Abstract In observational studies, type-2 diabetes (T2D) is associated with an increased risk of coronary heart disease (CHD), yet interventional trials have shown no clear effect glucose-lowering on CHD. Confounding may therefore influenced these estimates. Here we use Mendelian randomization to obtain unconfounded estimates the influence T2D and fasting glucose (FG) CHD risk. Using multiple genetic variants FG, find that increases (odds ratio (OR)=1.11 (1.05–1.17), per unit increase in...

Objective Chronic hyperglycemia induces pathogenic changes in the vascular endothelium and leads to development of microvascular complications patients with type 2 diabetes mellitus. Early identification markers may help minimize risk progression complications. Methods This follow-up study was conducted diabetic cohort aged between 30-70 years. Out 160 eligible participants, 70 them completed follow-up. Levels cell adhesion molecules selectins (VCAM-1, ICAM-1, E-selectin, L-selectin...

ABSTRACT Type-2 diabetes (T2D) is associated in observational studies with both higher bone mineral density (BMD) and fracture risk for given BMD. These relationships may however be confounded by factors such as body mass index (BMI). Here we used Mendelian randomization (MR) to obtain non-confounded estimates of the effect T2D glycemic traits on We identified genetic variants strongly (34,840 cases 114,981 controls) fasting glucose (133,010 nondiabetic individuals), but not BMI, determined...

Women are at increased risk of developing kidney disease and cardiovascular (CVD) in their middle older ages due to the impact aging hormonal variation associated with menopause transition. diabetes greater reduced function. Reduced or even mildly function enhances atherosclerotic (ASCVD) among women type 2 (T2D). Thus, objective this study is determine association an estimated 10-year ASCVD, CVD, factors T2D women. This cross-sectional conducted 393 women, aged between 40-70 years,...

Metformin is a widely prescribed medication for the treatment of type 2 diabetes mellitus (T2DM). It possesses effective roles in various disorders, including cancer, dyslipidemia, and obesity. However, underlying mechanisms metformin's multiple benefits are not fully understood. Herein, mass spectrometry-based untargeted metabolomics approach was used to investigate metabolic changes associated with administration single dose metformin plasma 26 healthy subjects at five-time points;...

Neuropathy is the most common microvascular complications among diabetic patients. Diabetic peripheral neuropathy (DPN) predominant variety which may associate with increased in mortality and morbidity type 2 diabetes mellitus (T2DM).To assess prevalence of its correlation risk factors T2DM.This was a cross-sectional retrospective study, data collected from previous cohort study conducted at University Diabetes Center, King Saud Medical City (KSUMC), University, Riyadh, Saudi Arabia. The...

Metformin is widely used in the treatment of Type 2 Diabetes Mellitus (T2DM). However, it known to have beneficial effects many other conditions, including obesity and cancer. In this study, we aimed investigate metabolic effect metformin T2DM its impact on obesity. A mass spectrometry (MS)-based metabolomics approach was analyze samples from two cohorts, healthy lean obese control, as well patients regimen last 6 months. The results show a clear group separation sample clustering between...

Abstract Background QT prolongation increases cardiovascular mortality in diabetes. The risk factors for vary across different studies. There is no data on the patients with diabetes from Arab region, where highly prevalent. Here we aimed to assess prevalence of and its associated type 2 Saudi Arabia. Method This was a retrospective, cross-sectional, hospital-based file review study. Data were collected medical records aged above 14 years underwent ECG examination, laboratory investigations...

The most prevalent comorbidity among cystic fibrosis (CF) patients is fibrosis-related diabetes (CFRD). CFRD has been linked to one of the worse clinical outcomes and a higher mortality. Improved results have related earlier diagnosis treatment CFRD. Therefore, present study aimed investigate metabolome human serum with This might aid in identifying novel biomarkers pathophysiology its diagnosis. liquid chromatography–high-resolution mass spectrometry (LC–HRMS) metabolomics approach was...

Analyzing urinary biomarkers may provide better insight into pathophysiological mechanisms of diabetic kidney diseases. The study aimed to analyze the pattern selected excreted and its correlation with albuminuria estimated glomerular filtration rate (eGFR) in patients type 2 diabetes.A total 185 diabetes were categorized according KDIGO guideline based on eGFR. markers (transferrin, KIM-1, RBP, MCP-1 NGAL) measured by ELISA.The associated eGFR (total protein/Cr, p=0.001; RBP/Cr, p=0.007;...

