A5027784650- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Geological and Geophysical Studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Global Cancer Incidence and Screening
- Hepatitis Viruses Studies and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Birth, Development, and Health
- Apelin-related biomedical research
- Consumer Perception and Purchasing Behavior
- earthquake and tectonic studies
- Stroke Rehabilitation and Recovery
Monash University
2020-2025
Southern University of Science and Technology
2023
Peking University Shenzhen Hospital
2018-2021
Cancer Council Victoria
2019
First Affiliated Hospital of Fujian Medical University
2019
Fujian Medical University
2019
Chinese University of Hong Kong
2018
Geriatric syndromes, multimorbidity, and disability are prevalent among ageing population. However, no study empirically examined their additive or synergistic effect on healthcare use. The present aims to estimate overlapping prevalence of geriatric disability; examine associations these three conditions with A cross-sectional was conducted in community-dwelling older adults aged 60 above 12 Hong Kong districts. Pearson's chi-squared test for trend performed across age groups (60–69, 70–79,...
Importance Lifestyles enriched with socially and mentally stimulating activities in older age may help build cognitive reserve reduce dementia risk. Objective To investigate the association of leisure social networks risk among individuals. Design, Setting, Participants This longitudinal prospective cohort study used population-based data from ASPREE Longitudinal Study Older Persons (ALSOP) for March 1, 2010, to November 30, 2020. Community-dwelling individuals Australia aged 70 years or who...
Long intergenic noncoding RNA-p21 (lincRNA-p21) has been reported to be increased in Parkinson's disease (PD). However, the function and underlying mechanisms of lincRNA-p21 remain not clear. In order explore role PD, we used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induce vivo PD model (C57BL/6 mice) utilized N-methyl-4-phenylpyridinium (MPP+) create vitro (SH-SY5Y cells). Results showed that expression level was significantly models. High abundance inhibited viability promoted...
Brain microvascular endothelial cells (BMECs) are involved in brain vascular dysfunction ischemic stroke. Abnormal expression of circular RNAs regulate physiological and pathophysiological processes the central nervous system. The aim present study was to investigate profile circRNAs human BMECs after oxygen glucose deprivation (OGD), which an vitro model stroke, find promising biomarkers stroke.RNA sequencing (RNA-seq) technology conducted analyze differential between OGD non-OGD treated...
Abstract Introduction This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and association of these trajectories with dementia. Methods Generally healthy older adults (n = 19,114) were followed for up 7 years, regular assessments. Group‐based trajectory modeling identified distinct trajectories. Results Four seven per domain. Stable observed across domains. Improvement in verbal fluency minor psychomotor slowing common. Substantial...
Increasing evidence suggests that stress could be a risk factor for dementia but this might vary by gender. This study investigated whether adverse life events were associated with cognitive decline and in later-life, separately men women. Participants 12,789 community-dwelling Australians aged ≥ 70 years. Ten common later-life self-reported. Cognitive was defined as 1.5 SD from participants' baseline score tests of global cognition, psychomotor speed, episodic memory, executive functioning,...
Importance Poor cardiometabolic health is a risk factor associated with cognitive impairment in later life, but it remains unclear whether trajectories can serve as early markers dementia. Objective To compare that precede dementia diagnosis those among individuals without Design, Setting, and Participants This case-control study analyzed sample drawn from community-dwelling participants the Aspirin Reducing Events Elderly (ASPREE) study. Recruitment through primary care physicians occurred...
The conditions under which samples were collected, processed, and stored in biobanks may influence Alzheimer's disease (AD) biomarker levels. This study aims to investigate whether a range of pre-analytical factors plasma levels AD biomarkers. Data obtained from the ASPREE Healthy Ageing Biobank, cohort healthy community-dwelling older individuals aged 70+ years Australia. Five biomarkers measured using 11,868 individuals: phosphorylated-tau181 (p-tau181), neurofilament light chain (NfL),...
