A5103163433- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Thyroid Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Salivary Gland Tumors Diagnosis and Treatment
- Family Support in Illness
- Thyroid and Parathyroid Surgery
- Tracheal and airway disorders
- Hip and Femur Fractures
- Hormonal Regulation and Hypertension
- Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- BRCA gene mutations in cancer
- Childhood Cancer Survivors' Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Nutrition and Health in Aging
- Frailty in Older Adults
- Radiation Dose and Imaging
- Hormonal and reproductive studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Oral health in cancer treatment
- Primary Care and Health Outcomes
- Esophageal Cancer Research and Treatment
- European Union Policy and Governance
McGill University
2013-2025
Royal Victoria Hospital
2016-2024
McGill University Health Centre
2018-2024
Royal Victoria Regional Health Centre
2019
Montreal Children's Hospital
2011
Southern University
2006
Texas A&M University
2006
Texas Tech University
2006
University of Florida
2006
Bellarmine University
1996
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has risen rapidly, because an epidemic human papillomavirus infection. optimal management early-stage OPSCC with surgery or radiation continues to be a clinical controversy. Long-term randomized data comparing these paradigms are lacking.We randomly assigned patients T1-T2, N0-2 (≤ 4 cm) radiotherapy (RT) (with chemotherapy if N1-2) versus transoral robotic plus neck dissection (TORS + ND) without adjuvant therapy). primary end...
The optimal approach for treatment deescalation in human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCCs) is unknown.To assess a primary radiotherapy (RT) vs transoral surgical (TOS) HPV-related OPSCC.This international, multicenter, open-label parallel-group phase 2 randomized clinical trial was conducted at 9 tertiary academic cancer centers Canada and Australia enrolled patients with T1-T2N0-2 p16-positive OPSCC between February 13, 2018, November 17, 2020....
Radiotherapy (RT) and transoral robotic surgery (TORS) are both curative-intent treatment options for oropharyngeal squamous cell carcinoma (OPSCC). Herein, we report the final outcomes of ORATOR trial comparing these modalities, 5 years after enrollment completion. We randomly assigned 68 patients with T1-2N0-2 OPSCC to RT (with chemotherapy if node-positive) versus TORS plus neck dissection (± adjuvant RT/chemoradiation). The primary end point was swallowing quality life (QOL) assessed MD...
Objectives (1) Determine 1‐year period prevalence of suicidal ideation, suicide attempt, and completed among patients newly diagnosed with a first occurrence head neck cancer (HNC). (2) Characterize stability trajectory ideation over the year following diagnosis. (3) Identify at risk ideation. Study Design Prospective longitudinal study follow‐up. Setting Three university‐affiliated outpatient departments otolaryngology–head surgery. Subjects Methods The comprised representative sample 223...
Abstract Background Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients HPV-negative disease. Treatment options for HPV+ OPC can involve either a primary radiotherapy (RT) approach (± concomitant chemotherapy) or surgical adjuvant radiation) transoral surgery (TOS). These two paradigms different spectrums of toxicity. The goals this study are to assess the OS...
Background: Although the current gold standard for diagnosing thyroid nodule malignancy is ultrasound-guided fine-needle aspiration (FNA) cytology, about 20-25% of cytological evaluations are considered indeterminate malignancy. This limitation has led to emergence next-generation sequencing panels, example, ThyroSeq v3 (TSv3), which recognize highly diagnostic genetic mutations common carcinomas in FNA samples and classify them as test-negative or test-positive, helping optimize treatment...
Head and neck cancer (HNC) treatments are known to significantly affect functionality appearance, leading an increased risk for body image disturbances. Yet, few longitudinal studies exist examine in these patients. Based on a conceptual model, the current study aimed determine, patients newly diagnosed with HNC: (1) prevalence, level, course of concerns; (2) correlates upon diagnosis (pre-treatment) (3) predictors immediate post-treatment (4) association between concerns levels anxiety,...
Abstract Objectives While patients with head and neck cancer (HNC) are known to experience higher levels of anxiety depression, they do not always use psychosocial oncology (PSO) services when available. This study aimed investigate barriers PSO service utilization in this patient population, the goal appropriately targeting outreach interventions. Methods A conceptual model based on Behavioral Model Health Services Use was tested 84 newly diagnosed a first occurrence HNC followed...