Primary Empty Sella (PES) syndrome is an increasingly common disorder, mostly diagnosed as incidental finding during brain imaging scans. We intended to review the clinical management and hormonal profile of patients with PES.The study included ten-year retrospective analysis registry containing PES cases in period 2007 2017, from a single tertiary care center. The keyword 'primary empty sella' was used retrieve patient details radiology unit. biochemical analyzed. Case their rate referral...

The coronavirus disease of 2019 (COVID-19) pandemic significantly affected different life aspects, including healthcare communities and academic institutes. We aimed to assess the level stress risk factors among medical students interns during COVID-19 in setting middle east respiratory syndrome -CoV endemic area.A questionnaire-based cross-sectional study was conducted on a randomly selected sample interns. questionnaire anonymously self-administered indicate perceive hygienic practice...

Metformin is an orally effective insulin-sensitizing drug widely prescribed for treating type 2 diabetes mellitus (T2DM). has been reported to alter lipid metabolism. However, the molecular mechanisms behind its impact on metabolism remain partially explored and understood. In current study, mass spectrometry-based profiling was used investigate lipidomic changes in serum of 26 healthy individuals after a single-dose intake metformin. Samples were analyzed at five-time points:...

Background: Obesity and type 2 diabetes mellitus (T2DM) are characterized by underlying low-grade chronic inflammation. Metformin has been used as the first line of therapy in T2DM it decreases hepatic glucose production intestinal absorption, enhances insulin sensitivity weight loss, is known to ameliorate The mechanisms through which metformin exerts its effect remain unclear. Proteomics emerged a unique approach explore biological changes associated with diseases, including T2DM. It...

AIMTo determine the clinical and biological characteristics of double diabetes (DD) among young people in Saudi Arabia. CONCLUSIONOur findings enable us to arrive at conclusion that almost one-third diabetic patients reveal atypical forms DM (double diabetes) expressing features resulting from both T1D T2D.

Background The Bethesda System for Reporting Thyroid Cytolopathology (TBSRTC) is the standardized category-based reporting system thyroid nodule (TN) aspirations; however, atypia of undetermined significance/follicular lesion significance (Bethesda category III, AUS/FLUS) most controversial category. aim this study was to identify degree malignancy risk and related factors in surgical pathology Category III nodules. Methods A total 4074 patients (15-90 years, 81.5% females) were subjected...

The study considered the long-term outcome of patients with papillary thyroid carcinoma treated 30 mCi radioiodine.The aims this were to define and compare remission rates ablated (131)I prepared by either hormone withdrawal (THW) or recombinant human thyrotropin (rhTSH; Thyrogen(®)), identify variables predictive a favorable prognosis.An observational was conducted at an academic medical center comparative summary six studies is presented. Three hundred seventy (THW group, n = 203; rhTSH...

The incidence and mortality of endometrial cancer (EC) have increased in recent years. There is mounting evidence that diabetes may play a role the greater EC. molecular mechanisms interaction between type 2 EC are not yet clearly understood yet. present study was undertaken to investigate plasma proteomics patients with comparison those without diabetes. Plasma samples were obtained from age-matched (EC diabetic nondiabetic). Untargeted proteomic analysis carried out using two-dimensional...

Semaglutide, a Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA), is often prescribed for managing type 2 diabetes, particularly in cases unresponsive to other hypoglycemic agents. Despite its popularity, the real-world efficacy and cost-effectiveness of Semaglutide relative treatments remain understudied. This study aimed examine direct medical cost consequences adding treatment regimen diabetes patients Saudi Arabia. We conducted single-center, retrospective review Electronic Medical...

<h3>Objectives:</h3> To investigate the safety and cost-effectiveness of outpatient thyroidectomy provide a systematic postoperative protocol for safe discharge. <h3>Methods:</h3> In this retrospective review, medical records all patients who underwent total, hemi, or completion from July 2017 to April 2019 at 2 tertiary care hospitals were reviewed. Multivariable analysis was performed on potential predictors complications. Healthcare costs calculated by type admission based average...