A5015713484- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- PARP inhibition in cancer therapy
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease and Transplantation
- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Enhanced Recovery After Surgery
- Hip and Femur Fractures
- Patient-Provider Communication in Healthcare
- Dental Research and COVID-19
- Ocular Surface and Contact Lens
- Diversity and Career in Medicine
- Nephrotoxicity and Medicinal Plants
- Pelvic and Acetabular Injuries
Jisc
2024
Ospedale Policlinico San Martino
2024
Ospedale di Santo Spirito
2016-2023
University of Bologna
2023
Collaborative Group (United States)
2021
Ospedali Riuniti Umberto I
2008-2013
Fondazione Piemontese per la Ricerca sul Cancro Onlus
2003-2006
OBJECTIVES To examine the outcomes of a hepatectomy for intrahepatic cholangiocarcinoma (IHC) and to clarify prognostic impact lymphadenectomy surgical margin. Large series patients who were surgically treated IHC are scarce. Thus, factors long-term survival after resection remain uncertain. DESIGN Prospective study IHC. Clinicopathologic, operative, data analyzed. SETTING Prospectively collected all consecutive with pathologically confirmed had undergone liver curative intent at 1 16...
To assess the survival benefit of additional resection an intraoperative positive proximal bile duct margin (BD(Marg)) in patients undergoing hepatectomy for hilar cholangiocarcinoma (HCCA).Intraoperative evidence invasive cancer at is associated with a dismal irrespective whether final negative achieved resection.Clinicopathologic, operative, and data consecutive undergone curative intent (n = 75) HCC (1989-2010) were analyzed.Frozen-section examination revealed 19 67 patients. After...
Abstract Background Laparoscopic liver surgery must reproduce open surgical steps. Intraoperative ultrasonography (IOUS) is mandatory, but reliability of laparoscopic IOUS has been poorly evaluated. The aim this study was to compare versus in staging tumours. Methods All patients scheduled for resection between September 2009 and March 2011 were considered. Inclusion criteria primary metastatic Exclusion were: hilar/gallbladder cholangiocarcinoma, ten or more lesions, repeat resection,...
To determine which method of liver volumetry is more accurate in predicting a safe resection.Before major or extended hepatectomy, assessment the future remnant (FLR) crucial to reduce risk postoperative hepatic insufficiency. The FLR volume usually expressed as ratio nontumorous total (TLV), can be measured directly by computed tomography (mTLV) estimated (eTLV) on basis correlation existing with body surface area. date, these 2 methods have never been compared.All consecutive, noncirrhotic...
Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted surgical community. Recommendations have been published to manage patients needing surgery during pandemic. This survey, under aegis Italian Society Endoscopic Surgery, aims analyze how surgeons changed their practice Methods authors designed an online survey that was circulated for completion departments general registered in Ministry Health database December 2020. Questions were...
Abstract Despite negative results of clinical trials conducted on the overall population patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window opportunity for subpopulation cancer. An estimated 7% to 12% cancers exhibit mutational signature associated homologous recombination (HR) failure, suggesting that these could potentially benefit from PARPis. To analyze responsiveness cancer PARPi, we exploited gastroesophageal adenocarcinoma (GEA)...
Patient blood management (PBM) is defined as the timely application of evidence-based medical and surgical concepts designed to maintain a patient’s hemoglobin concentration, optimize hemostasis, minimize loss in an effort improve outcomes. PBM able reduce mortality up 68%, reoperation 43%, readmission composite morbidity 41%, infection rate 80%, average length stay by 16%–33%, transfusion from 10% 95%, costs 84% after major surgery. It should be noticed, however, that process implementation...
When treating potentially resectable pancreatic adenocarcinoma, therapeutic decisions are left to the sensibility of clinicians who, faced with a decision that post hoc can be proven wrong, may feel sense regret they want avoid. A regret-based model was applied evaluate attitudes toward neoadjuvant therapy versus upfront surgery for adenocarcinoma.Three clinical scenarios describing high-, intermediate-, and low-risk disease-specific mortality after were presented 60 respondents (20...
Most T2 gallbladder cancers are diagnosed at final pathology after cholecystectomy. Reoperations including liver resection and regional lymph node dissection needed to achieve better long-term results. The aim of this study is evaluate results reresections prior non-curative surgery for carcinomas.Retrospective from January 1985 July 2001. Twelve out 14 pT2 were found postoperatively. All but one underwent reresection: these 11 patients the basis our series.The in-hospital mortality rate was...
Background: The mineral phases regulated as “asbestos” have a well-known role in disease development the respiratory tract (e.g. mesothelioma, pulmonary carcinoma, asbestosis), but it is not clear their cancer other body sites, colon-rectum tract. Materials and Methods: In this work, seven colon tissues (healthy neoplastic portions an area “bridge” between them) from patients affected by adenocarcinoma – living highly asbestos-polluted - been digested inorganic residual components collected...
The aim of this work was to inspect the presence asbestos fibers in colon tissue from a patient, with history indirect exposure and affected by cancer, who underwent surgery. Variable pressure scanning electron microscopy, coupled energy dispersive spectroscopy (VP-SEM/EDS), used for identification inorganic their morphological—chemical characterization. Fresh samples both, healthy area close neoplasia neoplastic regions, were separately digested eliminate biological matrix. precipitate...
<div>Abstract<p>Despite negative results of clinical trials conducted on the overall population patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window opportunity for subpopulation cancer. An estimated 7% to 12% cancers exhibit mutational signature associated homologous recombination (HR) failure, suggesting that these could potentially benefit from PARPis. To analyze responsiveness cancer PARPi, we exploited gastroesophageal...