A5073311191- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Cancer survivorship and care
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Diagnosis and Treatment
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Clinical practice guidelines implementation
- Ear and Head Tumors
- Reconstructive Facial Surgery Techniques
- Lung Cancer Treatments and Mutations
- Oral health in cancer treatment
- Surgical Simulation and Training
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Nasal Surgery and Airway Studies
- Anesthesia and Pain Management
- Palliative Care and End-of-Life Issues
- Pain Management and Opioid Use
University of Calgary
2016-2025
Cancer Institute (WIA)
2022-2024
AstraZeneca (United Kingdom)
2024
New York University
2023
Foothills Medical Centre
2012-2022
Alberta Health Services
2011-2022
King Saud bin Abdulaziz University for Health Sciences
2021
Institute of Cancer Research
2017
Alberta Cancer Foundation
2013
Michigan Medicine
2009-2012
The spatial organization of the tumor microenvironment has a profound impact on biology and therapy response. Here, we perform an integrative single-cell transcriptomic analysis HPV-negative oral squamous cell carcinoma (OSCC) to comprehensively characterize malignant cells in core (TC) leading edge (LE) transcriptional architectures. We show that TC LE are characterized by unique profiles, neighboring cellular compositions, ligand-receptor interactions. demonstrate gene expression profile...
The optimal approach for treatment deescalation in human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCCs) is unknown.To assess a primary radiotherapy (RT) vs transoral surgical (TOS) HPV-related OPSCC.This international, multicenter, open-label parallel-group phase 2 randomized clinical trial was conducted at 9 tertiary academic cancer centers Canada and Australia enrolled patients with T1-T2N0-2 p16-positive OPSCC between February 13, 2018, November 17, 2020....
<h3>BACKGROUND AND PURPOSE:</h3> Head and neck cancer is common, understanding the prognosis an important part of patient management. In addition to Tumor, Node, Metastasis staging system, tumor biomarkers are becoming more useful in directing treatment. We assessed whether MR imaging texture analysis would correctly classify oropharyngeal squamous cell carcinoma according p53 status. <h3>MATERIALS METHODS:</h3> A cohort 16 patients with was prospectively evaluated by using standard...
Abstract Background Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients HPV-negative disease. Treatment options for HPV+ OPC can involve either a primary radiotherapy (RT) approach (± concomitant chemotherapy) or surgical adjuvant radiation) transoral surgery (TOS). These two paradigms different spectrums of toxicity. The goals this study are to assess the OS...
Oral cavity cancer often requires multidisciplinary management, subjecting patients to complex therapeutic trajectories. Prolonged treatment intervals in oral have been associated with poor oncological outcomes, but there has yet be a study investigating times Canada.
Abstract There are few prognostic biomarkers and targeted therapeutics currently in use for the clinical management of oral squamous cell carcinoma (OSCC) patient outcomes remain poor this disease. A majority mutations OSCC loss-of-function events tumour suppressor genes that refractory to conventional modes targeting. Interestingly, chromosomal segment 3q22-3q29 is amplified many epithelial cancers, including OSCC. We hypothesized some 468 located on might be drivers carcinogenesis could...
The objective of this study is to evaluate the cost-effectiveness a postoperative clinical care pathway for patients undergoing major head and neck oncologic surgery with microvascular reconstruction. This comparative trial prospective treatment group managed on historical prior implementation. Effectiveness outcomes evaluated were total hospital days, return OR, readmission ICU rate pulmonary complications. Costing perspective was from government payer. 118 included in study. All...
Importance The standard of care for patients with oral cavity squamous cell carcinoma (OCSCC) is generally primary surgical resection or without adjuvant therapy (AT), based on pathological factors. Identifying preoperative factors that are associated the receipt AT may enhance treatment planning. Objective To identify patient and tumor receiving AT, either radiation (RT) chemoradiation (CRT), in OCSCC. Design, Setting, Participants This cohort study, spanning January 2005 to December 2019...
Patients with head and neck cancer frequently present to academic tertiary referral centers imaging studies that have been performed interpreted elsewhere. At our institution, these outside undergo formal second opinion reporting by a fellowship-trained neuroradiologist expertise in imaging. The purpose of this study was determine the impact practice on staging patient management.Our institutional review board approved retrospective randomized original reports for 94 consecutive cases biopsy...
