A5054980802- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Syphilis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Liver Diseases and Immunity
- Long-Term Effects of COVID-19
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Mosquito-borne diseases and control
- Sex work and related issues
- Vitamin D Research Studies
- Drug-Induced Hepatotoxicity and Protection
- HIV/AIDS Research and Interventions
- Gout, Hyperuricemia, Uric Acid
- Healthcare Systems and Reforms
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
Fujian Medical University
1992-2025
First Affiliated Hospital of Fujian Medical University
1992-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Abstract Background and aims Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020, the utility of which has not been tested validated real world. We aimed to compare characteristics MAFLD non‐alcoholic (NAFLD). Methods The data was retrieved from third National Health Nutrition Examination Surveys United States, an unbiased survey dataset frequently used for study disease. Results A total 13 083 cases with completed ultrasonography laboratory were identified...
The coronavirus disease 2019 (COVID-19) has evolved into a pandemic rapidly. Most of the literature show that elevated liver enzymes in COVID-19 are little clinical significance. Lower albumin level is seen severe and not parallel to changes alanine aminotransferase aspartate levels. We aimed explore impact hypoalbuminemia COVID-19. This retrospective cohort study included adult patients with confirmed relationship between death was studied using binary logistic analysis. A total 299 were...
Coronavirus Disease 2019 (COVID-19) has become a pandemic since March 2020. We describe here 2 cases of COVID-19 infection in posttransplant setting. First one is 59-year-old renal transplant recipient; the second 51-year-old allogeneic bone marrow recipient. Both patients were on immunosuppressant therapy and had stable graft function before infection. After diagnosis COVID-19, immunosuppressive agents discontinued methylprednisolone with prophylactic antibiotics initiated, however, lung...
Syphilis is a global public health concern. This study aimed to assess the and regional burden of syphilis from 1990 2019. Disease was evaluated using disability-adjusted life-years (DALYs) prevalence. Data were extracted 2019 disease Study, an open database available for download. Age-standardized rates (ASR) estimated annual percentage changes (EAPC) calculated evaluate over time. In 2019, total number prevalent cases 49.71 million worldwide. The ASR prevalence stable with EAPC 0.00 (95%...
Abstract Background and objectives Dietary control increased physical activity (PA) are recommended for patients with metabolic (dysfunction-) associated fatty liver disease (MAFLD). However, not all can sustain both exercise a healthy diet. This study explored the interaction between dietary quality, PA levels, mortality in MAFLD patients. Methods The Third National Health Nutrition Examination Survey linked data were used this study. Diet quality was assessed Healthy Eating Index (HEI)....
The coronavirus disease 2019 (COVID-19) has evolved into a pandemic rapidly. majority of COVID-19 patients are with mild syndromes. This study aimed to develop models for predicting progression in cases. risk factors the requirement oxygen support were explored using multivariate logistic regression. Nomogram as visualization was developed R software. A total 344 included final analysis, 45 whom progressed and needed high-flow therapy or mechanical ventilation after admission. There 188...
Metabolic associated fatty liver disease (MAFLD) is diagnosed in patients with hepatic steatosis when they have the following three metabolic conditions: obesity/overweight, diabetes and dysregulation, either alone or combination. There no clarity whether subtypes of MAFLD by different conditions carry levels risk for intra- extra-hepatic organs. This study aims to depict characteristics these a large population.The data were retrieved from third National Health Nutrition Examination Surveys...
Abstract Uric acid (UA) is associated with non-alcoholic fatty liver disease (NAFLD). However, it unclear whether UA plays a predictive role in NAFLD prognosis. This study aimed to explore the relationship between levels and mortality patients without severe renal disease. Data were obtained from Third National Health Nutrition Examination Survey (NHANES). Time-dependent Cox regression was used estimate hazard ratio (HR) 95% confidence interval (CI) for mortality. Overall, 2493 individuals...
