A5101428928- HIV Research and Treatment
- Alzheimer's disease research and treatments
- Mental Health Research Topics
- Cholesterol and Lipid Metabolism
- Genetic Neurodegenerative Diseases
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Cytomegalovirus and herpesvirus research
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Grit, Self-Efficacy, and Motivation
- Polyomavirus and related diseases
- HIV-related health complications and treatments
- Full-Duplex Wireless Communications
- Ginseng Biological Effects and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bioinformatics and Genomic Networks
- Neurological disorders and treatments
- Gut microbiota and health
- Cholinesterase and Neurodegenerative Diseases
- Healthcare Decision-Making and Restraints
- Hormonal and reproductive studies
- Metalloenzymes and iron-sulfur proteins
National Clinical Research Center for Digestive Diseases
2020-2025
Capital Medical University
2012-2025
Chinese Institute for Brain Research
2025
North Sichuan Medical University
2020-2022
Xuan Wu Hospital of the Capital Medical University
2018-2019
Yantai University
2018
Beijing Shijingshan Hospital
2017
Jiangsu University
2008-2009
China has a large population of older people, but not yet undertaken comprehensive study on the prevalence, risk factors, and management both dementia mild cognitive impairment (MCI).For this national cross-sectional study, 46 011 adults aged 60 years or were recruited between March 10, 2015, Dec 26, 2018, using multistage, stratified, cluster-sampling method, which considered geographical region, degree urbanisation, economic development status, sex age distribution. 96 sites randomly...
ABSTRACT Aims To analyze the effect of APOE ε 4 on fluid biomarkers and correlations between blood molecules CSF in AD patients. Methods This study enrolled 575 patients, 131 patients with non‐AD dementia, 112 cognitively normal (CN) participants, were divided into carriers non‐carriers. Cerebrospinal (CSF) blood‐derived biomolecules compared CN groups, dementia as well within subgroups Utilizing Spearman's correlation analysis quantile regression analysis, relationships analyzed Results The...
Abstract Introduction The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the genetic features of FAD pedigrees and without mutations. Methods In total, 1330 (AD) or mild cognitive impairment 404 were enrolled from Familial Disease Network. mutations APOE frequencies determined. Results 13.12% carried missense mutations, 3.71% synonymous/untranslated region variants, 83.17% did not carry Eleven first identified....
Abstract Background Mutations in the mitochondrial alanyl‐transfer (t) RNA synthetase 2 ( AARS , OMIM :612035) have been linked to leukoencephalopathy recently. Till now, there 19 cases reported so far. However, clinical and genetic characteristics of this disease are not fully understood. We an adult‐onset male patient related novel gene mutations reviewed all previous regarding features leukoencephalopathy. Methods The spectrum symptoms analysis presented were identified investigated....
Background Myelin oligodendrocyte glycoprotein-antibody (MOG-ab)-associated disease (MOGAD) has highly heterogenous clinical and imaging presentations, in which encephalitis is an important phenotype. In recent years, some atypical presentations MOG-ab-associated (MOG-E) have been increasingly reported but not yet described well. The aim of the study was to describe features patients with MOG-E our center. Atypical phenotypes would be reported, expected expand spectrum MOGAD. Methods We...
Our recent study showed that almost equal proportions of B, CRFs_BC, and CRF01_AE were circulating among MSM in Jiangsu, suggesting there is a very high likelihood generating new intersubtypes/CRFs recombinants. Here, we report an epidemiologically linked cohort including 22 HIV-1-positive IDUs Jiangsu. Fifteen blood samples collected to investigate HIV-1 subtype characterization. The analyses gag-RT regions 14 these belonged CRF07_BC. Importantly, detected, for the first time, novel...
To present detailed information regarding these aspects in Human Immunodeficiency Virus (HIV)-infected patients making an effort to improve the recognition of neurological complications HIV infection.This retrospective study analyzed clinical manifestations, laboratory and neuroimaging results HIV-infected with at Xuanwu hospital, Beijing, China from January 2011 December 2014, one top-rated hospitals China.A diverse range diagnoses was identified, including encephalopathy,...
Purpose of the study Cerebrotendinous xanthomatosis (CTX) is an inherited disorder associated with abnormal deposition cholestenol in brain and other tissues. Here we report a Chinese family two affected members CTX.Materials Methods Clinical data were collected. Gene analysis, MRI, neuropsychological assessments, biopsy right Achilles tendon xanthoma carried out.Results The cases had similar symptoms for cataracts, chronic diarrhea, progressive cognitive impairment disturbance gait,...
The occurrence of a novel CRF01_AE-associated recombinant in Jiangsu implies the importance characterizing full-length CRF01_AE genomic sequence from injecting drug users (IDUs). Here, we reported near 07JSWX045 obtained IDU, using modified method. analyses revealed several interesting findings. First, was phylogenetically close to strains circulating among men who have sex with (MSM), implying recent common ancestor. Second, not genetically associated part new CRF01_AE/07_BC found Jiangsu....
This study aimed to investigate the therapeutic mechanism of Huankuile suspension (HKL), a typical traditional Chinese medicine, on ulcerative colitis (UC) in rat model. UC model was established by 2,4,6-trinitrobenzene sulfonic acid (TNBS) enema. Then, rats were randomly divided into three groups: water treated group, HKL group and 5- amino salicylic (5-ASA) group. After 7 days treatment, histological score comparable with those control qRT-PCR western blot demonstrated that could...
Social cognition impairment has been recognized as an early and characteristic change in behavioral variant frontotemporal dementia (bvFTD). The Mini Cognition Emotional Assessment (mini-SEA) is a clinical tool to rapidly evaluate social cognition. In this study, we explored the diagnostic value of by assessing Chinese version mini-SEA other standard neuropsychological tests 22 patients with mild bvFTD, 26 Alzheimer's disease (AD), including cognitive (MCI) dementia, 30 control subjects....
Objective To explore mediating effect of coping style on the relationship between self-esteem and negative emotions among college students with left-behind experience. Methods The investigation was carried out 663 experience by multistage sampling method, using scale, self-rating anxiety scale Beck depression inventory. Results Scores all scales were shown as follows: (3.09±0.51), (34.94±7.90), (8.80±8.72), solving problem (9.03±2.57), help-seeking (5.70±2.24), self-blaming...
Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating lytic brain infection caused by the John Cunningham virus (JCV). JCV manifests primarily in patients with innate immunodeficiency or taking immunomodulatory medications. In this case study, we report PML patient comorbid mediastinal teratoma and mild lymphopenia. Case presentation A 73-year-old female presented 3-month history of progressive hemiplegia, hemianopsia, cognitive impairment. She was...