A5012580815- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Reproductive System and Pregnancy
- Hematopoietic Stem Cell Transplantation
- Chemokine receptors and signaling
- Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Mathematical Biology Tumor Growth
- Mycobacterium research and diagnosis
- PARP inhibition in cancer therapy
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
University of Genoa
2015-2024
Ospedale Policlinico San Martino
2024
University of Gothenburg
2019-2024
Sahlgrenska University Hospital
2019-2023
German BioImaging – Gesellschaft für Mikroskopie und Bildanalyse
2020
In this study the phenotype and function of tumor-associated NK cells from peritoneal fluids a selected cohort patients with seropapillary ovarian carcinoma were analyzed. > 50% these patients, expression activating receptor NKp30 in was substantially reduced as compared to autologous peripheral blood (PB) cells. The impaired associated presence one its cellular ligands (B7-H6), which detectable surface/cytosolic molecule tumor soluble fluid. expressing NKp30low displayed an interferon-gamma...
Polymorphonuclear neutrophils (PMN) are potent inflammatory effector cells essential to host defense, but at the same time they may cause significant tissue damage. Thus, timely induction of neutrophil apoptosis is crucial avoid damage and induce resolution inflammation. NK have been reported influence innate adaptive immune responses by multiple mechanisms including cytotoxicity against other cells. In this study, we analyzed effect interaction between neutrophils. Coculture experiments...
Under physiological conditions, PD-1/PD-L1 interactions regulate unwanted over-reactions of immune cells and contribute to maintain peripheral tolerance. However, in tumor microenvironment, this interaction may greatly compromise the immune-mediated anti-tumor activity. PD-1+ NK have been detected high percentage blood ascitic fluid ovarian carcinoma patients. To acquire information on PD-1 expression physiology human cells, we analyzed whether mRNA protein are present resting, surface...
Abstract Polymorphonuclear neutrophils (PMNs) are innate effector cells with pivotal roles in pathogen recognition, phagocytosis, and eradication. However, their role the development of subsequent immune responses is incompletely understood. This study aimed to identify mechanisms relevance cross talk between human NK its potential promoting adaptive immunity. TLR-stimulated PMNs were found release soluble mediators attract activate vitro. PMN-conditioned displayed enhanced cytotoxicity...
Natural killer cells are cytotoxic innate lymphoid that play an important role for early host defenses against infectious pathogens and surveillance tumor. In humans, NK may be divided in various subsets on the basis of relative CD56 expression low-affinity FcγRIIIA CD16. particular, two main cell represented by CD56bright/CD16-/dull CD56dull/CD16bright cells. Experimental evidences indicate CD56bright CD56dull represent different maturative stages developmental pathway. We identified...
Immune checkpoint blockade therapy has changed prognoses for many melanoma patients. However, immune responses that correlate with clinical progression of the disease are still poorly understood. To identify correlating evolution, we analyzed serum cytokines as well circulating NK and T-cell subpopulations from The patients' profiles suggested leads to changes in peripheral blood subsets. Stage IV was characterized by an increased frequency CCR7+CD56bright cells high concentrations CCR7...
Natural killer (NK) cell immunotherapy has gained attention as a promising strategy for treatment of various malignancies. In this study, we used genome-wide CRISPR screen to identify genes that provide protection or susceptibility NK cytotoxicity. The confirmed the role several in regulation, such involved interferon-γ signaling and antigen presentation, well encoding receptor ligands B7-H6 CD58. Notably, gene TMEM30A , CDC50A–beta-subunit flippase shuttling phospholipids plasma membrane,...