A5052366874- Cardiac Arrest and Resuscitation
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Sepsis Diagnosis and Treatment
- Hemoglobin structure and function
- Venous Thromboembolism Diagnosis and Management
- Immune Response and Inflammation
- Intracerebral and Subarachnoid Hemorrhage Research
- Trauma Management and Diagnosis
- Hemoglobinopathies and Related Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Disaster Response and Management
- Congenital Diaphragmatic Hernia Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Hemanext (United States)
2021-2024
Einstein Medical Center Philadelphia
2017-2021
Einstein Healthcare Network
2020
University of California System
2020
University of California, Irvine
2020
Parkland Memorial Hospital
2020
American College of Physicians
2020
American College of Allergy, Asthma and Immunology
2020
American Academy of Allergy, Asthma and Immunology
2020
CSL (United States)
2015-2019
This study aimed to analyze the relation of hyperglycemia outcome in cases severe traumatic brain injury, and examine factors that may be responsible for hyperglycemic state.A retrospective analysis an intensive care unit a level 1 trauma center investigated 77 patients with injury. Patients Glasgow Coma Scale (GCS) 8 or lower who survived more than 5 days were reviewed. Serum glucose, base deficit, GCS, use steroids, amounts insulin carbohydrates recorded days, along age. The Injury...
Traumatic brain injury (TBI) can be compounded by physiologic derangements that produce secondary injury. The purpose of this study is to elucidate the frequency with which factors are associated occur in patients severe closed head injuries and determine impact these on outcome.The records 81 adult blunt trauma Glasgow Coma Scale scores < or = 8 transport times 2 hours a Level I center were retrospectively reviewed searching for following 11 (SBIFs) first 24 postinjury: hypotension,...
The clinical introduction of new oral anticoagulants (NOACs) has stimulated the development tests to quantify effects these drugs and manage complications associated with their use. Until recently, only treatment choices for prevention venous thromboembolism in orthopedic surgical patients, as well stroke systemic embolism patients atrial fibrillation, were vitamin K antagonists, antiplatelet drugs, unfractionated low-molecular-weight heparins. With approval NOACs, options consequent...
Studies suggest that thoracic computed tomography (TCT) is superior to plain chest X-ray (CXR) in the detection of blunt injury. This study examined whether TCT provides additional information routine CXR findings, results a management change, and more useful patients with particular mechanisms Level I trauma were prospectively placed into two groups. Control (CTL) group underwent as result either clinical symptoms or abnormal findings. The mechanism (MECH) contained who had no signs...
Study objectiveWe evaluated thromboembolic events after vitamin K antagonist reversal in post hoc analyses of pooled data from 2 randomized trials comparing 4-factor prothrombin complex concentrate (4F-PCC) (Beriplex/Kcentra) with plasma.MethodsUnblinded investigators identified events, using standardized terms (such as "myocardial infarction," "deep vein thrombosis," "pulmonary embolism," and "ischemic stroke"). A blinded safety adjudication board reviewed serious well those referred by an...
The "contrast blush" (CB) computed tomographic (CT) scan finding has often been used clinically as an indicator for therapeutic splenic intervention (SI) (splenectomy, splenorrhaphy, or angiographic embolization). We sought to examine the prognostic significance of this finding.The records and CT scans 324 trauma patients from two Level I centers who had blunt injury a abdomen within 24 hours admission were reviewed screened CB.CB was identified in 11% patients, its incidence significantly...
Hemorrhagic shock (HS) initiates an inflammatory cascade that includes the production of cytokines and recruitment neutrophils (PMN) may progress to organ failure, inducing acute respiratory distress syndrome (ARDS). To examine hypothesis interleukin-6 (IL-6) contributes PMN infiltration lung damage in HS, we examined lungs rats subjected unresuscitated resuscitated HS for IL-6 activation Stat3. Using semiquantitative RT-PCR, found a striking increase mRNA levels only with peak observed 1 h...
Prolonged intensive care unit lengths of stay (ICU LOS) for critical illness can have acceptable mortality rates and quality life despite significant costs. Only a few studies specifically addressed prolonged ICU LOS after trauma. Our goals were to examine characteristics outcomes trauma patients with >or= 30 days, predictors mortality.All admissions over seven-year period in level 1 center analyzed. Admission characteristics, pre-existing conditions acquired complications the recorded....
Selection of study endpoints is one the most important decisions in design effective clinical trials. Late mortality (e.g., 28 days) an unambiguous endpoint, accepted by regulatory agencies, but it viewed as problematic among researchers resuscitation for acute trauma injury with hemorrhagic shock. In February 2008, physicians, ethicists, statisticians, and research scientists from military, academia, industry, Federal Drug Administration, National Heart Lung Blood Institute gathered to...
