Studies of fruit and vegetable consumption in relation to overall health are limited. We evaluated the relationship between intake incidence cardiovascular disease cancer deaths from other causes two prospective cohorts.A total 71 910 female participants Nurses' Health study 37,725 male Professionals' Follow-up Study who were free major chronic completed baseline semiquantitative food-frequency questionnaires 1984 1986, respectively. Dietary information was updated 1990, 1994 for women 1990...

To examine the association between birth weight and non-fatal adult cardiovascular disease while controlling for potential confounders such as socioeconomic group lifestyle.Retrospective self report of in an ongoing longitudinal cohort nurses followed up by postal questionnaire every two years.Nurses' health study, a 121700 women since 1976.Non-fatal disease, including myocardial infarction, coronary revascularisation, stroke.Among 70297 free at baseline who reported 1992 there were 1309...

We prospectively examined the incidence of coronary heart disease in relation to cigarette smoking a cohort 119,404 female nurses who were 30 55 years age 1976 and free diagnosed disease. During six follow-up, 65 women died fatal 242 had nonfatal myocardial infarction. The number cigarettes smoked per day was positively associated with risk (relative = 5.5 for greater than or equal 25 day), infarction 5.8), angina pectoris 2.6). Even 1 4 5 14 twofold three-fold increase Overall, accounted...

BACKGROUND: In animal studies, prolactin has been found to be important for mammary epithelial development and its administration shown consistently increase the rate of tumor formation. Previous epidemiologic studies breast cancer risk in postmenopausal women have limited size, results inconsistent. We conducted a nested case-control study within prospective Nurses' Health Study cohort better determine relationship between plasma levels risk. METHODS: Blood samples were collected from...

It is known that cigarette smoking associated with increased risk of both thrombotic and hemorrhagic stroke among men. To test for such an association women, we examined the incidence in relation to a prospective cohort study 118,539 women 30 55 years age free from coronary heart disease, stroke, cancer 1976. During eight follow-up (908,447 person-years), identified 274 strokes, comprising 71 subarachnoid hemorrhages, 26 intracerebral 122 thromboembolic strokes about which information was...

Few studies that investigated the associations between breast density and subsequent cancer according to tumor characteristics have produced inconclusive findings. We aimed determine whether varied by characteristics. included 1042 postmenopausal women diagnosed with June 1, 1989, 30, 2004, 1794 matched control subjects from Nurses' Health Study, an ongoing prospective cohort study of 121 701 registered female nurses across United States. Breast was estimated digitized images using...

Abstract In current clinical practice, genetic testing to detect Lynch syndrome mutations ideally begins with diagnostic of an individual affected cancer before offering predictive at-risk relatives. An alternative strategy that warrants exploration involves screening unaffected individuals via demographic and family histories, those whose risks for carrying a mutation exceed selected threshold. Whether this approach would improve health outcomes in manner is cost-effective relative...

Physical activity has been consistently associated with lower risk of postmenopausal breast cancer, but its relationship premenopausal cancer is unclear. We investigated whether physical reduced incidence and, if so, what age period and intensity are critical. A total 64 777 women in the Nurses' Health Study II reported, starting on 1997 questionnaire, their leisure-time from 12 to current age. Cox regression models were used examine between activity, categorized by (adolescence, adulthood,...

Whether snoring increases the risk of hypertension remains unclear. The authors examined association between and in a cohort 73,231 US female nurses aged 40-65 years without diagnosed cardiovascular disease or cancer 1986. Blood pressure levels physician-diagnosed were self-reported through validated questionnaires. During 8 follow-up, 7,622 incident cases reported. Older age, smoking, body mass index, waist circumference, waist-hip ratio, weight gain, less physical activity, sleeping on...

In 1976, 118,273 female nurses 30–55 years of age with no history cancer completed a questionnaire regarding possible risk factors. By 1986, after 1,137,415 person-years follow-up, we had documented 1,799 newly diagnosed cases breast cancer. Compared the for nonusers oral contraceptives, multivariate relative risks were 1.07 (95% confidence interval, 0.97–1.19) all users, 1.06 0.96–1.18) past and 1.53 1.06–2.19) current users—women who used contraceptives up to 2 before diagnosis We conclude...

BackgroundThe impact of a new class automated digital patient engagement (DPE) platforms on potentially avoidable costs, hospital admissions, and complications after discharge following hip knee arthroplasties has not been established.MethodsWe conducted multicenter observational cohort study comparing claims data for 90 days at 10 practice sites in CA NV. One hundred eighty-six patients, enrolled between 2014 2016 an DPE platform receiving guidance remote monitoring perioperatively, were...

Background Over the last 10-15 years, US health care and practice of medicine itself have been transformed by a proliferation digital therapeutic products (collectively, tools [DHTs]). While number DHT classifications proposed to help organize these for discovery, retrieval, comparison organizations seeking potentially implement them, none specifically addressed that considering their implementation approach discovery process with one or more specific outcomes in mind. An outcomes-based...

The 4Ms Framework is the foundation of Age-Friendly Health System (AFHS) movement. While framework based on standalone evidence for each M, there limited about impact outcomes when practiced as a set. A composite measure capturing adherence to many care processes that comprise necessary but complex component closing gap. We offer navigation guide addresses key considerations developing hospital-based care. Institute Healthcare Improvement operationalizes minimum set Assessment and Act On...

The Age-Friendly Health System (AFHS) movement was conceptualized as a transformative solution to reliably deliver evidence-based care older adults. Guided by the 4Ms framework: What Matters, Mobility, Mentation, and Medication, AFHS healthcare systems have been given flexibility tailor interventions processes their context, preferences populations. This has facilitated widespread adoption of care. However, our understanding implementation grows, evidence impact on outcomes must keep up with...

The authors prospectively examined the association between bowel movement frequency, laxative use, and risk of colorectal cancer in 84, 577 women Nurses' Health Study living United States, 36–61 years age free 1982. Between 1984 1996, 611 incident cases were documented. After controlling for age, body mass index, fiber intake, postmenopausal status hormone physical activity, use laxatives, relative risks associated with having movements every third day or less, compared those once daily,...

Fasting plasma triglyceride, cholesterol and high-density lipoprotein (HDL) levels were studied for 190 white women, ages 21--39 years, who classified according to their oral contraceptive (OC) usage patterns at two community surveys, 3 years apart. The mean level of fasting triglyceride was higher among current OC users (95 mg/100 ml) than nonusers (73 (p = 0.002). After adjustment the possible confounding effects age, weight, cigarette smoking glucose level, still had a 19 ml that 0.007)....