A5103058973- Biological and pharmacological studies of plants
- Toxin Mechanisms and Immunotoxins
- Cancer-related molecular mechanisms research
- Neonatal and fetal brain pathology
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
Xiangya Hospital Central South University
2021
Central South University
2021
Yanbian University Hospital
2019
Background Ferroptosis is a form of regulated cell death that damages neurons in the central nervous system. In this study, we aimed to construct ferroptosis-related gene signatures temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and explore their diagnostic role TLE-HS. Methods The GSE205661 dataset was acquired for training purposes, while GSE71058 obtained serve as validation dataset. Subsequently, differentially expressed genes (FR-DEGs) TLE-HS were further analyzed. We used...
Elucidating the dysregulated metabolic pathways in cancer cells and their relevance to cisplatin resistance could yield new insights into therapy. We previously reported that eight metabolites involved tricarboxylic acid (TCA) cycle glutamine metabolism were associated with platinum-based chemotherapy efficacy human lung cancer. Here, we investigated differences upon treatment vitro vivo. A simple partially validated standard addition method was applied for quantification of five TCA using...