A5061356939- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Virus-based gene therapy research
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Nanowire Synthesis and Applications
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Jilin Province Tumor Hospital
2024
Fudan University Shanghai Cancer Center
2021-2023
Shaanxi University of Chinese Medicine
2023
Shanghai Medical College of Fudan University
2021-2022
Lipid metabolism plays important roles not only in the structural basis and energy supply of healthy cells but also oncogenesis progression cancers. In this study, we investigated prognostic value lipid metabolism-related genes papillary thyroid cancer (PTC). The recurrence predictive gene signature was developed internally externally validated based on PTC datasets including Cancer Genome Atlas (TCGA) GSE33630 datasets. Univariate, LASSO, multivariate Cox regression analysis were applied to...
Abstract Purpose: Medullary thyroid carcinoma (MTC) presents a distinct biological context from other cancers due to its specific cellular origin. This heterogeneous and rare tumor has high prevalence of advanced diseases, making it crucial address the limited therapeutic options enhance complex clinical management. Given accessibility methylation information, we construct largest MTC cohort date. Experimental Design: Seventy-eight fresh-frozen samples constituted our cohort. The...
Abstract Context Hypoxia is commonly observed in multiple aggressive cancers. Its role remains unclear the biology and therapy of dedifferentiated thyroid cancer (DDTC). Objective We aimed to elucidate hypoxia's roles DDTC tumor biology. Methods discovered confirmed correlation with dedifferentiation status, poor prognoses, immune checkpoints using transcriptome data from our center Gene Expression Omnibus (GEO) database. Then, effect targeting hypoxia was investigated via treating...
<p>Supplementary Methods</p>
<div>AbstractPurpose:<p>Medullary thyroid carcinoma (MTC) presents a distinct biological context from other cancers due to its specific cellular origin. This heterogeneous and rare tumor has high prevalence of advanced diseases, making it crucial address the limited therapeutic options enhance complex clinical management. Given accessibility methylation information, we construct largest MTC cohort date.</p>Experimental Design:<p>Seventy-eight fresh-frozen samples...
<p>List of top 30 differentially methylated regions (DMRs) MTC-C relative to the other two subtypes</p>
<p>Classification and prediction effects of methylation-based MTC clustering system</p>
<p>Classification and prediction effects of methylation-based MTC clustering system</p>
<p>Detailed methylation profile of DMR associated with NNAT</p>
<p>List of top 30 differentially methylated regions (DMRs) MTC-C relative to the other two subtypes</p>
<p>Detailed methylation profile of DMR associated with NNAT</p>
<p>Hyperparameter optimization of elastic net mixing parameter (alpha) in the machine learning model</p>
<p>Hyperparameter optimization of elastic net mixing parameter (alpha) in the machine learning model</p>
<p>Detailed patient information of the MTC methylation cohort</p>
<p>Supplementary Methods</p>
<p>Detailed patient information of the MTC methylation cohort</p>
<div>AbstractPurpose:<p>Medullary thyroid carcinoma (MTC) presents a distinct biological context from other cancers due to its specific cellular origin. This heterogeneous and rare tumor has high prevalence of advanced diseases, making it crucial address the limited therapeutic options enhance complex clinical management. Given accessibility methylation information, we construct largest MTC cohort date.</p>Experimental Design:<p>Seventy-eight fresh-frozen samples...
BackgroundPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are associated with drug resistance and prognosis in lung cancer; however, the consistency clinical value of PIK3CA between tissue liquid samples unknown.MethodsCirculating tumor DNA (ctDNA) matched from 405 advanced cancer patients were collected at Jilin Cancer Hospital 2018 2022, mutation status was sequenced using next-generation sequencing based on a 520 gene panel. The viability...
Viral invasion of the body causes metabolic changes involving pathways such as gluconeogenesis, amino acid metabolism, lipid TCA cycle, and energy metabolism affects vital bodily processes nucleic acid, protein, synthesis. During antiviral therapy, immune response is closely related to balance, numerous metabolites, including glycolytic acids, nucleotides, can influence response. Monitoring metabolites by metabolomics technology aid in continuously optimizing efficacy medications used treat...