A5062357176- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Pancreatic function and diabetes
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
Dalian Institute of Chemical Physics
2022-2024
Chinese Academy of Sciences
2022-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Shenzhen Institutes of Advanced Technology
2023
HKUST Shenzhen Research Institute
2023
The activity of 5'-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability glucose. When glucose levels are low, glycolytic enzyme aldolase not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals activate lysosomal AMPK. Here, we show that blocking FBP binding small molecule aldometanib selectively activates pool AMPK and has beneficial metabolic effects in rodents. We identify a screen for inhibitors it prevents from...
Although papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains core concern in the clinic. Molecular factors contributing to different risks (RRs) remain poorly defined. Here, we perform an integrative proteogenomic metabolomic characterization of 102 Chinese PTC patients with RRs. Genomic profiling reveals that mutations MUC16 TERT promoter as well multiple gene fusions like NCOA4-RET are enriched by RR. Integrative multi-omics analyses further...
Abstract Early detection is warranted to improve prognosis of gastric cancer (GC) but remains challenging. Liquid biopsy combined with machine learning will provide new insights into diagnostic strategies GC. Lipid metabolism reprogramming plays a crucial role in the initiation and development tumors. Here, we integrated lipidomics data three cohorts ( n = 944) develop lipid metabolic landscape We further constructed serum signature (SLMS) by learning, which showed great performance...
Abstract Although papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains core concern in the clinic. Molecular factors contributing to different risks (RRs) remain poorly defined. Here, we performed an integrative proteogenomic metabolomic characterization of 102 Chinese PTC patients with RRs. Genomic profiling revealed that mutations MUC16 TERT promoter as well multiple gene fusions like NCOA4 - RET were enriched by RR. Integrative multi-omics analysis...
Abstract Pyruvate is an essential fuel for maintaining the tricarboxylic acid (TCA) cycle in mitochondria. However, precise molecular mechanism of pyruvate uptake by mitochondrial carrier (MPC) largely unknown. Here, we report that DNA/RNA-binding protein Y-box binding 1 (YBX1) localized to inter-membrane space its C-terminal domain (CTD) cancer cells. In mitochondria, YBX1 inhibits associating with MPC1/2, thereby suppressing pyruvate-dependent TCA flux. This association, turn, promotes...
Abstract N 6 -methyladenosine (m A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m A their impact on protein synthesis machinery remain unclear. VIRMA, largest evolutionarily conserved core methyltransferase complex, is highly expressed embryonic brain various cancers. Here, we demonstrate that VIRMA-mediated essential for active ribosome biogenesis. VIRMA depletion destabilizes entire writer complex reduces...