A5108037567- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- RNA modifications and cancer
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Bioactive Natural Diterpenoids Research
- Circular RNAs in diseases
- Ear and Head Tumors
- Cancer-related Molecular Pathways
- Glutathione Transferases and Polymorphisms
- Oral and Maxillofacial Pathology
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Biomarkers in Disease Mechanisms
- Genetic Associations and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Traditional and Medicinal Uses of Annonaceae
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Bioactive Compounds
- Plant-derived Lignans Synthesis and Bioactivity
Fudan University Shanghai Cancer Center
2014-2025
Shanghai Medical College of Fudan University
2013-2024
Institute of Modern Physics
2018-2022
University of Chinese Academy of Sciences
2022
First Affiliated Hospital of Henan University
2022
Arizona State University
2022
Lanzhou University
2015-2020
Chinese Academy of Sciences
2012-2018
Fudan University
2014-2015
Guangdong Medical College
2015
Context:The surgical management of papillary thyroid microcarcinoma (PTMC), especially regarding the necessity central lymph node dissection, remains controversial.
A woman in her early 60s with hypertension and hyperlipidemia was undergoing investigations for anemia of unknown etiology. She developed a sudden reduction visual acuity bilateral field impairment. MRI angiography revealed acute infarcts the posterior circulation severe narrowing left vertebral artery origin. Digital subtraction demonstrated high-grade stenosis origin thrombus just distal to stenosis. The patient recurrent while on antithrombotic therapy. lesion successfully treated by...
Medullary thyroid cancer (MTC) is a rare malignancy, with 70% to 80% of cases being sporadic (sMTC). Current guidelines recommend total thyroidectomy (TT) for all preoperatively suspicious sMTC, though there has been increasing support reducing the surgical extent in recent years. However, relevant data are limited. This study aimed comprehensively evaluate safety hemithyroidectomy (HT) sMTC. included 797 patients MTC who received curative-intent initial surgery at 19 participating referral...
Two new triterpenoids, spirochensilides A (1) and B (2) were isolated from Abies chensiensis. Comprehensive spectroscopic analysis revealed that 1 2 are the first example of triterpenoids possessing a unique 8,10-cyclo-9,10-seco methyl-rearranged carbon skeleton. The single crystal X-ray diffraction analyses computational methods allowed absolute configuration assignments two compounds. plausible biogenetic pathway spirochensilide is also proposed.
Background Rs2910164, a Single nucleotide polymorphism (SNP) located in the precursor microRNA sequence of miR-146a, is only MicroRNA SNP studied papillary thyroid cancer (PTC). Association studies had been performed US and UK-Northern European populations, but results were inconsistence. This study evaluated association between rs2910164 risk PTC as well benign tumor (BN), examined clinicopathological characteristics BN for different genotypes. Methods case-control genotyped 753 PTCs, 484...
(1) Background: The genetic predisposition to papillary thyroid cancer (PTC) is far from clearly elucidated. Rs2292832 a polymorphism that located in the precursor of mir-149 and has been studied diverse cancers. Thus far, role rs2292832 PTC tumorigenesis progression was unclear; (2) Method: genotyped 838 PTCs, 495 patients with benign tumors (BNs) 1006 controls Chinese Han population. Clinicopathological data collected compared. expression level mature examined 55 normal tissue samples; (3)...
Abstract Age has been included in various prognostic scoring systems for differentiated thyroid cancer (DTC). The aim of this study is to re-examine the relationship between age and prognosis by using Surveillance, Epidemiology, End Results (SEER) population-based database. We identified 51,061 DTC patients 2004 2012. Patients were separated into 10-year groups. Cancer cause-specific survival (CSS) overall (OS) data obtained. Kaplan-Meier multivariable Cox models built analyze outcomes risk...
