A5015758272- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- T-cell and B-cell Immunology
- Lung Cancer Research Studies
- RNA modifications and cancer
- Light effects on plants
- Acute Myeloid Leukemia Research
- Phagocytosis and Immune Regulation
- Cancer therapeutics and mechanisms
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
University of Gothenburg
2023-2024
Sahlgrenska University Hospital
2023
Institute of Biomedical Science
2023
Anaplastic lymphoma kinase (ALK) fusion variants in Non-Small Cell Lung Cancer (NSCLC) consist of numerous dimerizing partners. Retrospective investigations suggest that treatment benefit response to ALK tyrosine inhibitors (TKIs) differs dependent on the variant present patient tumor. Therefore, understanding oncogenic signaling networks driven by different is important. To do this, we developed controlled inducible cell models expressing either Echinoderm Microtubule Associated Protein...
Natural killer (NK) cell immunotherapy has gained attention as a promising strategy for treatment of various malignancies. In this study, we used genome-wide CRISPR screen to identify genes that provide protection or susceptibility NK cytotoxicity. The confirmed the role several in regulation, such involved interferon-γ signaling and antigen presentation, well encoding receptor ligands B7-H6 CD58. Notably, gene TMEM30A , CDC50A–beta-subunit flippase shuttling phospholipids plasma membrane,...
An all-photonic method is described, in which (i) the release of an active kinase inhibitor controlled externally with light; and (ii) fluorescence employed to report both binding its corresponding target.
The natural killer (NK) complex (NKC) harbors multiple genes such as KLRC1 (encoding NKG2A) and KLRK1 NKG2D) that are central to regulation of NK cell function. We aimed at determining what extent NKC haplotypes impact on repertoire function, whether gene variants outcome IL-2-based immunotherapy in acute myeloid leukemia (AML).Genotype status NKG2D rs1049174 NKG2A rs1983526 was determined using the TaqMan-Allelic discrimination approach. To dissect single nucloetide polymorphim (SNP) we...
Abstract Anaplastic lymphoma kinase (ALK) fusion variants in non-small-cell-lung cancer (NSCLC) consist of numerous dimerising partners, with the most common being EML4. Clinical data suggests that degree treatment benefit response to ALK tyrosine inhibitors (TKIs) differs among variant present patient tumor. Therefore, a better understanding oncogenic signaling networks driven by different ALK-fusion is important. Here, we developed highly controlled doxycycline-inducible cell models...