Patients 65 years or older are the most frequent users of operative resources and also vulnerable to postoperative adverse events (AEs). Frailty indices increasingly being used for preoperative risk stratification within head neck cancer surgery, but models lack a multifactorial basis cannot be directly applied clinical practice. A practical index is needed clinicians gauge factors preoperatively.To develop short-term major AEs patients undergoing surgery.Cohort analysis from multiple...
Abstract Background A paradigm shift has led to de‐escalation trials for the treatment of HPV‐positive oropharynx cancer (OPC). The objective this study was assess ability tumor volume reduction on imaging predict pathological response neoadjuvant chemotherapy in patients with OPC. Methods prospective observational 54 OPC enrolled a clinical trial followed by surgery performed. Patients underwent three cycles induction (cisplatin/docetaxel); prechemotherapy and postchemotherapy were...
Abstract Background Neoadjuvant chemotherapy followed by surgery (NAC + S), a paradigm based on systemic escalation coupled with surgery‐based de‐escalation, is under investigation for treatment of HPV‐associated oropharynx cancer (OPC). Methods Prospective cohort patients non‐metastatic, p16 positive OPC enrolled in clinical trial NAC S was compared to historic undergoing concurrent chemoradiation (CCRT) compare disease‐free survival (DFS). Results Fifty‐five were treated and 142 CCRT....
Abstract Background Molecular testing has been used for cytologically indeterminate thyroid nodules (Bethesda III and IV), where the risk of malignancy is 10–40%. However, to date, role molecular in suspicious or positive V VI) controversial. The aim this study was determine whether patients who had Bethesda VI optimal extent surgery performed more often than did not have performed. Methods A retrospective chart review 122 cases performed: 101 from McGill University teaching hospitals 21...
The COVID-19 pandemic placed considerable strain on the healthcare system, leading to re-allocation of resources and implementation new practice guidelines. objective this study is assess impact guideline modifications head neck cancer (HNC) care at two tertiary centers in Canada.A retrospective cohort was conducted. HNC patients seen before after onset (pre-pandemic: July 1st, 2019, February 29th, 2020; pandemic: March 2020, October 31st, 2020) were included. pre-pandemic cohorts compared...
To determine whether sentinel lymph node (SLN) biopsy can accurately predict central compartment metastasis in patients with differentiated thyroid carcinoma.Prospective clinical study.Academic tertiary care center.Ninety-eight (82 women and 16 men; mean age, 48.3 years) underwent a total thyroidectomy dissection.Peritumoral injection of methylene blue dye, 1%, followed by SLN biopsy.The final pathology report established the presence among SLNs nodes that did not stain (non-SLNs...
The aim of this study is to prospectively review the role sentinel lymph node (SLN) biopsy in management well differentiated thyroid carcinoma (WDTC), and determine efficacy intraoperative frozen section analysis at detecting SLN metastasis central compartment involvement.The protocol using 1% methylene blue was performed 300 patients undergoing thyroidectomy for WDTC. A limited pretracheal neck dissection (CCND) on all patients. Lymph nodes staining were considered as SLN's. Both permanent...
Abstract Objectives Human papillomavirus (HPV) has prompted a need to further investigate how this new biomarker changes the head and neck cancer (HNC) psychosocial landscape. This study aimed to: (a) characterize sociodemographic, psychological, social profiles of patients with HPV‐positive versus ‐negative squamous cell carcinoma neck; (b) identify HPV status contributes anxiety depression (primary outcome), quality life (QoL), sexuality needs. Methods We conducted prospective longitudinal...
(1) Background: Patients and survivors of head neck cancer (HNC) are at a high risk developing body image concerns. Despite the prevalence concerns in patients with HNC, there is lack longitudinal research exploring wide array its associated determinants. The current study examined determinants course dissatisfaction HNC. (2) Methods: participated Structured Clinical Interviews self-administered questionnaires four time-points: (T1) upon diagnosis, (T2) 3 months post-diagnosis, (T3) 6 (T4)...
Abstract Objective The primary purpose of this study was to identify predictors Major Depressive Disorder in head and neck cancer (HNC) patients the immediate post‐treatment period (ie, at 3 months post‐diagnosis), with a focus on previously unexamined historical contextual factors. Methods Prospective longitudinal 223 consecutive adults (72% participation) newly diagnosed first occurrence HNC, including validated psychometric measures, Structured Clinical Interviews for DSM Disorders,...