A5038027473- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Drug-Induced Hepatotoxicity and Protection
- Acute Kidney Injury Research
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- Viral Infections and Immunology Research
- Moyamoya disease diagnosis and treatment
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Pharmacological Effects of Natural Compounds
- Neurological and metabolic disorders
- Vascular Malformations Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- CAR-T cell therapy research
- Electrolyte and hormonal disorders
- Heavy Metal Exposure and Toxicity
- Intracerebral and Subarachnoid Hemorrhage Research
- Antibiotics Pharmacokinetics and Efficacy
- RNA modifications and cancer
National Institutes for Food and Drug Control
2011-2024
Sun Yat-sen University
2022-2024
Nanchang University
2017-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2022-2024
First Affiliated Hospital of Jiangxi Medical College
2024
First Affiliated Hospital of Nanchang University
2017-2023
Guangdong Academy of Medical Sciences
2020-2022
Guangdong Provincial People's Hospital
2020-2022
Jiangsu Agri-animal Husbandry Vocational College
2021
Northwest A&F University
2016
Drug-induced liver injury (DILI) is one of the major concerns during drug development. Wide acceptance 3 R principles and innovation in-vitro techniques have introduced various novel model options, among which three-dimensional (3D) cell spheroid cultures shown a promising prospect in DILI prediction. The present study developed 3D quadruple co-culture for prediction via self-assembly. Induction by phorbol 12-myristate 13-acetate at concentration 15.42 ng/mL 48 hours with following 24-hour...
Abstract A microfluidic multi-organ chip emulates the tissue culture microenvironment, enables interconnection of organ equivalents and overcomes interspecies differences, making this technology a promising powerful tool for preclinical drug screening. In study, we established chip-based model that enabled non-contact cocultivation liver spheroids renal proximal tubule barriers in connecting media circuit over 16 days. Meanwhile, 14-day repeated-dose systemic administration cyclosporine...
Abstract High serum glucose to potassium ratio (GPR) at admission is implicated for a poor outcome in acute brain injury, intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. However, the relationship between GPR of ischemic stroke (IS) remains unknown. In all, 784 IS patients from large emergency Norwegian cohort were included secondary analysis. The exposure baseline all-cause mortality within 30 days after first admission. Multivariable logistic regression analysis was...
Objectives: Long noncoding RNAs (lncRNAs) play substantial roles in cerebral ischemia. Growth arrest-specific 5 (GAS5) was reported to be involved stroke. In the present study, we aimed investigate of GAS5 condition and unveil underlying mechanism.Method: Transient focal ischemia induced by intraluminal occlusion right Middle artery (MCAO) 2,3,5-triphenyltetrazolium chloride (TTC) staining used evaluate volume infarction. RT-qPCR applied level miR-221. Fluorescence activated Cell Sorting...
Oncolytic virotherapy is a new and safe therapeutic strategy based on the inherent cytotoxicity of oncolytic viruses their ability to replicate spread within tumors in selective manner. In previous study, type herpes simplex virus 2 (oHSV-2, named OH2) was constructed treat human cancers. That study demonstrated that OH2 genetically biologically stable. Its antitumor activity maintained, even after passaging for >20 generations. To advance into clinical trial, systematic preclinical safety...
The HK-2 cell model based on clusterin, osteopontin, CysC and KIM-1 would allow the prediction of nephrotoxicity at early stages.
MicroRNAs (miRNAs) present in tissues and biofluids are emerging as sensitive specific safety biomarkers. MiRNAs have not been thoroughly described M. fascicularis, an animal model used pharmaceutical industry especially drug evaluation. Here we investigated the miRNAs fascicularis. For Macaca mulatta, a closely related species of 619 stem-loop precursor (pre-miRNAs) 914 mature available miRBase version 21. Using mulatta reference list homology search tools, identified 604 pre-miRNAs 913...
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Maternal sodium butyrate (SB) intake has important effects on offspring growth and development. This study aimed to investigate the impacts of maternal SB supplementation during gestation lactation fatty acid composition lipid metabolism in skeletal muscle pigs. Twenty sows (Yorkshire, parity 2 3) were assigned control group (diets without SB, n = 10) with 0.1% 10). The results showed throughout increased (P < 0.05) body weight piglets at weaning. concentrations triglyceride plasma milk...
Abstract There have been intensive efforts to identify in vivo biomarkers that can be used monitor drug-induced kidney damage before significant impairment occurs. Kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, clusterin, β2-microglobulin and cystatin C (CysC) validated as clinical or preclinical urinary plasma predictive of acute chronic injuries diseases. A high-throughput vitro assay nephrotoxicity could potentially implemented early drug discovery stage reduce...
Background Disturbed serum calcium levels are related to the risk of stroke. However, previous studies exploring correlation between and clinical outcome ischemic stroke (IS) have shown inconsistent results. Object The study aimed investigate relationship admission 30-day mortality in patients with IS. Methods A total 876 IS from a Norwegian retrospective cohort were included for secondary analysis. exposure variable primary albumin-corrected (ACSC) at baseline all-cause within 30 days after...
Recombinant adeno-associated virus (rAAV) 2 vector gene therapy offers promise for the healing of Rheumatoid arthritis. To support clinical development candidate therapeutic product in China, a comprehensive preclinical safety assessment rAAV2 encoding human TNF receptor-immunoglobulin Fc fusion (rAAV2/human TNFR:Fc), were conducted 3 species experimental animals. No abnormal findings observed mice following single intravenous administration with test article. Compared control group, no...
Left ventricular (LV) extracellular remodeling is a critical process in aortic stenosis (AS), which related to functional abnormalities. Data regarding the use of combined T1 mapping and feature tracking (FT) assess LV severe AS are scarce. This study aimed investigate ability T1-derived FT-derived parameters identify changes patients with AS.A total 49 20 healthy volunteers were prospectively recruited. Modified look-locker inversion-recovery FT imaging performed all participants using...
The present study was performed to evaluate the food safety of TT51-1, a new type genetically modified rice that expresses Cry1Ab/Ac protein (Bt toxin) and is highly resistant most lepidopteran pests. Sixteen male 16 female cynomolgus monkeys were randomly divided into four groups: conventional (non-genetically rice, non-GM rice), positive control, 17.5% (GM rice) 70% GM rice. Monkeys in groups fed on diets containing or respectively, for 182 days, whereas animals group intravenously...
A comprehensive assessment of left ventricular (LV) remodeling and systolic function using contrast-enhanced cardiac magnetic resonance (CMR) imaging in patients with obstructive sleep apnea (OSA) has not yet been reported. This retrospective case-control study aimed to explore assess the myocardial structure, function, tissue characteristic changes LV OSA CMR method.Fifty-one selected participants 32 19 non-OSA underwent overnight polysomnography examination T1 mapping feature tracking...
Silent MR angiography (silent MRA) is a new generation of non-contrast enhanced with outstanding advantages in visualizing cerebrovascular lesions and the follow-up after endovascular treatment for intracranial aneurysms (IAs). This study aims to investigate reliability silent MRA-based three-dimensional (3D) geometric description hemodynamic calculation IAs.19 patients 23 unruptured IAs, who underwent both MRA 3D rotational (3DRA), were included this study. Computational fluid dynamics...