A5002247137- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Endometriosis Research and Treatment
- Biosensors and Analytical Detection
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Adrenal Hormones and Disorders
- Advanced Biosensing Techniques and Applications
- Ureteral procedures and complications
- Kruppel-like factors research
- Peptidase Inhibition and Analysis
Sichuan University
2015-2024
West China Second University Hospital of Sichuan University
2016-2024
Ministry of Education of the People's Republic of China
2020
Fudan University
2011
Institute of Genetics
2011
State Key Laboratory of Genetic Engineering
2011
Aims . Previous evidence has proved that interleukin-31 (IL-31) and interleukin-33 (IL-33) can be potential markers in some cancers’ formulation. We aimed to determine the role of IL-31 IL-33 prognosis endometrial cancer patients. Methods Serum samples were collected from 160 patients with healthy controls. The ELISA kits (Raybio® Systems) specific for human used. levels tumor (CEA, CA-125, CA19-9) measured by chemiluminescence immunoassay. A two-side P value < 0.05 was indicated...
Ovarian cancer (OC) is a gynecological with high mortality. OC-derived exosomal circRNAs can regulate angiogenesis. This study aims to explore the role and mechanism of circRNA nuclear factor I X (CircNFIX) derived from OC cells in Quantitative real-time polymerase chain reaction was employed evaluate levels circNFIX, miR-518a-3p, tripartite motif protein 44 (TRIM44) adjacent tissues. Exosomes ovarian surface epithelial cell (HOSEpiC) (SKOV3 or OVCAR3) were isolated by differential...
Endometrial cancer (EC) is the most prevalent gynecological epithelial malignancy. DNA methylation a promising biomarker but limited use for detecting EC. We previously found that level of cysteine dioxygenase 1 (CDO1) promoter was elevated in EC patients through methylomics, role and mechanism CDO1 remained unclear. Here, detected by bisulfite-sequencing PCR methylation-specific (bisulfite conversion-based methods, which remain commonly used techniques detection). Cells were incubated with...
Interleukin-32 (IL-32), a pro-inflammatory chemokine, has been reported to be involved in inflammatory, infectious diseases and even cancers. This study aimed investigate whether two genetic variants (rs28372698 rs12934561) of IL-32 were associated with susceptibility endometrial cancer (EC) Chinese Han women by hospital-based 272 EC patients 337 healthy controls. Our results showed that the frequencies TT genotype (P = 0.012, OR 2.37, 95 % CI 1.32–4.28) T allele 0.026, 1.320, 1.036–1.681)...
Safer, more convenient methods for cervical sample collection and storage are necessary to facilitate human papillomavirus (HPV) DNA testing in low-resource settings. Our study aimed evaluate the stability of specimens collected with dry swabs stored dry, compared liquid-based cytology (LBC) samples, as detected by HPV testing. Women abnormal cytological findings or HPV-positive results at colposcopy were recruited from West China Second University Hospital, Sichuan University, between...
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, secreted protein, has been reported to be associated with several diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in published report on the same population. In order elucidate correlation between and SLE, we determined level two single nucleotide polymorphisms (SNPs) of 152 patients SLE 310 healthy controls analyzed relationship based clinical parameters. The...
Primary perivascular epithelioid cell tumors (PEComas) of the female reproductive tract have been primarily reported as case reports owing to their clinical rarity. Limited incidence rates and data hinder a comprehensive understanding risks invasiveness this disease. We discuss herein diagnosis, treatment, prognosis disease enhance comprehension therapeutic strategies.
Ovarian cancer (OC) is the leading cause of gynecologic cancer-related death in world. Accumulating evidence indicated important role TRIM44 development. However, how displays OC and underlying mechanism remained unclear. FRK expression tissues cell lines were investigated by western blot RT-qPCR. Histotype tissue samples patients' data analyzed. Kaplan-Meier Curve was performed to validate effect TRIM44. Colony formation assay, MTT Transwell wound-healing assay applied elucidate function...
