A5100322700- Dental Health and Care Utilization
- SARS-CoV-2 and COVID-19 Research
- Oral microbiology and periodontitis research
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Dental Research and COVID-19
- Food Security and Health in Diverse Populations
- HIV/AIDS oral health manifestations
- Balance, Gait, and Falls Prevention
- Pediatric health and respiratory diseases
- HIV/AIDS drug development and treatment
- Vaccine Coverage and Hesitancy
- Bipolar Disorder and Treatment
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- Non-Invasive Vital Sign Monitoring
- SARS-CoV-2 detection and testing
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- Substance Abuse Treatment and Outcomes
- Health disparities and outcomes
- Context-Aware Activity Recognition Systems
- Health Education and Validation
- Stroke Rehabilitation and Recovery
- Bone fractures and treatments
University of California, Los Angeles
2015-2025
Wenzhou Medical University
2020-2025
University of Winnipeg
2025
Hainan Medical College Hospital
2025
Ningbo No. 2 Hospital
2025
Beijing Wuzi University
2024
Beijing VDJBio (China)
2024
Institute of High Energy Physics
2024
Jilin Academy of Agricultural Sciences
2023
George Washington University
2022-2023
This study evaluated SARS-CoV-2 infection impacts on clinical characteristics, antibody levels, and immune responses in 100 malignant hematological tumor patients. Laboratory assessments included hematological, biochemical, inflammatory markers. Multivariable analysis identified age (OR = 1.56, p 0.004), chemotherapy cycles 1.86, < 0.001), comorbidities 3.15, 0.015), WBC count 1.79, 0.016), CRP 2.07, 0.007), ferritin 1.22, 0.035), IL-6 1.59, IgG 2.28, 0.037), CD8+ T cells 2.97, 0.005), NK...
MAPK targeting in cancer often fails due to reactivation. MEK inhibitor (MEKi) monotherapy provides limited clinical benefits but may serve as a foundation for combination therapies. Here, we showed that combining type II RAF (RAFi) with an allosteric MEKi durably prevents and overcomes acquired resistance among cancers KRAS, NRAS, NF1, BRAF non-V600, V600 mutations. Tumor cell-intrinsically, RAFi plus sequester complexes, reduce MEK/MEK dimerization, uncouple from ERK acquired-resistant...
We present the first ab initio prediction of localized electronic excited states in a periodically infinite condensed phase, heretofore intractable goal. In particular, we examined local excitations within CO molecule adsorbed on Pd(111). The calculation allows configuration interaction treatment region, while its with extended phase is described via an embedding potential obtained from periodic density functional theory. Our work lays foundation microscopic understanding photochemistry and...
Background: Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance hypothalamic–pituitary–adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), commonly used Ayurvedic medicine for relief ameliorating HPA-axis dysfunction. The aim this study was support role root leaf water-extracted ashwagandha extract (WS) reduction by confirming lowest...
This paper examines the heterogeneity in households' expectations of house price growth using micro-level survey data from Federal Reserve Bank New York (FRBNY). The findings reveal that: (i) Households exhibit systematically different forecasts for based on observable characteristics; (ii) perceived uncertainty surrounding these also varies across demographic groups, with this linked to amount attention households pay housing market information; and (iii) revise their over time ways that...
Rapid initiation of antiretroviral therapy (ART) in people living with HIV (PLWH) is crucial for achieving viral suppression and improving clinical outcomes. Serum lactate dehydrogenase (LDH) levels serve as a readily accessible rapid biomarker, has significant predictive potential various diseases. This study aims to evaluate the value LDH context ART initiation. were measured 393 newly diagnosed PLWH who received subsequently followed up. The stratified based on tertile endpoints....
Objective: This cross-sectional study evaluates the association between oral microbiome and presence of untreated dental caries among Kenyan children adolescents living with HIV (CALHIV). Methods: We collected 83 swab samples from CALHIV receiving medical care at Kenyatta National Hospital. used 16S rRNA sequencing technique on to profile bacterial composition. Only results examinations simultaneously were included in further analysis. compared alpha beta diversity individuals without...
