A5074917828- Biosimilars and Bioanalytical Methods
- Clinical Laboratory Practices and Quality Control
- Antibiotics Pharmacokinetics and Efficacy
- Malaria Research and Control
- Protein purification and stability
- Trypanosoma species research and implications
- Hormonal Regulation and Hypertension
- Biosensors and Analytical Detection
- Eicosanoids and Hypertension Pharmacology
- Heavy Metal Exposure and Toxicity
- Chronic Kidney Disease and Diabetes
- Pharmacogenetics and Drug Metabolism
- Cholesterol and Lipid Metabolism
- HIV/AIDS drug development and treatment
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Bioactive Compounds
- Estrogen and related hormone effects
- Ferrocene Chemistry and Applications
- Proteoglycans and glycosaminoglycans research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects of Natural Compounds
- Epilepsy research and treatment
- Cancer, Hypoxia, and Metabolism
Sanofi (France)
2004-2016
Université de Bourgogne
1991-2013
Sanofi (Mexico)
2011
Ferroquine (SSR97193), a ferrocene-quinoline conjugate, is promising novel antimalarial currently undergoing clinical evaluation. This study characterizes its pharmacokinetic properties. Young male African volunteers with asymptomatic Plasmodium falciparum infection were administered single oral dose (n = 40) or repeated 26) given over 3 days of ferroquine in two dose-escalation, double-blind, randomized, placebo-controlled trials. In addition, food interaction was performed subsample...
Teriflunomide, a once-daily oral immunomodulator approved for treatment of relapsing-remitting multiple sclerosis, is eliminated slowly from plasma. If necessary to rapidly lower plasma concentrations teriflunomide, an accelerated elimination procedure using cholestyramine or activated charcoal may be used. The current bioanalytical assay determination teriflunomide concentration requires laboratory facilities blood centrifugation and storage. An alternative method, with potential greater...
Abstract Thiocolchicoside (TCC) has been prescribed for several years as a muscle relaxant drug, but its pharmacokinetic (PK) profile and metabolism still remain largely unknown. Therefore, we re‐investigated PK, assessed the properties of metabolites. After oral administration 8 mg (a therapeutic dose) 14 C‐labelled TCC to healthy volunteers, found no detectable in plasma, urine or faeces. On other hand, aglycone derivative obtained after de‐glycosylation (M2) was observed and, addition,...
To assess the effect of food on pharmacokinetics anti-malarial amodiaquine (AQ, CAS 6398-98-7) and artesunate (AS, 182824-33-5) their active metabolites [desethylamodia-quine (DSA][CAS 81496-81-3) dihy-droartemisinin (DHA][CAS79352-78-6)][respectively] in healthy volunteers. In an open, two-way crossover study, 22 male volunteers fasted overnight were randomised to receive a single oral administration 4 tablets fixed-dose combination containing 135 mg AQ 50 AS absence or presence...
Characterization of glycosaminoglycans poses a challenge for current analytical techniques, as they are highly acidic, polydisperse and heterogeneous compounds. The purpose this study is the separation analysis partially depolymerized heparin-like glycosaminoglycan by on-line ion-pairing reversed-phase high-performance liquid chromatography/electrospray mass spectrometry. gas-phase behavior two synthesized has been investigated. Dibutylamine was found to be best suited reagents spectrometry...
Fexinidazole (FEX) is a nitroimidazole being developed as new trypanocide treatment for human African trypanosomiasis/sleeping sickness. Its main metabolites, fexinidazole sulfoxide (M1) and sulfone (M2), show the same in vitro pharmacological activity FEX.An LC-MS/MS assay was quantitation of FEX DBS, collected via finger-prick from healthy subjects. The DBS specific, accurate reproducible FEX, M1 M2 when validated against current plasma assay. samples were stable 24 h at 37°C with 95%...