A5085568923- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Adrenal and Paraganglionic Tumors
- Bone Metabolism and Diseases
- Graphene and Nanomaterials Applications
- Dietary Effects on Health
- Bone health and treatments
- Ovarian function and disorders
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Ophthalmology and Eye Disorders
- Diabetes Management and Education
- Diabetes Management and Research
- COVID-19 and healthcare impacts
- Nanoparticle-Based Drug Delivery
- Erythrocyte Function and Pathophysiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neuroendocrine Tumor Research Advances
King Saud University
2017-2025
King Saud Medical City
2020-2025
King Khalid University Hospital
2016-2022
Thyroid hormone is a potent stimulator of metabolism, playing critical role in regulating energy expenditure and key physiological mechanisms, such as growth development. Although administration thyroid the form levo thyroxine (l-thyroxine) has been used to treat hypothyroidism for many years, precise molecular basis its actions remains uncertain. Our objective was define changes circulating protein levels that characterize alterations status. To do this, an integrated untargeted proteomic...
Insulin resistance is a hallmark feature of type-2 diabetes mellitus (T2DM). We determined the homeostatic model assessment insulin (HOMA-IR) and evaluated its association with C-peptide, insulin, fasting blood glucose (FBG) glycated hemoglobin (HbA1c) in T2DM patients non-diabetic subjects. This study comprised total 47 38 controls. Venous samples from all subjects were collected sera analyzed for FBG, HbA1c, C-peptide using an autoanalyzer. HOMA-IR was calculated following equation: =...
Coronavirus disease 2019 (COVID-19) has evolved into a devastating pandemic since December 2019. Saudi Arabia's first case was reported in March 2020. Subsequently, some 220,000 cases and 2000 deaths were recorded through July COVID-19 infection aggravates glycemic control provokes acute hyperglycemic crises, according to reports. We made the same observations of our patients diagnosed with COVID-19. However, we are unaware any diabetic ketoacidosis (DKA) among Arabia.Highlighting...
Background Bethesda III and IV thyroid nodules continue to be difficult manage. Although molecular testing may assist in decision-making, it is expensive, not widely available, without pitfalls. The objective of this study assess whether certain ultrasonographic features predict the risk cancer patients with used as additional decision-making tools complement cytopathological results deciding on diagnostic thyroidectomy. Methods We retrospectively evaluated categories who underwent...
Introduction and importance: Severe hypertriglyceridemia is increasingly leading to referrals endocrinology clinics. Patients commonly present with clinical manifestations such as recurrent abdominal pain, acute pancreatitis, eruptive xanthomas. Case presentation: We report the case of a young male patient over 30 episodes pancreatitis extremely elevated triglyceride levels. Genetic testing identified heterozygous pathogenic mutation in 1-acylglycerol-3-phosphate-o-acetyltransferase 2...
Clinical practice guidelines (CPGs) are significant tools for evidence-based health care quality improvement. The CPG program at King Saud University was launched as a improvement to fulfil the international accreditation standards. This collaboration between Research Chair Evidence-Based Healthcare and Knowledge Translation Quality Management Department. study aims develop fast-track method adaptation of CPGs describe results program.Twenty-two clinical departments participated in program....
Thyroid hormones critically modulate body homeostasis and haemostasis by regulating energy metabolism. Previous studies have focused on individual pathways or proteins that are affected increases in thyroid hormone levels, while an overall plasma proteomic signature of this increased level is lacking. Herein, integrated untargeted approach with network analysis was used to identify changes circulating the proteome between hyperthyroid euthyroid states. Plasma from 10 age-matched subjects at...
Primary Empty Sella (PES) syndrome is an increasingly common disorder, mostly diagnosed as incidental finding during brain imaging scans. We intended to review the clinical management and hormonal profile of patients with PES.The study included ten-year retrospective analysis registry containing PES cases in period 2007 2017, from a single tertiary care center. The keyword 'primary empty sella' was used retrieve patient details radiology unit. biochemical analyzed. Case their rate referral...
