A5085763279- Neonatal and fetal brain pathology
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 Impact on Reproduction
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Reproductive Biology and Fertility
- Cancer Risks and Factors
- Advanced MRI Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Domain Adaptation and Few-Shot Learning
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Prenatal Screening and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Cancer survivorship and care
- Child and Adolescent Psychosocial and Emotional Development
- Maternal and Perinatal Health Interventions
- Family Support in Illness
- Endometrial and Cervical Cancer Treatments
- Autopsy Techniques and Outcomes
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
Children's National
2018-2023
National Hospital
2022
National Hospital for Neurology and Neurosurgery
2021
University College London
2021
Georgetown University
2020
Memorial Sloan Kettering Cancer Center
2014-2018
Kettering University
2015
<h3>Importance</h3> Prenatal maternal psychological distress is associated with disturbances in fetal brain development. However, the association between altered development, prenatal distress, and long-term neurodevelopmental outcomes unknown. <h3>Objective</h3> To determine of development using 3-dimensional magnetic resonance imaging (MRI) volumes, cortical folding, metabolites setting infant 18-month neurodevelopment. <h3>Design, Setting, Participants</h3> Healthy mother-infant dyads...
<h3>Importance</h3> Maternal psychological distress during pregnancy is associated with adverse obstetric outcomes and neuropsychiatric deficits in children. Currently unavailable vivo interrogation of fetal brain function could provide critical insights into the onset timing altered neurodevelopmental trajectories. <h3>Objective</h3> To investigate association between prenatal maternal stress, anxiety, depression resting state functional connectivity. <h3>Design, Setting, Participants</h3>...
<h3>Importance</h3> Children raised in settings with lower parental socioeconomic status are at increased risk for neuropsychological disorders. However, to date, the association between and fetal brain development remains poorly understood. <h3>Objective</h3> To determine vivo growth cerebral cortical using advanced, 3-dimensional magnetic resonance imaging. <h3>Design, Setting, Participants</h3> This cohort study of enrolled 144 healthy pregnant women from 2 low-risk community obstetrical...
Elevated maternal psychological distress during pregnancy is linked to adverse outcomes in offspring. The potential effects of intensified levels the COVID-19 pandemic on developing fetal brain are currently unknown.
<h3>BACKGROUND AND PURPOSE:</h3> MR imaging provides critical information about fetal brain growth and development. Currently, morphologic analysis primarily relies on manual segmentation, which is time-intensive has limited repeatability. This work aimed to develop a deep learning–based automatic segmentation method that improved accuracy robustness compared with atlas-based methods. <h3>MATERIALS METHODS:</h3> A total of 106 studies were acquired prospectively from fetuses between 23 39...
Abstract Recent advances in brain imaging have enabled non-invasive vivo assessment of the fetal brain. Characterizing development healthy fetuses provides baseline measures for identifying deviations function high-risk clinical groups. We examined 110 resting state MRI data sets from at 19 to 40 weeks’ gestation. Using graph-theoretic techniques, we characterized global organizational features functional connectome and their prenatal trajectories. Topological related network integration...
Sex-based differences in brain structure and function are observable throughout development thought to contribute behavior, cognition, the presentation of neurodevelopmental disorders. Using multiple support vector machine (SVM) models as a data-driven approach assess sex differences, we sought identify regions exhibiting sex-dependent functional connectivity determine whether they were robust sufficiently reliable classify even prior birth. To accomplish this, used sample 110 human fetal...
Background Due to random motion of fetuses and maternal respirations, image quality fetal brain MRIs varies considerably. To address this issue, visual inspection the images is performed during acquisition phase after 3D‐reconstruction, are re‐acquired if they deemed be insufficient quality. However, process time‐consuming subjective. Multi‐instance (MI) deep learning methods (DLMs) may perform task automatically. Purpose propose an MI count‐based DLM (MI‐CB‐DLM), vote‐based (MI‐VB‐DLM),...
Proton magnetic resonance spectroscopy (1H-MRS) of the fetal brain can be used to study emerging metabolite profiles in developing brain. Identifying early deviations metabolic high-risk fetuses may offer important adjunct clinical information improve surveillance and management during pregnancy.To investigate normative trajectory metabolites second half gestation, determine impact using different Cramer-Rao Lower Bounds (CRLB) threshold on measurements spectroscopy.We prospectively enrolled...
