A5008699357- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Blood transfusion and management
- Science and Education Research
- Education Pedagogy and Practices
- Education and Digital Technologies
- Abdominal Trauma and Injuries
- Blood donation and transfusion practices
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Maternal and fetal healthcare
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Evasion and Academic Success Factors
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Enhanced Recovery After Surgery
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Complement system in diseases
- Environmental Sustainability and Education
- Hemoglobinopathies and Related Disorders
Ospedale Policlinico San Martino
2020-2024
Jisc
2024
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2023
Universidade do Oeste de Santa Catarina
2014-2021
University of the West
2021
Azienda Unità Sanitaria Locale Della Romagna
2019-2020
Ospedale “M. Bufalini” di Cesena
2007-2019
Azienda-Unita' Sanitaria Locale Di Cesena
2015
Ospedale Infermi di Rimini
2004-2007
City Hospital
2004
Hemorrhage is the principal cause of death in first few hours following severe injury. Coagulopathy a frequent complication critical bleeding. A network Italian trauma centers recently developed protocol to prevent and treat trauma-induced coagulopathy. pre-post cohort multicenter study was conducted assess impact early coagulation support (ECS) on blood products consumption, mortality treatment costs.We prospectively collected data from all severely injured patients (Injury Severity Score...
Beta thalassemia (β-thalassemia) is part of a group inherited hemoglobinopathies caused by mutation in the beta globin gene, leading to minimal functional hemoglobin and resulting damaged red blood cells anemia. β-Thalassemia most common Mediterranean region, South-East Asia, Indian subcontinent, Middle East. Many these regions include low- middle-income countries where there are significant unmet needs adequate care management thalassemia. Patients with transfusion-dependent β-thalassemia,...
Summary We evaluated the additional benefit of Technetium 99 ‐sestamibi (99mTc‐MIBI) scanning in comparison with standard X‐ray techniques for multiple myeloma patients either at diagnosis or during follow‐up. Between February 2001 and January 2005, 397 whole body scans were acquired. On 229 performed diagnosis, 146 (64%) positive 81 cases have discordant results. The sensitivity 99mTc‐MIBI 77% 45% respectively. As a result 99mTc‐MIBI, 40% asymptomatic up‐staged. positivity correlated...
Postpartum hemorrhage (PPH) is one of the most frequent causes mortality and morbidity in obstetric population globally, causing about a quarter maternal deaths yearly, leading cause death worldwide. The management PPH remains topic great debate, even view new diagnostic therapeutic possibilities recent years, for which, however, body evidence available thus far still scarce, as standard values are lacking. protocol hereby presented was developed after literature review during several...
Patient blood management (PBM) is defined as the timely application of evidence-based medical and surgical concepts designed to maintain a patient’s hemoglobin concentration, optimize hemostasis, minimize loss in an effort improve outcomes. PBM able reduce mortality up 68%, reoperation 43%, readmission composite morbidity 41%, infection rate 80%, average length stay by 16%–33%, transfusion from 10% 95%, costs 84% after major surgery. It should be noticed, however, that process implementation...
Since 2012, in line with the World Health Organization (WHO) resolution WHA63.12 of 05/21/2010, Italian National Blood Center has been promoting patient blood management (PBM). In order to verify level PBM implementation nationwide, we submitted a survey all healthcare providers.
Adherence to optimal practices in the preparation and issuance of pediatric blood components can significantly influence patient care outcomes. This study aims examine banking procedures across prominent Italian children's hospitals, with goal identifying both consistent potentially divergent standards within this field.
In recent years, a strong focus has been put on the need to assure early coagulation support in order prevent and treat coagulopathy patients with severe trauma, improve survival.Aggressive plasma administration high plasma/ red blood cells ratio is increasingly used worldwide.However, transfusion associated increased risks of multiple organ dysfunction syndrome (MODS), adult respiratory distress (ARDS) infection, which may prolong hospital stay for artificial ventilation.Moreover, majority...
Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% CLL clones utilize quasi-identical cell receptors, defined as stereotyped BCR. CLL-like stereotyped-IG rearrangements are present in normal a part public IG repertoire. In this study, we collected details on representation and features IGH repertoire B-cell subpopulations purified from peripheral blood nine healthy donors. The were also...
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening microangiopathy caused by severe ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) deficiency, recurring in 30–50% of patients. The common human leukocyte antigen (HLA) variant rs6903608 was found to be associated prevalent iTTP, but whether this disease relapse unknown. To estimate the impact on iTTP onset relapse, we performed case-control cohort study 161 Italian patients...
Natural Killer cells (NKs) represent the innate counterpart of TCRαβ lymphocytes and are characterized by a high anti-tumor an anti-viral cytotoxic activity. Recently, it has been demonstrated that NKs can express PD-1 as additional inhibitory receptor. Specifically, was identified on subpopulation terminally differentiated from healthy adults with previous HCMV infection. So far is unknown whether appears during NK-cell development this process directly or indirectly related to In study, we...
Background Cisplatin-containing regimens represent the gold standard in treatment of advanced non-small cell lung cancer, but carboplatin is often preferred for its better toxic profile when palliation aim treatment. The synergistic effect and tolerability carboplatin-gemcitabine combination are well known. In this phase II trial, we evaluated activity safety a schedule with gemcitabine, defined our previous I trial. Methods Thirty-seven patients measurable stage IV cancer were treated...
Worldwide iron anemia is a common disorder with significant economic burden on health-care systems. Red blood cell transfusion the mainstay to correct in surgical settings, but it also an overused procedure and recent data support its possible role worsening patient outcomes. Patient Blood Management (PBM) multidisciplinary approach optimize hemostasis, manage anemia, minimize iatrogenic loss, improve tolerance anemia. The present paper aims provide "bundles" approach, based several...
Immune checkpoint inhibitors (CI) have demonstrated clinical activity in Hodgkin Lymphoma (HL) patients relapsing after autologous stem cell transplantation (ASCT), although only 20% complete response (CR) rate was observed. The efficacy of CI is strictly related to the host immune competence, which impaired heavily pre-treated HL patients. Here, we aimed enhance early post-ASCT (nivolumab) administration with infusion lymphocytes (ALI). Twelve relapse/refractory (R/R) (median age 28.5...