Beta thalassemia (β-thalassemia) is part of a group inherited hemoglobinopathies caused by mutation in the beta globin gene, leading to minimal functional hemoglobin and resulting damaged red blood cells anemia. β-Thalassemia most common Mediterranean region, South-East Asia, Indian subcontinent, Middle East. Many these regions include low- middle-income countries where there are significant unmet needs adequate care management thalassemia. Patients with transfusion-dependent β-thalassemia,...
Background A Level I trauma center recently underwent a policy change wherein airway management of the patient is under auspices Emergency Medicine (EM) rather than Anesthesiology. Methods We prospectively collected data on 11 months EM intubations (EMI) since this and compared them to last year Anesthesia-managed (ANI) answer following questions: (1) Is intubation patients being accomplished effectively by EM? (2) Has there been in complication rates change? (3) How does rate at our compare...
The impact of antithrombotic agents (warfarin, clopidogrel, ASA) on traumatic brain injury outcomes is highly controversial. Although cerebral atrophy speculated as a risk for acute intracranial hemorrhage, there no objective literature evidence.This retrospective, consecutive investigation patients with signs external head trauma and age ≥60 years. Outcomes were correlated antithrombotic-agent status, coagulation test results, admission neurologic function, CT-based dimensions.Of 198...
This study aims to investigate the effects of hypoxically stored Red Blood Cells (RBCs) in a rat model traumatic brain injury followed by severe hemorrhagic shock and resuscitation. RBCs were made hypoxic using an O2 depletion system (Hemanext Inc. Lexington, MA) for 3 weeks. Experimental group animals underwent craniotomy blunt HS. Rats resuscitated with either fresh (FRBCs), 3-week-old (HRBCs), or conventionally (CRBCs). Resuscitation was provided via RBC transfusion equivalent 70 % shed...
Bernard, Andrew C. MD; Moore, Ernest E. Frederick A. Hides, George BA; Guthrie, Brian J. BS; Omert, Laurel Gould, Steven MD The PolyHeme Study Group Author Information
Abstract Aims The aim of this study was to provide recommendations for training patients with hereditary angioedema, based on nursing clinical trial experience, self‐administer subcutaneous C1‐INH (C1‐INH[SC]) used as routine prophylaxis. Background A volume‐reduced, concentrate (C1‐INH(SC); HAEGARDA®; CSL Behring) recently FDA‐approved the prevention angioedema attacks. Nurses will play an important role in patient training. Design Review a phase 3, randomized, placebo‐controlled,...
Introduction . To investigate the impact of a 4-factor prothrombin complex concentrate (4F-PCC [Beriplex®/Kcentra®]) versus plasma on “time to procedure” in patients with acute/severe gastrointestinal bleeding requiring rapid vitamin K antagonist (VKA) reversal prior invasive procedure. Methods A post hoc analysis two phase III trials 4F-PCC bleeding. The treatment arms were compared for study volume, infusion times, and time from start Results Analysis included 42 (plasma, <mml:math...
Polymorphonuclear leukocytes (PMN) and inducible nitric oxide synthase (iNOS) appear to play important roles in the liver lung injury induced by hemorrhagic shock. Their precise shock-induced acute gastric mucosal lesions (AGML), however, are still poorly understood. In this study, we investigated effect of neutropenia on AGML. We also examined iNOS PMN infiltration into mucosa AGML during shock using L-N6--(1 -iminoethyl)-lysine, a potent inhibitor iNOS, reverse transcriptase polymerase...
Objective Traumatic brain injury (TBI) is characterized by damage to the blood-brain barrier, inflammation, and edema formation. In this pilot study, we aimed investigate effects of a complement inhibitor, C1-esterase inhibitor (C1 INH), on inflammation in rat model mild TBI. Methods Thirty-six male Sprague Dawley rats were randomly assigned control, TBI, or TBI plus C1 INH groups. received an injection saline 25 IU/kg INH, respectively, with using weight drop model. Control only. Rats...
Oxidative stress is a major driving force in the development of storage lesions red cell concentrates (RCCs). Unlike manufactured pharmaceuticals, differences component preparation methods and genetic/physiological status donors result nonuniform biochemical characteristics RCCs. Various donated blood on oxygen saturation (SO2 ) distribution were investigated, model to estimate potential oxidative burden stored RCC at transfusion proposed.The content freshly prepared RCCs (770) was...