Background and Aims: Circadian misalignment (CM) leads to metabolic disorder. Metabolic (dysfunction) associated fatty liver disease (MAFLD) is a novel definition for that requires the presence of dysfunction. As association between CM MAFLD remains unclear, this study designed explore whether there an MAFLD. Methods: NHANES 2017– 2018 database was used in study. Liver steatosis fibrosis were diagnosed by Fibroscan ® . defined mistimed sleep, late sleep or irregular chronotype. Propensity...
Non-invasive hepatic steatosis algorithms are recommended in detecting metabolic-associated fatty liver disease (MAFLD) epidemiological studies. However, the diagnostic accuracy of these models is unclear. This study aimed to evaluate efficiency five common a national survey population.The Third National Health and Nutrition Examination Survey (NHANES III) datasets were used this study. The index (FLI), (HSI), non-alcoholic disease-liver fat score (NAFLD-LFS), steato text (ST), visceral...
Abstract Data on the global epidemiology of varicella‐zoster virus infection (VZVI) is limited. This study aimed to investigate burden VZVI based disease 2019 data. The age‐standardized rates, including incidence, death, disability‐adjusted life years (DALYs), and estimated annual percentage changes (EAPC) were calculated evaluate VZVI. numbers incident death cases due 83 963 744 14 553, respectively. incidence rate increased slightly all over world, while DALYs decreased from 1990 (EAPC =...
BACKGROUNDNon-invasive fibrosis scores are not yet validated in the newly defined metabolic associated fatty liver disease (MAFLD). AIMTo evaluate diagnostic performance of four non-invasive including aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 (FIB-4), body mass index, aminotransferase/alanine ratio, diabetes score (BARD), and nonalcoholic (NFS) patients with MAFLD. METHODSConsecutive histologically confirmed MAFLD were included.The discrimination ability different...
Human immune deficiency virus (HIV)/acquired syndrome (AIDS) and syphilis are the most common sexually transmitted diseases (STDs) worldwide, as well in China. The objective of this study is to describe trend spatial temporal variation HIV/AIDS mainland China from 2007 2017. Stratified analysis was conducted according age GDP per capita. Estimated Annual Percentage Change (EAPC) calculated autocorrelation used evaluate epidemiology identify clusters. morbidity new HIV infection increased...
Malaria poses significant public health challenges and huge disease economic burdens across the world, notably in low-income countries. Although great strides have been achieved, COVID-19 pandemic hinders progress towards global elimination of malaria. This study utilizes data from burden 2021 sources to assess trends incidence mortality of, disability-adjusted life years (DALYs) lost due malaria before after pandemic, projects 2030 at international, regional national levels. The...
Abstract Backgrounds There is a discrepancy between west and east on the relationship non-alcoholic fatty liver disease (NAFLD) chronic kidney (CKD). This study aimed to find out possible reason for this clarify association NAFLD CKD by analyzing two population-based datasets from US China. Methods Two health examination China were used. was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m 2 or and/or abnormal albuminuria overt proteinuria. Binary logistic...
Abstract Background We aimed to explore the impact of hepatitis B virus (HBV) infection on prevalence nonalcoholic fatty liver disease (NAFLD) based clinical big data. Methods Data were collected from health examination center First Affiliated Hospital Fujian Medical University. Univariate and multivariate analysis applied investigate relationship between HBV NAFLD. Results A total 14 452 patients included, with an average age 43.84 ± 13.03 years. Cases current infection, past noninfection...
There is an immediate need for non-invasive accurate tests diagnosing liver fibrosis in patients with non-alcoholic steatohepatitis (NASH). Previously, it has been suggested that MACK-3 (a formula combines homeostasis model assessment-insulin resistance serum aspartate aminotransferase and cytokeratin [CK]18-M30 levels) accurately identifies fibrotic NASH. Our aim was to assess the performance of develop a novel, algorithm NASH.Six hundred thirty-six adults biopsy-proven fatty disease...