A5025259131- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
Sahlgrenska University Hospital
2023
University of Gothenburg
2023
The natural killer (NK) complex (NKC) harbors multiple genes such as KLRC1 (encoding NKG2A) and KLRK1 NKG2D) that are central to regulation of NK cell function. We aimed at determining what extent NKC haplotypes impact on repertoire function, whether gene variants outcome IL-2-based immunotherapy in acute myeloid leukemia (AML).Genotype status NKG2D rs1049174 NKG2A rs1983526 was determined using the TaqMan-Allelic discrimination approach. To dissect single nucloetide polymorphim (SNP) we...
HLA-B alleles are associated with outcomes in various pathologies, including autoimmune diseases and malignancies. The encoded proteins pivotal antigen presentation to cytotoxic T cells, some variants containing a Bw4 motif also serve as ligands the killer immunoglobulin-like receptors (KIR) 3DL1/S1 of NK cells. We investigated potential impact genotypes on efficacy immunotherapy for relapse prevention acute myeloid leukemia (AML). Seventy-eight non-transplanted AML patients receiving...
Abstract HLA-B proteins interact with key immune receptors on both T and NK cells, variants of the encoding gene are associated outcomes in various pathologies, including autoimmune diseases malignancies. is pivotal antigen presentation to cytotoxic some containing a Bw4 motif also serve as ligands killer immunoglobulin-like (KIR) 3DL1/S1 cells. We investigated potential impact genotypes efficiency immunotherapy for relapse prevention acute myeloid leukemia (AML). Seventy-nine...