Abstract The subplate is a transient brain structure which plays key role in the maturation of cerebral cortex. Altered growth and cortical development have been suggested fetuses with complex congenital heart disease (CHD) third trimester. However, at an earlier gestation, putative altered CHD poorly understood. This study aims to examine (i.e., volume thickness) its relationship sulcal compared healthy by using 3D reconstructed fetal magnetic resonance imaging. We studied 260 fetuses,...
The Coronavirus Disease 2019 (COVID-19) pandemic has been accompanied by increased prenatal maternal distress (PMD). PMD is associated with adverse pregnancy outcomes which may be mediated the placenta. However, potential impact of on in vivo placental development remains unknown. To examine and structural using advanced magnetic resonance imaging (MRI), acquired anatomic images placenta from 63 pregnant women without known COVID-19 exposure during 165 pre-pandemic controls. Measures...
Purpose Quantitative susceptibility mapping (QSM) is an emerging tool for the precise characterization of human tissue, including regional oxygenation. A critical function placenta oxygen transfer to developing fetus, which remains difficult study in utero. The purpose this investigate feasibility performing QSM Methods In healthy pregnant women, 3D gradient echo data were acquired with prospective respiratory gating at 1.5 Tesla and 3 Tesla. brief period (6‐7 min) maternal hyperoxia was...
Gamma-aminobutyric acid and glutamate system disruptions may underlie neonatal brain injury. However, in vivo investigations are challenged by the need for special 1H-MR spectroscopy sequences reliable measurement of neurotransmitters this population. We used J-edited (Mescher-Garwood point-resolved spectroscopy) to quantify regional gamma-aminobutyric concentrations during early postnatal period healthy neonates. prospectively enrolled neonates acquired Mescher-Garwood spectra on a 3T MR...
9522 Background: In prior studies, menses was used as a surrogate for fertility. But, anti-mullerian hormone (AMH) may be better ovarian reserve. The goal of this study is to delineate the extent damage from specific treatments by using AMH level and menstrual calendars determine if chemo-induced amenorrhea levels correlate. Here we report results largest longitudinal with pretreatment evaluation measure impact chemo on reserve in women BC. Methods: A multi-institutional IRB-approved...
To study the impact of COVID-19 pandemic on in vivo microstructural and functional placental development using intra-voxel incoherent motion (IVIM) blood oxygen level dependent (BOLD) MRI, respectively. This is prospective, observational pregnant women with singleton gestations during (May 2020-present), compared to pre-pandemic historical controls (July 2014-February 2020). Placental imaging was identical for cohorts: including T2W anatomic images, PGSE sequences IVIM [TE/TR=53.8/8000ms 9...
In this prospective, longitudinal study we are determining the impact of COVID-19 on maternal stress and anxiety in non-COVID exposed, healthy pregnant women, compared to a pre-pandemic cohort women. We enrolled women with singleton gestations complete series validated mental health questionnaires, namely Spielberger State-Trait Anxiety Inventory (SSAI, state anxiety, STAI trait anxiety) Perceived Stress Scale (PSS). Group differences were assessed using student t-test Fischer's exact test....
Prenatal maternal stress is associated with adverse offspring outcomes, which may be mediated by hormones. However, evidence supporting the association between and cortisol levels in high-risk pregnancies limited. This study aims to determine relationship self-reported mental distress salivary complicated foetal CHD compared healthy pregnancies.We recruited women pregnancies. Maternal saliva was collected 22 40 gestational weeks. Standardized questionnaires measuring stress, depression,...
To study the impact of prenatal maternal stress during COVID-19 pandemic on in-vivo fetal brain biochemical profiles using magnetic resonance spectroscopy (MRS). We prospectively enrolled low-risk healthy pregnant women without any complications pandemic. compared measured in fetuses before with studied noninvasive MRS. All participants completed standardized questionnaires Perceived Stress Scale (PSS) and Spielberger State Anxiety Inventory (STAI-S) were scanned a 1.5T GE MR scanner....
Background: Elevated maternal psychological distress during pregnancy is linked to adverse short- and long-term outcomes in the offspring. The potential deleterious effects of intensified levels COVID-19 pandemic on developing fetal brain are currently unknown. Methods: We prospectively enrolled 202 pregnant women: 65 with negative diagnoses who underwent 92 MRI scans, 137 pre-pandemic controls had 182 scans. Multi-plane, multi-phase single shot fast spin echo T2-weighted images were...