A5103263953- Circular RNAs in diseases
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Fungal Biology and Applications
- Synthesis and Reactions of Organic Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Synthesis of heterocyclic compounds
- Cancer-related molecular mechanisms research
- Fluorine in Organic Chemistry
Yanbian University Hospital
2019-2024
Yanbian University
2020
Abstract In this study, we investigated the role and mechanism of imperatorin (IMP) in chronic inflammation airway remodeling. The levels TNF-α, IL-1β, IL-6, IL-8, VEGF, α-SMA, ROS were detected by ELISA, immunohistochemistry (IHC), immunofluorescence, Western blot. addition, evaluated effect IMP on MAPK, PI3K/Akt, NF-κB, Nrf2/HO-1 signaling pathways. treatment obviously attenuated production inflammatory cytokines cells bronchoalveolar lavage fluid OVA-induced remodeling model. Meanwhile, it...
This study aims to analyze the relationship between Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor-erythroid 2-related factor 2 (Nrf2) and Epilepsy (EP), as well its mechanism of action. Thirty Wistar rats were divided into a control group (without treatment), model (EP modeling), an inhibition modeling + intervention by Keap1/Nrf2 signaling pathway inhibitor ATRA) subject Morris water maze experiment. Then, expression Oxidative Stress (OS) markers, ferroptosis-associated...