Anaplastic thyroid cancer (ATC) responds poorly to conventional therapies and requires a multidisciplinary approach manage. The aim of the current study is explore whether aggressive treatment beneficial, especially appropriate extent surgery in ATC. Patients diagnosed with ATC from 2004 2014 were identified Surveillance, Epidemiology, End Results (SEER) database included our study. A total 735 patients identified. two-year overall survival (OS) rates for stage IVA, IVB, IVC 36.5%, 15.6%,...
Abstract Background Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast (BC) survivors. Materials and methods A retrospective study was conducted BC patients our center from 1999 to 2013. Patients were divided into BC‐TC group BC‐alone group. Results In total, 13 978 identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) TC 4.48 compared with Chinese females, up 98.0% cases thyroid papillary carcinomas. family history only independent...
Abstract The incidence of thyroid cancer has increased worldwide at a rate higher than that any other cancer. CSN 6 is overexpressed in many types cancers, and such expression linked to oncogenic activity. However, the detailed biological functions papillary ( PTC ) have not been well characterized. We investigated specimens cell lines. used short‐hairpin RNA ‐mediated gene silencing explore effects depletion cells. combined FH 535 therapy were assessed terms viability. mechanism by which...
Six new (1–3 and 6–8) seven known diterpenoids were isolated from the whole plant of Ligularia fischeri. Compound 1 is a 15,16-dinorerythroxylane-type diterpenoid possessing C18 skeleton, 2 first example 6/6/6/6/5/5-fused hexacyclic ent-kaurane with 19,20-olide 11,16-epoxy moieties. The structures compounds elucidated by spectroscopic analysis chemical methods. absolute configurations 7 determined single-crystal X-ray diffraction. Compounds 1–13 evaluated for their immunosuppressive...
Thirteen new ent-isopimarane-type diterpenoids, 1-10 and 14-16, seven known 11-13 17-20, were isolated from the roots of Euphorbia hylonoma. Among these compounds, four pairs C-12 epimers (1 vs 2, 4 5, 12 13, 14 15) identified. The structures diterpenoids elucidated using spectroscopic data analyses, electronic circular dichroism, single-crystal X-ray diffraction data. phytotoxic effects compounds 1-20 on growth shoots Poa annua Festuca arundinacea seedlings evaluated. tested 18 was most...
The incidence of coexisting papillary thyroid cancer (PTC) and Hashimoto's thyroiditis (HT) is increasing. impact HT on PTC prognosis its possible mechanism remains controversial. Interleukin-17A (IL-17A) has been reported to participate in the pathogenesis multiple autoimmune diseases cancers. aim this study investigate role IL-17A with coexistent evaluate changes tumor antigenicity. Expression major histocompatibility complex (MHC) class I molecules were compared tissue samples or without...
Thyroid cancer is a common endocrine cancer, of which papillary thyroid (PTC) the most type. Neuregulin 1 (NRG1), glycoprotein mediating cell‑cell signaling, plays vital roles in cellular activities; however, its role PTC progression remains poorly understood. In this study, we performed immunohistochemistry 196 samples from patients and found that NRG1, potential prognostic marker highly expressed compared with adjacent normal tissues. Cell Counting kit‑8 (CCK‑8) clone formation assays...
Purpose: The prognostic value of primary tumor surgery (PTS) in minor salivary-gland carcinoma (MiSGC) with distant metastasis (DM) at diagnosis has never been investigated. In this study, we aimed to provide the first evidence. Patients and methods: Surveillance, Epidemiology, End Results (SEER) database was employed identify MiSGC patients DM diagnosis. PTS evaluated by Kaplan–Meier methods, log-rank analyses, multivariate Cox proportional-hazard regression models. Results: Of 152 eligible...
Patients with anaplastic thyroid cancer (ATC), which is among the deadliest of all cancers, often have a poor response to traditional therapies. Currently, role long non-coding RNAs (lncRNAs) in ATC carcinogenesis unclear. In this study, we analyzed lncRNA expression profile aim identifying potential molecular targets for treatment disease.Whole transcriptome sequencing three and two normal (NT) samples was performed, analyzed. Original data as well datasets deposited Gene Expression Omnibus...