A5102994531- Anesthesia and Sedative Agents
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Hemoglobin structure and function
- Veterinary Pharmacology and Anesthesia
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Blood donation and transfusion practices
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
- Hemoglobinopathies and Related Disorders
- High Altitude and Hypoxia
- Thermal Regulation in Medicine
- Erythropoietin and Anemia Treatment
- Cardiac Ischemia and Reperfusion
- Inhalation and Respiratory Drug Delivery
- Hemophilia Treatment and Research
- Airway Management and Intubation Techniques
- Blood groups and transfusion
- Platelet Disorders and Treatments
University of California, San Francisco
2014-2024
University of Waterloo
2018-2021
Société Française d'Allergologie
2018
Research Network (United States)
2018
National Heart Lung and Blood Institute
2012-2016
National Institutes of Health
2016
University of Cape Town
2013-2015
Barro Colorado Island
2014
Centre Hospitalier Universitaire Brugmann
2013
Queen Fabiola Children's University Hospital
2013
Context.—Although concern over the risks of red blood cell transfusion has resulted in several practice guidelines for transfusion, lack data regarding physiological effects anemia humans caused uncertainty hemoglobin (Hb) concentration requiring treatment.Objective.—To test hypothesis that acute isovolemic reduction Hb to 50 g/L healthy resting would produce inadequate cardiovascular compensation and result tissue hypoxia secondary oxygen transport.Design.—Before after interventional...
BACKGROUND : A transfusion threshold of 7 g per dL (70 g/L) hemoglobin has been proposed for patients, although scant human data are available to support this recommendation. STUDY DESIGN AND METHODS The medical community's experience with Jehovah's Witnesses was examined, in order assess the lowest tolerable concentration and lower hemoglobin. MEDLINE search conducted capture surgical reports involving from 1970 through early 1993. RESULTS Sixty‐one untransfused concentrations < or = 8...
The low solubility of desflurane in blood and tissues suggests that the partial pressures this agent should approach inspired pressure more rapidly than would tissue other potent inhaled anesthetics. We tested prediction, comparing pharmacokinetics with those isoflurane, halothane, nitrous oxide eight volunteers. measured rate at which alveolar (endtidal) (FA) concentration increased towards an (FI) 65-70%, then concurrent increase FA mixed expired concentrations (FM) desflurane, halothane...
Erythrocytes are transfused to prevent or treat inadequate oxygen delivery resulting from insufficient hemoglobin concentration. Previous studies failed find evidence of systemic at a concentration 5 g/dl. However, in those studies, sensitive, specific measures critical organ function were not used. This study tested the hypothesis that acute severe decreases alters human cognitive function.Nine healthy volunteers, age 29 +/- yr (mean SD), with verbal memory and standard, computerized...
The low solubility of sevoflurane in blood suggests that this agent should enter and leave the body more rapidly than isoflurane. However, closeness isoflurane tissue/blood partition coefficients rates equilibration with elimination from tissues be similar. We tested both predictions, comparing nitrous oxide seven volunteers. measured rate at which alveolar (end-tidal) (FA) concentration increased toward an inspired (FI) 65%–70%, then concurrent rise FA mixed expired concentrations (FM)...
Present package labeling for sevoflurane recommends the use of fresh gas flow rates 2 L/min or more when delivering anesthesia with sevoflurane. This recommendation resulted from a concern about potential nephrotoxicity degradation product sevoflurane, "Compound A," produced by action carbon dioxide absorbents on To assess adequacy this recommendation, we compared 8 h 1.25 minimum alveolar anesthetic concentration (MAC) (n = 10) versus desflurane 9) in fluid-restricted (i.e., nothing mouth...
Desflurane (formerly I-653) is a new inhalaticnal anesthetic with promising pharmacokinetic profile that includes low solubility in blood and tissue, including fat. Since its lipid less than of other volatile agents, it may have lower potency. Low would be expected to increase the rate at which alveolar concentration approaches inspired during induction as well elimination desflurane from emergence. We determined minimum (MAC) 44 unpremedicated ASA physical status 1 or 2 patients undergoing...
Erythrocytes are transfused to treat or prevent imminent inadequate tissue oxygenation. 2,3-diphosphoglycerate concentration decreases and oxygen affinity of hemoglobin increases (P50 decreases) with blood storage, leading some propose that erythrocytes stored for 14 more days do not release sufficient make their transfusion efficacious. The authors tested the hypothesis 3 weeks as effective in supplying human tissues less than 5 h.Nine healthy volunteers donated 2 units before they were a...
The Trauma Hemostasis and Oxygenation Research Network held its third annual Remote Damage Control Resuscitation Symposium in June 2013 Bergen, Norway. is a multidisciplinary group of investigators with common interest improving outcomes safety patients severe traumatic injury. network's mission to reduce the risk morbidity mortality from hemorrhagic shock, prehospital phase resuscitation through research, education, training. concept remote damage control infancy, there significant amount...
Transfusion-related pulmonary complications are leading causes of morbidity and mortality attributed to transfusion. Observational studies suggest an important role for red blood cell (RBC) storage duration in these adverse outcomes.To evaluate the impact RBC on short-term function as well immunologic coagulation status mechanically ventilated patients receiving transfusion.This is a double-blind, randomized, clinical trial comparing fresh (≤5 d storage) versus standard issue single-unit...
Background The "critical" level of oxygen delivery (DO2) is the value below which DO2 fails to satisfy metabolic need for oxygen. No prospective data in healthy, conscious humans define this value. authors reduced healthy volunteers an attempt determine critical DO2. Methods With Institutional Review Board approval and informed consent, studied eight volunteers, aged 19-25 yr. Hemodynamic measurements were obtained at steady state before after profound acute isovolemic hemodilution with 5%...
Present package labeling for sevoflurane recommends the use of fresh gas flow rates 2 L/min or more when delivering anesthesia with sevoflurane.This recommendation resulted from a concern about potential nephrotoxicity degradation product sevoflurane, "Compound A," produced by action carbon dioxide absorbents on sevoflurane. To assess adequacy this recommendation, we compared 8 h 1.25 minimum alveolar anesthetic concentration (MAC) (n = 10) versus desflurane 9) in fluid-restricted (i.e.,...