A5059164256- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- COVID-19 Impact on Reproduction
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- COVID-19 and healthcare impacts
- Preterm Birth and Chorioamnionitis
- Pluripotent Stem Cells Research
- Blood Coagulation and Thrombosis Mechanisms
- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Hemophilia Treatment and Research
- Pregnancy and Medication Impact
- Surgical Sutures and Adhesives
- Uterine Myomas and Treatments
- Ultrasound in Clinical Applications
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Platelet Disorders and Treatments
- Zebrafish Biomedical Research Applications
- Hematopoietic Stem Cell Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
Duke Medical Center
2013-2025
Duke University
2014-2024
Durham Technical Community College
2024
University Hospital of Geneva
2023
Duke University Hospital
2016-2023
Harvard University
2022
Boston Children's Hospital
2022
Fundación Valle del Lili
2022
University of North Carolina at Chapel Hill
2006-2007
Infections at the maternal-fetal interface can directly harm fetus and induce complications that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived placental trophoblasts maternal decidua must provide antimicrobial defenses this critical without compromising its integrity. Here, we developed matched trophoblast (TO) organoids (DO) from human placentas to define relative contributions of these cells antiviral interface. We demonstrate TO DO basally secrete...
Placenta accreta spectrum (PAS) is one of the most dangerous conditions in pregnancy and increasing frequency. The risk life-threatening bleeding present throughout but particularly high at time delivery. Although exact cause unknown, result clear: Severe PAS distorts uterus surrounding anatomy transforms pelvis into an extremely high-flow vascular state. Screening for factors assessing placental location by antenatal ultrasonography are essential timely diagnosis. Further evaluation...
Background Postcesarean wound morbidity is a costly complication of cesarean delivery for which preventative strategies remain understudied. Objective We compared surgical site occurrences (SSOs) in patients receiving closed-incision negative-pressure therapy (ciNPT) or standard-of-care (SOC) dressing. Study Design A single-center randomized controlled trial ciNPT (5-7 days) to SOC dressing (1-2 obese women (body mass index [BMI] ≥ 35), undergoing between 2012 and 2014. Participants were 1:1...
Abstract Between birth and adulthood, the human gut is colonized by a complex microbial community. Despite established links between infant microbiome health, knowledge limited for how complementary feeding influences colonization. Using FoodSeq, an objective DNA-based dietary assessment technique, we analyzed 1,036 fecal samples from 729 children aged 0-3 years across countries in North America, Central Africa, Asia. We detected wide diversity of 199 unique plant food sequences, which only...
Our recent gene expression profiling analyses demonstrated that Wnt2 is highly expressed in Flk1(+) cells, which serve as common progenitors of endothelial blood and mural cells. In this report, we characterize the role mesoderm development during embryonic stem (ES) cell differentiation by creating ES lines was deleted. Wnt2(-/-) embryoid bodies (EBs) generated increased numbers cells blast colony-forming compared with wild-type EBs, had higher Flk1 at comparable stages differentiation....
Immunodysregulation, Polyendocrinopathy, Enteropathy, X‐linked (IPEX) syndrome is a rare, recessive disease that affects regulatory T cells (Tregs) resulting in diarrhea, enteropathy, eczema, and insulin‐dependent diabetes mellitus. IPEX caused by pathogenic alterations FOXP3 located at Xp11.23. encodes transcription factor interacts with several partners, including NFAT NF‐κB, necessary for the proper cellular differentiation of Tregs. Although variable, vast majority patients have onset...
Patients with preeclampsia are at high risk for long-term cardiovascular events, yet the short-term, acute complications that follow understudied. The objective of this study was to compare maternal morbidity events after delivery among patients a diagnosis versus those without diagnosis.
Objective This study compares the number of units red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and selective use either immediate delayed hysterectomy. Study Design is retrospective deliveries conducted at tertiary care hospital from 2001 to 2018 pathology-confirmed PAS. Those previable pregnancies microinvasive histology were excluded. To...
Abnormal placentation can be associated with significant blood loss and massive transfusions. Caring for parturients abnormal who refuse transfusion is very challenging. We present a 35-year-old, gravida 3, para 1, Jehovah's Witness at 35 weeks of gestation placenta percreta, underwent cesarean delivery delayed hysterectomy. A multidisciplinary team developed plan, including the use perioperative erythropoietin IV iron dextran, intraoperative acute normovolemic hemodilution, cell salvage,...
Abstract Hematopoietic stem cells (HSCs) have enormous potential for use in transplantation and gene therapy. However, the frequency of repopulating HSCs is often very low; thus, highly effective techniques cell enrichment maintenance are required to obtain sufficient numbers therapeutic studies HSC physiology. Common methods antibodies recognizing surface marker antigens. Because known alter physiology other types, we investigated effect such strategies on lineage commitment HSCs. We sorted...
Surgical training experience in obstetrics-gynecology (OB-GYN) residency and fellowship training, particularly open abdominal surgeries has declined over the last 2 decades. This is due, part, due to a universal trend toward non-invasive treatments for gynecologic conditions once treated surgically. Management of placenta accreta spectrum (PAS) often requires complex surgical skills, including, but not limited highly hysterectomy. The decline case numbers fallen as incidence PAS risen, which...
Abstract Infections at the maternal-fetal interface can directly harm fetus and induce complications that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived placental trophoblasts maternal decidua must provide antimicrobial defenses this critical without compromising its integrity. Here, we developed matched trophoblast organoids from human placentas to define relative contributions of these cells antiviral interface. We demonstrate basally secrete distinct...
Portal hypertension in pregnancy is associated with elevated risk of variceal hemorrhage. Ectopic varices, those located outside the esophagus or stomach, are rare but have a high maternal morbidity mortality.A 31-year-old woman, gravida 2 para 0010, cirrhosis and portal was found to abdominal wall ectopic varices on third-trimester obstetric ultrasonography. Computed tomography angiography confirmed these findings. Given concern for catastrophic hemorrhage during delivery, she underwent...
We describe outcomes of patients with suspected placenta percreta treated placental uterine artery embolization (P-UAE) followed by delayed hysterectomy. This is a prospective case series subjects from 2005 to 2018 who underwent P-UAE at the time cesarean delivery Both scheduled and unscheduled surgical cases were included. Maternal characteristics, approaches, intra- postoperative abstracted medical records. In total, twenty-two Median (interquartile range, IQR) gestational age was 34.6...
To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury healing.Elective surgery is an opportunity understand both the systemic focal responses accompanying well-characterized human body. The overarching goal this ongoing project define stereotypical surgical injury, translational purpose identifying targetable pathways involved in healing resilience, variations indicative aberrant...