Abstract Aim The aim of this study was to investigate whether a functional insertion/deletion polymorphism (rs3783553) located in the 3′‐untranslated regions interleukin‐1 A is associated with susceptibility endometrial cancer (EC) Chinese Han women. Methods total 272 patients and 294 age‐matched healthy controls were included study. genotype rs3783553 determined by polymerase chain reaction polyacrylamide gel electrophoresis. Results Our results showed that significantly reduced risk EC...
We aimed to study the regulatory roles and mechanism of circular nuclear factor IX (circNFIX) in cancer growth stemness properties ovarian (OC). CircNFIX SH3RF3 levels OC tissues cells were tested by quantitative real-time PCR. RNase R treatment quantified circNFIX RNA stability. Molecular interaction among circNFIX, LIN28B, was predicted bioinformatics software validated through immunoprecipitation (RIP) assay. The gain- or loss-experiments on capabilities metastasis vitro assessed using...
To evaluate the association between Foxp3 gene polymorphisms (rs3761548 and rs5902434) susceptibility to endometrial cancer (EC), we report a hospital case–control study involving 602 women, consisting of 269 patients with EC 333 healthy controls. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Our results suggest that frequency A allele in rs3761548 significantly lower than controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence...
Abstract Background Endometrial cancer is one of the three most common malignancies in female genital tract. Previous studies have demonstrated association between heparanase ( HPSE , OMIM 604,724) single‐nucleotide polymorphism (SNP) and risk several cancers. However, its role endometrial remains unclear. The present study investigated effects SNPs on susceptibility clinicopathological parameters patients with cancer. Methods rs4693608 (G > A) rs4364254 (C T) were analyzed using...
e17565 Background: BRCA1 and BRCA2 are tumour suppressor genes, involved in the homologous repair of double-stranded DNA breaks, located at 17q21.31 13q13.1, respectively. Germline BRCA1/2 mutations identified 13-15% ovarian cancers (OC), while an additional 5-7% harbor somatic among foreign populations. To determine landscape germline pathogenic alterations Chinese patients with cancer tested by next‐generation sequencing (NGS), aim defining best strategy to be implemented future routine...
Objectives: In this retrospective observational study, cases from our institution were included and the published literature reviewed to investigate diagnosis prognosis of cervical rhabdomyosarcoma, a rare group tumours. Material methods: The clinicopathological data 12 patients with rhabdomyosarcoma (RMS) treated at West China Second University Hospital Sichuan January 2006 May 2023 collected, their characteristics, diagnoses, treatments, prognoses pregnancy outcomes retrospectively...
Runt‑related transcription factor 3 (RUNX3) is a member of Runt domain family that known to play key roles in various different types tumor. It was recently demonstrated RUNX3 may also be associated with cervical cancer. The aim the present study investigate potential association between transcriptome changes and expression A overexpression model constructed using cancer cell lines by plasmid transfection. upregulated inhibited proliferation lines, particularly SiHa cells, IL‑6, PTGS2, FOSL1...
Vesicovaginal fistula (VVF) which refers to the abnormal passage between bladder and vagina, is most distressing complication of gynecologic surgery, VVF mostly occurs in complete hysterectomy. Most caused by inadvertent injury during surgery operators. According symptoms leakage urine, combined with methylene blue test cystoscopy, can usually be exactly diagnosed. Surgical repair aims at correcting urine efflux main treatment method for VVF.The timing approach surgical operation should...
Abstract Background: Embryonal rhabdomyosarcoma (ERMS) of the uterine cervix is rare, but population affected mostly underage females. The scope surgery has now evolved from extensive to limited, and organ-preserving combined with chemotherapy recommended preserve patient's fertility. However, reports birth outcomes are rare. Case: A minor woman cervical ERMS who underwent only an outpatient biopsy lesion, had no residual lesion on subsequent multipoint refused radical or conization, after...