A5108051231- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Artificial Intelligence in Healthcare and Education
- Ferroptosis and cancer prognosis
- Thyroid and Parathyroid Surgery
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Head and Neck Anomalies
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Bioinformatics and Genomic Networks
- Neuroendocrine Tumor Research Advances
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Wnt/β-catenin signaling in development and cancer
- Radiation Dose and Imaging
- Clusterin in disease pathology
- Tumors and Oncological Cases
Fudan University Shanghai Cancer Center
2015-2024
Shanghai Medical College of Fudan University
2015-2024
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2024
First Affiliated Hospital of Anhui Medical University
2015-2023
Anhui Medical University
2015-2023
Sichuan Agricultural University
2022-2023
Nanjing Medical University
2023
Southern Medical University Shenzhen Hospital
2023
Stomatology Hospital
2023
Neoantigens induced by random mutations and specific to an individual's cancer are the most important tumor antigens recognized T cells. Among immunologically "cold" tumors, limited recognition of neoantigens results in absence a de novo antitumor immune response. These tumors present clinical challenge as they poorly responsive immunotherapies, including checkpoint inhibitors (ICIs). Radiation therapy (RT) can enhance resulting more diversified T-cell response, yet RT alone rarely systemic...
Although papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains core concern in the clinic. Molecular factors contributing to different risks (RRs) remain poorly defined. Here, we perform an integrative proteogenomic metabolomic characterization of 102 Chinese PTC patients with RRs. Genomic profiling reveals that mutations MUC16 TERT promoter as well multiple gene fusions like NCOA4-RET are enriched by RR. Integrative multi-omics analyses further...
// Tian Liao 1, * , Ning Qu Rong-Liang Shi 2, Kai Guo 1 Ben Ma Yi-Ming Cao Jun Xiang Zhong-Wu Lu Yong-Xue Zhu Duan-Shu Li Qing-Hai Ji Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Oncology, Medical College, University, Shanghai, 200032, China 2 General Minhang Hospital, 201199, These authors contributed equally to this work Correspondence to: JI, email: jiqinghai@shca.org.cn Keywords: papillary thyroid cancer, BRAF, lncRNA, proliferation, migration Received:...
The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine clinical significance HNSCC. Using vitro vivo assays, we show that overexpression suppressed apoptosis, promoted proliferation, migration, invasion, cycle arrest at G1/S transition. By contrast, silencing inhibited these activities. further upregulated phosphorylation AKT enhanced...
Background: Recently, thermal ablation has been proposed for treating primary papillary thyroid carcinoma (PTC), triggering an extensive debate. This study aimed to analyze surgical outcomes of post-ablation cases investigate the effectiveness and safety in PTC. Methods: Primary PTC patients treated with were retrospectively searched from authors' medical record database prior August 2017. The met following criteria: (i) ablation, (ii) findings suspicious malignancy lesions on ultrasound or...
Abstract Context Programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte activation gene-3 (LAG-3), ITIM domain (TIGIT) are considered major immune co-inhibitory receptors (CIRs) the most promising immunotherapeutic targets in cancer treatment, but they largely unexplored medullary thyroid carcinoma (MTC). Objective We aimed to provide first evidence regarding expression profiles clinical...
Background: Surgery is the primary treatment for locally advanced thyroid cancer. For some cases, R0/R1 resection could not be achieved at initial diagnosis and neoadjuvant would an option. Anlotinib a multitarget tyrosine kinase inhibitor, which demonstrated antitumor activity in radioiodine-refractory differentiated cancer medullary We aimed to evaluate efficacy safety of anlotinib setting. Methods: This single-arm phase II study investigated (12 mg orally daily, 2 weeks on/1 week off) 2-6...
Abstract Context Metabolic reprogramming is a common feature of tumorigenesis. It remains unknown concerning the expression pattern metabolism-associated genes in dedifferentiated thyroid cancer (DDTC). Objective This study aimed to identify useful signature indicate dedifferentiation papillary (PTC). Design and Setting We used one discovery two validation cohorts screen out aberrant metabolic DDTC, further The Cancer Genome Atlas (TCGA) cohort search for independent risk factors...
