A5043058160- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Viral-associated cancers and disorders
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Reproductive System and Pregnancy
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Intraperitoneal and Appendiceal Malignancies
- Salivary Gland Tumors Diagnosis and Treatment
- Immune cells in cancer
- MicroRNA in disease regulation
- Eosinophilic Esophagitis
- Lung Cancer Treatments and Mutations
University of Genoa
2016-2025
Innate Pharma (France)
2020
Natural killer cells are cytotoxic innate lymphoid that play an important role for early host defenses against infectious pathogens and surveillance tumor. In humans, NK may be divided in various subsets on the basis of relative CD56 expression low-affinity FcγRIIIA CD16. particular, two main cell represented by CD56bright/CD16-/dull CD56dull/CD16bright cells. Experimental evidences indicate CD56bright CD56dull represent different maturative stages developmental pathway. We identified...
Endometrial carcinoma (EC) is the most common gynecological malignancy, with increasing incidence linked to rising risk factors. This retrospective observational study investigates role of Androgen Receptor (AR) in EC aggressiveness, its correlation other prognostic markers, and potential therapeutic implications. A total 143 cases treated hysterectomy were analyzed for AR expression association clinicopathological molecular including estrogen receptor (ER), progesterone (PR), Ki-67, p53,...
Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of oral malignancies and has a 5-year mortality rate close to 50%. A consistent part (70%) all cancers is diagnosed at an advanced stage since available screening techniques are ineffective. Therefore, it would be urgent improve them. The diagnostic gold standard tissue biopsy with histological immunohistochemical assessment. This method presents some limitations. Biopsy invasive the histopathological evaluation...
Peritoneal carcinomatosis (PC) is a rare disease defined as diffused implantation of neoplastic cells in the peritoneal cavity. This clinical picture occurs during evolution tumors, and it main cause morbidity mortality patients affected by these pathologies, though cytoreductive surgery with heated intra-peritoneal chemotherapy (CRS/HIPEC) yielding promising results. In present study, we evaluated whether tumor microenvironment low-grade high-grade PC could affect phenotypic functional...
we evaluated the concordance between immunohistochemical p53 staining and TP53 mutations in a series of HGSOC. Moreover, searched for prognostic differences overexpression null expression groups.patients affected by HGSOC were included. For each case molecular assay (Sanger sequencing) performed. Kaplan-Meier survival analyses undertaken to determine whether type mutation, or pattern influenced overall (OS) progression free (PFS).34 considered. All cases with (n=16) showed (n=9 nonsense, n=4...
We report a case of inflammatory colitis after SARS-CoV-2 infection in patient with no additional co-morbidity who died within three weeks hospitalization. As it is becoming increasingly clear that can cause immunological alterations, we investigated the expression inhibitory checkpoint PD-1 and its ligand PD-L1 to explore potential role this axis break self-tolerance. The presence virus colon tissue was demonstrated by qRT-PCR immunohistochemical localization nucleocapsid protein....
Natural Killer cells (NKs) represent the innate counterpart of TCRαβ lymphocytes and are characterized by a high anti-tumor an anti-viral cytotoxic activity. Recently, it has been demonstrated that NKs can express PD-1 as additional inhibitory receptor. Specifically, was identified on subpopulation terminally differentiated from healthy adults with previous HCMV infection. So far is unknown whether appears during NK-cell development this process directly or indirectly related to In study, we...
Immune checkpoint inhibitors (CI) have demonstrated clinical activity in Hodgkin Lymphoma (HL) patients relapsing after autologous stem cell transplantation (ASCT), although only 20% complete response (CR) rate was observed. The efficacy of CI is strictly related to the host immune competence, which impaired heavily pre-treated HL patients. Here, we aimed enhance early post-ASCT (nivolumab) administration with infusion lymphocytes (ALI). Twelve relapse/refractory (R/R) (median age 28.5...
Oral leukoplakia is classified among oral potentially malignant disorders (OPMDs) by the World Health Organization (WHO). The visual examination (VOE) most used method for identifying lesions in their early stages. Given that diagnosis of cancer often late, there an urgent need detection and lesions. Surgical biopsy represents gold standard as a diagnostic method, but because it invasive, cannot be repeated periodic checks. We report case lesion on buccal mucosa 65-year-old male patient with...
Despite recent advances in ovarian cancer (OC) treatment, including the introduction of bevacizumab and PARP-inhibitors, OC remains a lethal disease. Other therapeutic options are being explored, such as immunotherapy (IT), which has been proved effective many solid tumors. Findings about tumor-infiltrating cytotoxic regulatory T cells, together with expression PD-1 on immune cells PD-L1 tumor gave rationale for an attempt to use IT also OC. We treated two patients avelumab, anti-PD-L1...
Background: PD-1 is an immunological checkpoint that limits immune responses by delivering potent inhibitory signals to T cells upon interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing escape mechanisms (1). Therapeutic blockade has been shown mediate tumor eradication impressive clinical results. Little known the expression/function of human NK (2). Objective: To clarify whether may express and analyze their phenotypic/functional features. Methods:...