A5048299096- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Zebrafish Biomedical Research Applications
- Gut microbiota and health
- Prenatal Substance Exposure Effects
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Metabolomics and Mass Spectrometry Studies
- Structural Behavior of Reinforced Concrete
- Quasicrystal Structures and Properties
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Amino Acid Enzymes and Metabolism
- Electrical Contact Performance and Analysis
- Forensic Toxicology and Drug Analysis
- Intermetallics and Advanced Alloy Properties
- Aluminum Alloys Composites Properties
- Lubricants and Their Additives
Nanjing University of Chinese Medicine
2020-2025
Xiamen University
2025
Fujian Medical University
2025
Fujian University of Traditional Chinese Medicine
2025
Guangdong University of Technology
2020
Gegen Qinlian Decoction (GQD) is a classical traditional Chinese medicine (TCM) formula primarily utilized for treating gut disorders. GQD showed therapeutic effects on several diseases in clinical and animal studies by targeting microbes. Our recent also found that efficiently alleviated anxiety methamphetamine-withdrawn mice via regulating microbiome metabolism. Given various have indicated the link between development of depression, here we endeavor to explore whether can manage...
Abstract Background The aim of the study was to explore a feasible method for alleviating limb ischemia–reperfusion injury (LI/RI) through use high‐concentration citrate solution (HC‐A solution) perfusion (LP). Methods Eighteen pigs were divided into three groups: Sham group, LI/RI and HCA group. group underwent exposure iliac artery vein. tourniquet placement clamping vein simulate LI/RI. received HC‐A LP 30 min left below level blood flow occlusion based on Oxidative stress markers...
Abstract Parental substance abuse increases the risk of neurological and psychiatric disorders in offsprings. However, its underlying mechanism remains elusive. Our previous study demonstrated that long‐term exposure to methamphetamine (Meth), a psychostimulant drug with high addiction potential, remarkably alters gut microbiome metabolites male mice, which contribute Meth‐induced anxiety‐like behaviors. The current aimed investigate whether microbiota metabolism serve as potential...
Abstract Background This study aims to investigate the differences in postoperative prognosis associated with single nucleotide polymorphism (SNP) rs2228226 (G > C) gastric adenocarcinoma (GAC) patients. Methods enrolled 661 patients locally advanced (pT4a) GAC after surgery. DNA was extracted from their tissues and genotyped for using a MassARRAY Analyzer. Based on patients’ clinical pathological information, multifactorial Cox regression analysis performed assess correlation between of...
Abstract Methamphetamine (METH) is a commonly abused addictive psychostimulant, and METH‐induced neurotoxic behavioural deficits are in sex‐specific manner. However, there lack of biomarkers to evaluate METH addiction clinical practice, especially for gender differences. We utilized ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) detect the serum metabolomics addicts controls, specially exploring metabolic alterations by abuse. found that many differently...
Paternal methamphetamine (METH) exposure results in long-term behavioural deficits the sub-generations with a sex difference. Here, we aim to investigate sex-specific neurobehavioural outcomes first-generation offspring mice (F1 mice) paternally exposed METH prior conception and explore underlying brain mechanisms. We found that paternal increased anxiety-like behaviours spatial memory only female F1 caused depression-like without differences. In parallel, METH-sired exhibited activity...
Abstract Methamphetamine (METH) is a common abused drug. METH‐triggered glutamate (Glu) levels in dorsal CA1 (dCA1) could partially explain the etiology of METH‐caused abnormal memory, but synaptic mechanism remains unclear. Here, we found that METH withdrawal disrupted spatial memory mice, accompanied by increases Glu and postsynaptic neuronal activities at dCA1 synapses. weakened capacity clearance astrocytes, as indicated increasing A1‐like astrocytes phosphorylated signal transducer...
Paternal abuse of drugs, such as methamphetamine (METH), elevates the risk developing addiction in subsequent generations, however, its underlying molecular mechanism remains poorly understood. Male adult mice (F0) were exposed to METH for 30 days, followed by mating with naïve female create first-generation (F1). When growing adulthood, F1 subjected conditioned place preference (CPP) test. Subthreshold dose (sd-METH), insufficient induce CPP normally, used F1. Selective antagonist...
Cerebellum has been implicated in drug addiction; however, its underlying cellular populations and neuronal circuitry remain largely unknown. In the current study, we identified a neural pathway from tyrosine hydroxylase (TH)–positive Purkinje cells (PC TH+ ) cerebellar lobule VI to calcium/calmodulin-dependent protein kinase II (CaMKII)–positive glutamatergic neurons medial nucleus (Med CaMKII ), forming PC –Med male mice. naive mice, inhibition of activated Med neurons. During conditioned...
Simulation results showed that the optimal Y-doping ratio was 16.7%, and experimental verification using X-ray diffraction confirmed replacement cell model established by simulation. AgSnO2 Y-doped electrical contact material were tested under 24V/15A DC resistance load for 40,000 cycles. The erosion morphology of at different times observed 3D surface profilometer, waveforms arc voltage, current, force also analyzed. SnO2 preferentially evaporates arc, inhibiting evaporation Ag, which in...
ABSTRACT Methamphetamine (METH) is frequently abused drug and produces cognitive deficits. METH could induce hyper-glutamatergic state in the brain, which partially explain METH-related deficits, but synaptic etiology remains incompletely understood. To address this issue, we explored role of dCA1 tripartite synapses potential therapeutic effects electro-acupuncture (EA) development withdrawal-induced spatial memory deficits mice. We found that withdrawal weakened astrocytic capacity...
Abstract The cerebellum is implicated in drug addiction. However, the cerebellar neuronal circuitry underlying addiction, especially classic pathway of Purkinje cells (PCs) to deep nuclei (DCN), are largely unknown. Here, tracing experiments showed robust projections from lobule VI tyrosine hydroxylase (TH)-positive PCs (PC TH+ ) CaMKII-positive glutamatergic neurons medial nucleus (Med CaMKII ), forming PC –Med pathway. Then, mice were subjected methylamphetamine (METH)-induced conditioned...
Abstract Adolescent cocaine abuse increases the risk for developing addiction in later life, which remains a big public health concern, but underlying molecular mechanism is poorly understood. Here, adolescent cocaine-exposed (ACE) male mice models were established by administrating during period. When growing to adult age, subjected conditioned place preference (CPP) evaluate sensitivity cocaine, then potential molecule of dual specificity phosphatase 1 (DUSP1) screened out transcriptomic...
ABSTRACT Paternal abuse of drugs, such as methamphetamine (METH), elevates the risk developing addiction in subsequent generations, however, its underlying molecular mechanism remains poorly understood. Male adult mice (F0) were exposed to METH for 30 days, followed by mating with naïve female create first-generation (F1). When growing adulthood, F1 subjected conditioned place preference (CPP) test. Subthreshold dose METH, insufficient induce CPP normally, used (METH ). Selective antagonist...
The cerebellum is implicated in drug addiction, but its underlying neuronal circuitry largely unknown. Here, tracing experiments shows robust projections from the cerebellar lobule VI tyrosine hydroxylase (TH)-positive Purkinje cells (PCTH+) to calcium/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons medial nucleus (MedCaMKII), forming PCTH+–MedCaMKII pathway male mice. During behaviors of methylamphetamine (METH)-trained conditioned place preference (CPP),...