Background and Objectives: Targeting cancer-associated fibroblast (CAF) is being explored as an approach to improve cancer therapies. The roles of CAF remain unclarified in malignant transformation papillary thyroid (PTC) into dedifferentiated (DDTC). This study aimed investigate correlations with dedifferentiation clinicopathological characteristics cancer. Materials Methods: We applied three different mRNA-based gene signatures quantify our cohort, the Gene Expression Omnibus (GEO) cohort...
Abstract A number of long non-coding RNAs (lncRNAs) have been found to play critical roles in oncogenesis and tumor progression. We aimed investigate whether lncRNAs could act as prognostic biomarkers for papillary thyroid cancer (PTC) that may assist us evaluating disease status prognosis patients. 220 with expression alteration from the annotated 2773 approved by HUGO gene nomenclature committee The Cancer Genome Atlas (TCGA) dataset, which FAM41C, CTBP1-AS2, LINC00271, HAR1A, LINC00310...
Purpose The purpose of this paper is to explore consumers’ intention purchase genetically modified (GM) food from the perspective risk information. Design/methodology/approach A conceptual model was proposed in which GM stimulated by combination and complex effects knowledge, perception, information need, seeking attitude. face-to-face questionnaire survey conducted Jinan, Shandong Province. total 757 valid samples (55.6 percent women vs men) were involved conduct structural equation...
Background: Expression of the programmed death-ligand 1 (PD-L1) in medullary thyroid carcinoma (MTC) has been rarely reported. In this study, we evaluated PD-L1 positivity MTC and analyzed its correlation with clinicopathological characteristics, structural recurrence (SR), biochemical recurrence/persistent disease (BcR/BcPD). We also prevalence expression patients developing distant or unresectable locoregional recurrence. Methods: total, 201 consecutive who underwent initial surgery our...
// Tian Liao 1, * , Duo Wen Ben Ma Jia-Qian Hu 1 Ning Qu Rong-Liang Shi Liang Liu 2 Qing Guan Duan-Shu Li Qing-Hai Ji Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Oncology, Medical College, University, 200032, China Breast Institute, Shanghai, These authors have contributed equally to this work Correspondence to: Ji, email: ji_qh2015@163.com Keywords: papillary thyroid cancer, YAP1, proliferation, signaling pathway Received: June 08, 2016 Accepted: December...
Lipid metabolism plays important roles not only in the structural basis and energy supply of healthy cells but also oncogenesis progression cancers. In this study, we investigated prognostic value lipid metabolism-related genes papillary thyroid cancer (PTC). The recurrence predictive gene signature was developed internally externally validated based on PTC datasets including Cancer Genome Atlas (TCGA) GSE33630 datasets. Univariate, LASSO, multivariate Cox regression analysis were applied to...
Patients with advanced thyroid carcinoma (TC), such as anaplastic (ATC), poorly differentiated (PDTC), and locally papillary (PTC), have poor prognoses require novel treatments. Immune checkpoint (ICP) inhibitors demonstrated encouraging good results; nevertheless, their effect in TCs remains largely unclear. Thus, we ICP profiles investigated potential clinical significance.A total of 234 TC patients were involved, 22 ATCs, 44 PDTCs, 168 PTCs, including 58 PTCs. Immunohistochemistry was...
Abstract The incidence of PTMC has been increasing in the recent years. This study aimed to investigate diagnostic value US ‐ FNA thyroid nodules ≤1 cm and whether presence Hashimoto's thyroiditis ( HT ) could influence accuracy. patients who accepted at FUSCC from December 2012 November 2015 followed our criteria were enrolled this study. We extracted cytological, pathological, follow‐up / data with subcentimeter nodules. Sensitivity, specificity, positive predictive PPV ), negative NPV...
<p>Deep learning radiomic feature selection and the establishment of DLRI using LASSO logistic regression model.</p>
<p>The overall workflow of the Deep Learning Radiomics signature Inflammatory (DLRI).</p>