Objective: Schistosoma mansoni (S. mansoni) infection is endemic in fishing communities. We investigated its potential impact on Hepatitis B (Hep B) vaccine responses and role mediating the association between gut microbiome long-term effectiveness of response. Methods: Participants were tested for S. infections at baseline received Hep baseline, month 1, 6. Those with treated. Stool samples collected analyzed using 16S rRNA sequencing. The Wilcoxon rank-sum test was used to compare alpha...
Background Few studies have discussed the health benefits of total dietary intake live microbes (TDIIM). We investigated relationship between daily estimated TDIIM and mortality in US adults. Materials methods This cohort study included subjects ≥18 years from 1999–2018 NHANES their data through December 31, 2019. The counts were based on a prior classification system, with foods categorized into low (&lt;10^7 CFU/g), medium (10^7–10^10 high (&gt;10^10 CFU/g) levels microbes....
Introduction: To provide a comprehensive assessment of temporal trends in migraine prevalence among women childbearing age (WCBA) at global, regional and national levels from 1992 to 2021, with particular emphasis on examining the associations between patterns age, period birth cohort effects across different sociodemographic index (SDI) regions. Methods: We conducted secondary analysis data Global Burden Disease Study 2021. Migraine estimates 95% uncertainty intervals (UI) for WCBA were...
Objective: Schistosoma mansoni (S. mansoni) infection is endemic in Ugandan fishing communities. We investigated its potential impact on Hepatitis B (Hep B) vaccine responses and role mediating the association between gut microbiome long-term effectiveness of vaccine. Methods: Participants were tested for S. infections at baseline received Hep baseline, month 1, 6. Those with treated. Stool samples collected analyzed using 16S rRNA sequencing. The Wilcoxon rank-sum test was used to compare...
Background: Dental caries is the most common chronic childhood infectious disease and a serious public health problem affecting both developing industrialized countries, yet it preventable in cases. This study evaluated potential of screening for dental among children using machine learning algorithm applied to parent perceptions their child’s oral assessed by survey. Methods: The sample consisted 182 parents/caregivers 2–7 years age living Los Angeles County. Random forest (a algorithm) was...
This study examined the prevalence and correlates of intimate partner violence (IPV) among a cohort racial/ethnically diverse men who have sex with (MSM) in Los Angeles. An ongoing longitudinal MSM Angeles, constructed by design so half participants use substances (SU) are persons living HIV, provided data. Data collection occured between 2014 2020. At semiannual visits, completed computer-assisted self-interview which included questions on substance (past 6 months) experiences IPV 12...
Several animal models have been used to assist the development of vaccines and therapeutics since COVID-19 outbreak. Due lack binding affinity mouse angiotensin-converting enzyme II (ACE2) S protein severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), increasing susceptibility mice SARS-CoV-2 infection was considered in several ways. Here, we generated a model expressing human ACE2 (hACE2) under control CAG promoter. Overexpression hACE2 did not pose significant effect on weight...
We used the secreted TSH receptor (TSHR) ectodomain variant TSHR-289 (truncated at amino acid residue 289 with a 6-histidine tail) to investigate properties of TSHR autoantibodies in Graves’ disease. Sequential concanavalin A and Ni-chelate chromatography extracted milligram quantities (∼20–40% purity) from culture medium. Nanogram this material neutralized binding inhibitory activity all 15 sera studied. generated mouse monoclonal antibody (mAb), 3BD10, partially purified TSHR-289....
Objectives: Evaluating children’s oral health status and treatment needs is challenging. We aim to build assessment toolkits predict Children’s Oral Health Status Index (COHSI) score referral for (RFTN) of health. Parent Child consist short-form survey items (12 children 8 parents) with without demographic information (7 questions) the child’s need treatment. Methods: Data were collected from 12 dental practices in Los Angeles County 2015 2016. predicted COHSI RFTN using random Bootstrap...