A5027400977- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Thyroid Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Sexual function and dysfunction studies
- Salivary Gland Tumors Diagnosis and Treatment
- BRCA gene mutations in cancer
- Venous Thromboembolism Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Prostate Cancer Treatment and Research
- Oral microbiology and periodontitis research
- Head and Neck Anomalies
- Intestinal Malrotation and Obstruction Disorders
- Intestinal and Peritoneal Adhesions
- Radiation Dose and Imaging
- Multiple Myeloma Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
McGill University
2008-2025
McGill University Health Centre
2004-2024
Royal Victoria Hospital
2005-2020
Hospital de Especialidades José Carrasco Arteaga
2019-2020
Montreal General Hospital
2018
Royal Victoria Regional Health Centre
2005
Instituto de Investigación Nutricional
1990
Background: Although the current gold standard for diagnosing thyroid nodule malignancy is ultrasound-guided fine-needle aspiration (FNA) cytology, about 20-25% of cytological evaluations are considered indeterminate malignancy. This limitation has led to emergence next-generation sequencing panels, example, ThyroSeq v3 (TSv3), which recognize highly diagnostic genetic mutations common carcinomas in FNA samples and classify them as test-negative or test-positive, helping optimize treatment...
Carcinoid tumours are relatively rare and, in general, slow growing. They can be “non-functioning” tumours, presenting as a tumour mass, or “functioning” secondary to the production of several biopeptides leading carcinoid syndrome. Though these represent 0.25% an oncology practice, proper understanding clinical course disease and importance appropriate diagnostic therapeutic measures is very important. Proper patient management lead cure, particularly if fully resected, long-term palliation...
Examine, in a real-world setting, whether strict normalization of modestly elevated insulin-like growth factor 1 (IGF1) results clinical and health-related quality life benefits patients with acromegaly using an open-label, non-randomized, 6-month prospective interventional study. In modest IGF1 elevation, control was achieved by addition or dose escalation pegvisomant. Clinical biochemical parameters were assessed at baseline, 3 months for pegvisomant titration, 6 months. The...
The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome papillary thyroid carcinoma (PTC) have long been a topic controversy.To evaluate effect coexistent CLT clinicopathological features PTC.Retrospective study.All patients with PTC who had followed by 2 co-investigators (Juan Rivera Richard J. Payne) between 2006 2011 were included.CLT was present in 35% (166) included associated higher proportion TNM stage I (p = 0.027) fewer persistent disease 0.014)...
To evaluate demographic data and quality of care patients with acromegaly in Canada their evolution over time secondly, to predictors co-morbidities treatment outcomes.Retrospective analyses clinical, biochemical outcome 649 (males: 50·7%) followed from 1980 2010 (mean 10·2 years, SD 13·7) eight tertiary centres six Canadian provinces.In comparison 1980-1994, the number referred last 15 years was higher female preponderance (52·8% vs 41·4%, P = 0·01) an older age at diagnosis (46·4 ± 14 41·3...
Glucocorticoid resistance syndrome (GRS) is a rare genetic disorder caused by inactivating mutations of the NR3C1 gene which encodes glucocorticoid receptor. The phenotypic spectrum broad but typically include symptoms adrenal insufficiency, mineralocorticoid excess and hyperandrogenism. We report new case associated with novel mutation. A 55-year-old woman lifelong history low body weight, hyperandrogenism anxiety was seen at endocrine clinic after left adrenalectomy salpingoophorectomy for...
Abstract Disclosure: C. Gandhi: None. C.L. Chik: Advisory Board Member; Self; Ipsen, Novo Nordisk, Novartis Pharmaceuticals. Grant Recipient; Pfizer, Inc.. J.A. Rivera: M. Denis: S. Van Uum: Inc., Spruce. D.T. Holmes: Other; Roche Diagnostics. S.Z. Ezzat: Bayer, Eli Lilly & Company, Pharmaceuticals, Merck, Eisai. Objective: Examine, in a real world setting, whether strict normalization of modestly elevated IGF-1 can result clinical and health-related quality life benefits patients with...
Somatostatin (SST) inhibition of hormone hypersecretion from tumors is mediated by somatostatin receptors (SSTRs). SSTRs also play an important role in controlling tumor growth through specific antiproliferative actions. These are well expressed numerous normal and tissues susceptible to regulation a variety factors. Estradiol, potent trophic mitogenic its target tissues, known modulate the expression SST receptors. Accordingly, present study, we determined effects tamoxifen, selective...
Insulinomas are rare, life-threatening pancreatic neuroendocrine tumors. Surgical removal continues to be the treatment of choice, yet it is associated with considerable risk morbidity. Here, we describe our patient insulinoma who was successfully treated radiofrequency ablation.The a 56-year-old man no history diabetes mellitus. He presented recurrent episodes transient ischemic attacks and stroke over last 3 years. Some changes in his behavior memory were noticed by family members. During...
Linear measurements have many limitations. The aim of this study is to compare manual and semiautomated volumetric pituitary adenomas. Magnetic resonance imaging (MRI) scans 38 patients with adenomas were analyzed. Preoperative MRI was acquired on a 1.5 T. volumes the obtained by two methods: (MA) (SA). concurrent validity for SA MA methods in form correlation coefficient 0.97 (p < 0.0001). intraobserver interobserver coefficients both 0.98, as 0.98. Although results are comparable, analysis...
Glucagonomas are rare pancreatic neuroendocrine tumors (pNETs), malignant in 80% of cases, thus highlighting the importance early diagnosis and treatment. Primary manifestations diabetes, dermatosis, depression, weight loss, deep vein thrombosis. Unlike other pNETs, glucagonomas associated with a higher incidence thromboembolic events, often resulting death. We present case glucagonoma patient whose primary manifestation was cerebral sinus venous thrombosis (CS-VT). Early enabled curative...
Hypopituitarism tends to occur in large pituitary adenomas. However, similar tumors could present with strikingly different hormonal deficiencies. In this study, we looked at MRI characteristics non-functioning adenomas (NFPA), which predict secondary adrenal insufficiency (SAI) and central hypothyroidism (CHT). We reviewed the files of patients NFPA attending our clinic. Tumor size, invasiveness, MR-signal intensity, gadolinium enhancement preoperative were recorded along documented...
Abstract Disclosure: C.L. Chik: Advisory Board Member; Self; Ipsen, Novo Nordisk, Novartis Pharmaceuticals. Grant Recipient; Pfizer, Inc.. C. Gandhi: None. J.A. Rivera: M. Denis: S. Van Uum: Inc., Spruce. S.Z. Ezzat: Bayer, Eli Lilly & Company, Pharmaceuticals, Merck, Eisai. D.T. Holmes: Other; Roche Diagnostics. Objective: IGF-1 measurements were transitioned from the IDS-iSYS to Elecsys® immunoassays by central laboratory during our clinical study that assessed strict control (I-Con)...
Introduction: Ectopic secretion of GHRH is a rare cause acromegaly. However, its recognition clinically important because different therapeutic approaches are required. Case Presentation: We present challenging case acromegaly secondary to ectopic from pancreatic neuroendocrine tumor in 52-year-old female. The patient treated with modalities which include pegvisomant an attempt control the stimulated GH-axis considering limited data about use treatment Conclusion: GHRH-secreting Surgical...