Abstract Objectives The National Institute of Health Stroke Scale (NIHSS) is a predictor for the prognosis acute ischaemic stroke (AIS) and its prediction time-dependent. We examined performance NIHSS at different timepoints in predicting functional outcome patients with thrombolysed AIS. Methods This prospective study included 269 AIS treated recombinant tissue plasminogen activator (rt-PA). Unfavourable was defined as modified Rankin score 4–6 3 months after rt-PA treatment. Receiver...
Abstract Backgrounds There is a discrepancy between west and east on the relationship non-alcoholic fatty liver disease (NAFLD) chronic kidney (CKD). This study aimed to find out possible reason for this clarify association NAFLD CKD by analyzing two population-based datasets from US China. Methods Two health examination China were used. was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m 2 or and/or abnormal albuminuria overt proteinuria. Binary logistic...
Abstract Introduction This study investigated whether grip strength and gait speed predict cognitive aging trajectories examined potential sex‐specific associations. Methods Community‐dwelling older adults ( n = 19,114) were followed for up to 7 years, with regular assessment of global function, episodic memory, psychomotor speed, executive function. Group‐based multi‐trajectory modeling identified joint trajectories. Multinomial logistic regression the association at baseline Results High...
The inter-individual variability in cognitive changes may be early indicators of major health events. We aimed to determine whether late-life trajectories were associated with incident dementia, persistent physical disability and all-cause mortality.Data came from a cohort older community-dwelling individuals aged 70 years or above Australia the United States. Global cognition, verbal fluency, episodic memory psychomotor speed assessed regularly at up seven waves between 2010 2017. Dementia,...
There is variability across individuals in cognitive aging. To investigate the associations of several modifiable factors with high and low performance.Data came from 17,724 community-dwelling aged 65-98 years. Global cognition, verbal fluency, episodic memory, psychomotor speed were assessed over up to seven Group-based multi-trajectory modeling identified distinct trajectories. Structural equation examined direct/indirect social/behavioral chronic conditions trajectories.Seven trajectory...
Abstract Background This study examined the associations of body mass index (BMI) and waist circumference (WC), as well their short‐ long‐term changes over time, with incident dementia in older individuals. Methods Data came from 18,837 community‐dwelling individuals aged 65+ years Australia United States, who were relatively healthy without major cognitive impairment at enrolment. Anthropometric measures prospectively assessed baseline, change variability baseline to year two (three...
Men with prostate cancer experience side effects for which a supportive social environment may be beneficial. We examined the association between four measures of connectedness and mortality after diagnosis. Male participants in Melbourne Collaborative Cohort Study 1990-1994, who developed incident attended follow-up 2003-2007, were eligible study. Information on connectedness, collected at follow-up, included (i) living arrangement; (ii) frequency visits to friends/relatives (iii) from...
The association between the level of body mass index (BMI) and mortality patients with critical liver disease remains unclear. This study aimed to examine BMI hospital acute-on-chronic failure (ACLF).Clinical data from 146 ACLF were collected analyzed. was categorized into three groups: lower (<18.5kg/m2), normal (18.5-24.9kg/m2), overweight (25.0-32.0kg/m2). laboratory parameters measured one day before, or on start treatment. Values compared survivors non-survivors, then rates among...
Background and Aims: The aim of this study was to investigate the effect(s) meteorological factors on prevalence acute-on-chronic liver failure (ACLF) based 10-years' worth population data. Methods: We retrospectively collected ACLF case data from January 2007 December 2016 three major hospitals in Fuzhou City, China. Climatic data, including rainfall, mean temperature, differences temperature (delta temperature) humidity for each month were downloaded China Data Service Center. Following...
Abstract Background Although the importance of body weight in later life for brain health has been established, less is known about shape and composition. This study aims to examine their associations with dementia cognitive changes older adults. Method Data were obtained from over 17,000 community‐dwelling individuals aged 65‐98 years, recruited Australia US. We assessed using ratio waist circumference mass index (WBR), estimated lean (LM) fat (FM) by Hume formula. Dementia diagnosis was...