
- Hemodynamic Monitoring and Therapy
- Immune cells in cancer
Renji Hospital
2015-2025
Shanghai Jiao Tong University
2013-2025
Columbia University
2023
Dalian Maritime University
2020-2022
Fudan University
2020
University of Electronic Science and Technology of China
2020
First People's Hospital of Yunnan Province
2018
University of Oxford
2014-2017
National Natural Science Foundation of China
2016
Shanghai University of Electric Power
2016
We present an atomic resolution structural study of covalently bonded dopant pairs in the lattice monolayer graphene. Two iron (Fe) metal atoms that are within graphene observed and their interaction with each other is investigated. The two atom dopants can form small paired clusters varied geometry vacancy defects. Fe created a 10 nm diameter predefined location by manipulating focused electron beam (80 kV) on surface containing intentionally deposited precursor reservoir....
ABSTRACT Macrophages play a key role in the development of sepsis-induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that glycolysis plays an important regulating macrophage polarization through metabolic reprogramming. Bone marrow mesenchymal stem cells (BMSCs) can alleviate lung injury and possess potent immunomodulatory immunosuppressive properties via secreting exosomes. However, it is unknown whether BMSCs-derived exosomes exert their therapeutic effect...
Understanding the stability of monolayer transition metal dichalcogenides in atmospheric conditions has important consequences for their handling, life-span, and utilization applications. We show that cryogenic photoluminescence spectroscopy (PL) is a highly sensitive technique to detection oxidation induced degradation tungsten disulfide (WS2) caused by exposure ambient conditions. Although long-term causes massive from optically visible, short-term produces no obvious changes PL or Raman...
Pulmonary fibrosis is characterized by lung fibroblast proliferation and collagen secretion. In lipopolysaccharide (LPS)-induced acute injury (ALI), aberrant of fibroblasts initiated in early disease stages, but the underlying mechanism remains unknown. this study, we knocked down Toll-like receptor 4 (TLR4) expression cultured mouse using TLR4-siRNA-lentivirus order to investigate effects LPS challenge on proliferation, phosphoinositide3-kinase (PI3K)-Akt pathway activation, phosphatase...
Abstract Exciton-polaritons are quasiparticles consisting of a linear superposition photonic and excitonic states, offering potential for nonlinear optical devices. The component the polariton provides finite Coulomb scattering cross section, such that different types exciton found in organic materials (Frenkel) inorganic (Wannier-Mott) produce polaritons with interparticle interaction strength. A hybrid state distinct excitons technological route towards situ control behaviour. Here we...
Monolayer transition metal dichalcogenides (TMDs) are direct band gap semiconductors, and their 2D structure results in large binding energies for excitons, trions, biexcitons. The ability to explore many-body effects these monolayered structures has made them appealing future optoelectronic photonic applications. changes bilayer TMDs with increased contributions from indirect transitions, this limited similar in-depth studies of Here, we study biexciton emission WS2 grown by chemical vapor...
We study the interactions in graphene/WS2 two-dimensional (2D) layered vertical heterostructures with variations areal coverage of graphene by WS2. All 2D materials were grown chemical vapor deposition and transferred layer layer. Photoluminescence (PL) spectroscopy WS2 on showed PL quenching along an increase ratio exciton/trion emission, relative to SiO2 surface, indicating a reduction n-type doping levels as well reduced radiative recombination quantum yield. Electrical measurements total...
Background: Acute kidney injury (AKI) is a prevalent and serious complication among patients with sepsis-associated acute respiratory distress syndrome (ARDS). Prompt accurate prediction of AKI has an important role in timely intervention, ultimately improving the patients' survival rate. This study aimed to establish machine learning models predict via thorough analysis data derived from electronic medical records. Method: The eligible were retrospectively collected Medical Information Mart...
Abstract Background Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced fibroblast activation and collagen secretion vitro. However, its effects on the process of lung fibrosis initiation during LPS induced acute injury (ALI) remain unknown. The goal present study was to determine effect inhibiting TLR4 LPS-induced ALI vivo. Methods model established by intraperitoneal injection mice. TLR4-small hairpin RNA (shRNA) lentivirus injected intravenously into mice inhibit...
Background Acute lung injury (ALI) is considered to be the major cause of respiratory failure in critically ill patients. Clinical studies have found that patients with sepsis and after hemorrhage, elevated level high mobility group box-1(HMGB-1) their circulation highly associated ALI, but underlying mechanism remains unclear. Extracellular HMGB-1 has cytokine-like properties can bind Toll-like Receptor-4 (TLR4), which was reported play an important role pathogenesis ALI. The aim this study...
Large single-crystal domains of WS2 are grown by chemical vapor deposition, and their photoluminescent properties under a lateral electric field studied. We demonstrate that monolayer bilayer have opposite responses to fields, with photoluminescence (PL) substantially reduced in increased bilayers increasing strength. Temperature-dependent PL measurements also undertaken show behavior distinctly different than the effects, ruling out heating as cause changes. The variation both is attributed...
Lipopolysaccharide (LPS)-induced autophagy inhibition in lung fibroblasts is closely associated with the activation of phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin (PI3K-Akt-mTOR) pathway. However, underlying mechanism remains unknown. In this study, we demonstrated that LPS activated PI3K-Akt-mTOR pathway and inhibited fibroblast by depleting thymocyte differentiation antigen-1 (Thy-1) upregulating integrin β3 (Itgb3). Challenge human MRC-5 cell line resulted...
Gram-negative bacillus infection is an important risk factor of acute lung injury (ALI). Previous experiments have revealed that lipopolysaccharide (LPS), a primary component endotoxin gram-negative bacilli, stimulated the inflammatory reactions contribute to ALI and pulmonary interstitial fibrosis, but mechanisms were not well understood. We reported LPS was able directly induce secretion collagen in mouse fibroblasts via activation phosphoinositide3-kinase-Akt (PI3K-Akt) pathway through...
Recently, deep learning is emerging as a powerful tool and has become leading machine in computer vision image analysis. In this survey paper, we provide snapshot of fast-growing field, classification, specifically. We briefly introduce several popular neutral networks summarize their applications classification. addition, also discuss the challenge
Background: Mechanical ventilation (MV) can induce pulmonary fibrosis. This study aims to investigate whether MV-induced fibrosis is associated with aerobic glycolysis and seeks uncover the underlying mechanisms mediated by integrin β3-pyruvate kinase M2 (PKM2) pathway. Methods: PKM2 knockdown or inhibition, β3 knockout inhibition wild-type mice were exposed MV (20 mL/kg) for 2 h. Results: Mice exhibited increased expression of collagen deposition, upregulation α-smooth muscle actin I in...
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high incidence and mortality rate in intensive care unit (ICU) admissions. Early identification of patients at risk for developing ARDS crucial timely intervention improved clinical outcomes. However, the complex pathophysiology makes early prediction challenging. This study aimed to develop an artificial intelligence (AI) model automated lung lesion segmentation facilitate unit.