Pulmonary complications are common after major head and neck oncologic surgery with microsurgical reconstruction associated increased mortality morbidity. Clinical care pathways evidence-based tools that reduce unnecessary practice variation ultimately improve patient outcomes. In this study, the authors evaluate effectiveness of a comprehensive pathway on reducing postoperative pulmonary hospital length stay in patients undergoing carcinoma resection free flap reconstruction.Fifty-five...
Postoperative opioid use has been linked to the subsequent development of dependency. Multimodal analgesia (MMA) can reduce opioids in postoperative period, but MMA not well-studied after major head and neck surgery. Our goal is explore association between pain control patients undergoing We performed a retrospective study adult (age ≥ 18 years) primary cancer resection with free-flap reconstruction. All were treated using an established care pathway. The baseline group was January...
Background: The extent of initial surgical resection for low-risk papillary thyroid cancer (PTC) remains debatable. Since the 2015 American Thyroid Association (ATA) guidelines, several retrospective studies have reported that 40–60% patients initially treated with lobectomy would require a completion thyroidectomy (CTx) due to high-risk pathological features (HRFs). These are limited by variable preoperative stratification and inability quantify value intraoperative assessment. study...
Surgery with free flap reconstruction is a standard treatment for head and neck cancer (HNC). Because of the complexity HNC surgery, recovery can be challenging, complications are common. One foundations enhanced after surgery (ERAS) early postoperative mobilization. The ERAS guidelines recommend mobilization within 24 h. This based mainly on evidence from other surgical disciplines, extent to which h improves has not been explored. retrospective analysis included 445 patients Calgary Head...
Background Close margins influence treatment and outcome in patients with oral squamous cell carcinoma (OSCC). This study evaluates 187 cases of surgically treated OSCC regarding the impact close on recurrence-free survival (RFS) disease-specific (DSS). Methods Predictors worsened were identified using Kaplan-Meier analysis multivariate Cox regression analysis. Results Tumour size [HR:1.70(0.95–3.08)], nodal status [HR:2.15(1.00–4.64)], presence extracapsular spread (ECS)...
Thyroid nodules affect up to 65% of the population. Although fine needle aspirate (FNA) cytology is gold standard for diagnosis, 15-30% results are indeterminate. Molecular testing may aid in diagnosis and potentially reduce unnecessary surgery. However, these tests associated with significant costs. The objective this study was evaluate cost-effectiveness Afirma, a commercially available molecular test, cytologically indeterminate thyroid nodules.The base case solitary nodule no additional...
Dermal fat grafts are used to reconstruct facial contour defects but may undergo variable resorption. Application of autologous platelet adhesive improve outcomes. The primary objective was compare resorption dermal for parotidectomy defects, between patients receiving versus controls.This a double-blinded prospective cohort at tertiary care center. Volumetric analyses graft measured by MRI scans. Resorption determined comparing 1- and 6-month MRIs in each patient. Complications, Frey's...
Abstract Background The purpose of this study was to describe the relationship p16 and epidermal growth factor receptor (EGFR) expression with survival in surgically treated patients who had oropharyngeal or oral cavity squamous cell carcinoma (SCC). Methods Tissue from 36 SCC 49 between 1997 2001 imbedded immunostained using a tissue microarray. Results positive 57% 13% SCC, respectively. EGFR 60% 63% In associated improved disease‐specific (DSS), overall (OS), time recurrence (TTR) ( p...
ABSTRACT Background Oral cavity squamous cell carcinoma (SCC) represents the most common SCC affecting head and neck region. Long‐term survival of patients with oral is adversely affected by lymph node metastasis further decreased presence extracapsular spread (ECS). Methods Using a case‐control design, preoperative CT scans from metastatic lymphadenopathy were evaluated 2 independent neuroradiologists, blinded to study, for number radiologic parameters, including central necrosis....
Background: Our study quantifies the effectiveness of perioperative pain control in a cohort patients undergoing major head and neck surgery with free flap reconstruction.Our long-term goal is to improve thereby increase mobility, decrease postoperative complications hospital stay.Methods: A retrospective analysis was performed at tertiary, academic surgical oncology program Calgary, Alberta, Canada from January 1, 2015 -December 31, 2015.Pain scores were recorded prospectively.Primary...
Head and neck cancer (HNC) surgical patients experience a high symptom burden. Multiphasic exercise prehabilitation has the potential to improve patient outcomes, implement it into care pathway, perspectives of healthcare providers (HCPs) must be considered. The purpose this study was thus gather feedback from HNC HCPs on building standard pathway. Methods: Semi-structured interviews were conducted with as part feasibility assessing patient-reported physical function, in-hospital...