Diabetes mellitus is a chronic multisystem disease with high global prevalence, including in Saudi Arabia. The Glucagon-like Peptide (GLP-1) receptor agonist liraglutide known to lower glucose levels, reduce weight and improve cardiovascular outcome. However, mechanisms underlying the benefits of treatment patients type 2 diabetes (T2DM) remain unclear.In present study, 2D-DIGE MALDI-TOF mass spectrometric approach combined bioinformatics network pathway analysis explore plasma proteomic...
Cancer is a leading cause of death worldwide. Conventional methods cancer treatment, including chemotherapy and radiotherapy, are associated with multiple side effects. Recently, photodynamic therapy (PDT) has emerged as an effective therapeutic modality for treatment without adversely affecting normal tissue. In this study, we synthesized nitrogen doped graphene (NDG) conjugated it Mn3O4 nanoparticles to produce NDG-Mn3O4 nanocomposite the aim testing its bimodal performance PDT magnetic...
Background: Graphene-based nanomaterials possess unique optical, physicochemical and biomedical properties which make them potential tools for imaging therapy. Manganese oxide nanoparticles are attractive candidates contrast agents in magnetic resonance imagint (MRI). We used manganese (Mn3O4) highly reduced graphene (HRG) to synthesize hybrid (HRG-Mn3O4) tested their efficacy photodynamic therapy (PDT) breast cancer cells. Methods: The newly synthesized were characterized by transmission...
Aim: To compare the effects of 5- and 50-nm naked PEG-coated gold nanoparticles (AuNP) on proinflammatory cytokines (IL-1β, IL-6, TNF-α) expression histopathological changes in liver kidneys rats. Materials & methods: Rats were injected with different sacrificed after 24 h. Results: Both AuNPs, PEG-AuNPs caused granular clumping cytoplasm, edema hydropic dystrophy hepatic cells. Naked AuNPs both sizes mild shrinkage, whereas enlarged Bowman's space capsule. Larger produced more profound mRNA...
Primary adrenal lymphoma is an extremely rare condition. We describe a case of bilateral in man aged 55 years who was admitted to our hospital. He had 3-month history left flank pain, nausea and vomiting with weight loss. A CT scan at private hospital revealed large masses; the patient referred centre based on these findings. evaluated for pheochromocytoma by endocrinology team; however, all findings were negative. In addition, cosyntropin stimulation test indicated insufficiency. Trucut...
The thyroid gland and hormones control a multitude of homeostatic functions including maintenance fluid electrolyte balance normal functioning the kidneys. Thyroid dysfunction alters sytemic hemodynamic metabolic balance, thereby affecting kidney. In this study, we aimed to identify characterize urinary proteome patients with hypothyroidism. An untargeted proteomic approach network analysis was used changes in total newly diagnosed overt Urine samples were collected from nine age-matched...
Thyroid function tests (TFTs) changes in obese people have been studied with increasing interest, however, studies inconsistent hence it remains poorly understood. We compared the TFTs of morbidly euthyroid Saudi subjects non-obese controls and then we examined influence leptin, adiponectin, insulin resistance on TFTs.Fifty-five attending bariatric surgery clinic 52 age-and gender-matched were recruited. measured body weight, BMI, composition, thyroid-stimulating hormone (TSH), Free T4...
Periodontal disease is a chronic infectious disease, which characterized by the damaged dental hard tissue lactic acid generated microorganisms after fermentation of carbohydrates rich diet. The risk periodontal known to be higher in diabetic patients. We compared diversity five commonly occurring bacteria including Porphyromonas gingivalis, Tannerella forsythia, Capnocytophaga ochracea, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans 14 type-2 patients equal numbers healthy...
The TBX1 gene encodes the T-box 1 protein that is a transcription factor involved in development. Haploinsufficiency of reported to cause features similar DiGeorge syndrome. located within syndrome region, and studies support TBX1gene responsible for most phenotype hemizygous deletion chromosome 22q11.2. In this study, we report family 4 (a father with 3 children) who presented congenital hypoparathyroidism hypocalcemia, facial asymmetry, deafness, normal intelligence, no cardiac...