A5078745995- Traumatic Brain Injury Research
- Automotive and Human Injury Biomechanics
- Injury Epidemiology and Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Sports injuries and prevention
- Cardiac Arrest and Resuscitation
- Winter Sports Injuries and Performance
- Traumatic Ocular and Foreign Body Injuries
- Hepatocellular Carcinoma Treatment and Prognosis
- Elasticity and Material Modeling
- Colorectal Cancer Treatments and Studies
- EEG and Brain-Computer Interfaces
- Ultrasound Imaging and Elastography
- Radiomics and Machine Learning in Medical Imaging
- Dental Trauma and Treatments
- Medical Imaging and Analysis
- Retinal and Optic Conditions
- Gaze Tracking and Assistive Technology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Autopsy Techniques and Outcomes
- Intraocular Surgery and Lenses
- Microfluidic and Capillary Electrophoresis Applications
- Spinal Cord Injury Research
- Medical Imaging Techniques and Applications
University of British Columbia
2018-2025
Wenzhou Hospital of Traditional Chinese Medicine
2025
Roche (China)
2023
Hospital Universitari Germans Trias i Pujol
2023
Stanford University
2013-2020
InferVision (China)
2020
Bioengineering Center
2019
Palo Alto University
2013
University of Toronto
2010
Universidad Hispanoamerica
2006
Abstract Background: The risk of HCC recurrence after liver resection or ablation with curative intent is 70-80% within 5 years, indicating an unmet need for effective adjuvant therapies. Atezolizumab (atezo) bevacizumab (bev) the standard care unresectable based on IMbrave150 study, which demonstrated statistically significant and clinically meaningful improvements in overall survival (OS), progression-free survival, objective response rate versus sorafenib (Finn NEJM 2020, Cheng J Hepatol...
Abstract Accumulation of head impacts may contribute to acute and long-term brain trauma. Wearable sensors can measure impact exposure, yet current do not have validated detection methods for accurate exposure monitoring. Here we demonstrate a method that be implemented on wearable sensor detecting field football impacts. Our incorporates support vector machine classifier uses biomechanical features from the time domain frequency domain, as well model predictions head-neck motions. The was...
Abstract Aim Food allergy is common in children and adults, could be potentially fatal minor groups. It important for physicians to identify the prevalence of food allergies recognise allergens make precise diagnosis choose correct therapeutic approaches. Methods We used a nationwide, cross‐sectional, random questionnaire‐based survey estimate self‐reported expert‐screened T aiwan. In this study, perceptional was screened by according descriptions convincing symptoms medical recordings;...
A simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS) is presented. coating of liquid PDMS applied on the walls rectangular microchannels, fabricated using standard soft-lithography, by introducing a pressurized air stream inside filled microchannels. Surface tension forces take cross-section which preserved baking device cure coated layer. Diameters ranging from few micrometres hundreds were achieved. The was verified work microchannel networks as well straight...
Previous research has sought to quantify head impact exposure using wearable kinematic sensors. However, many sensors suffer from poor accuracy in estimating kinematics and count, motivating the need for additional independent quantification comparison. Here, we equipped seven collegiate American football players with instrumented mouthguards, video recorded practices games compare video-based sensor-based rates location distributions. Over 50 player-hours, identified 271 helmet contact...
Although safety standards have reduced fatal head trauma due to single severe impacts, mild from repeated exposures may carry risks of long-term chronic changes in the brain's function and structure. To study physical sensitivities brain we developed first dynamic model skull-brain based on vivo MRI data. We showed that motion can be described by a rigid-body with constrained kinematics. further demonstrated dynamics approximated an under-damped system low-frequency resonance at around 15...
Injury from blunt head impacts causes acute neurological deficits and may lead to chronic neurodegeneration. A impact detection device can serve both as a research tool for studying injury mechanisms clinical real-time trauma screening. The simplest approach is an acceleration thresholding algorithm, which falsely detect high-acceleration spurious events such manual manipulation of the device. We designed system that distinguishes nonimpacts through two subsystems. First, we use infrared...
While many research efforts have focused on head impact exposure in professional soccer, there been few studies characterizing at the youth level. The aim of this study is to evaluate a new instrumentation approach and collect some first data for female soccer players. Athletes were instrumented with custom-fit mouthpieces that measure impacts. Detailed video analysis was conducted identify characteristics describing source (e.g., kick, header, throw). A total 763 verified impacts collected...
Given the worldwide adverse impact of traumatic brain injury (TBI) on human population, its diagnosis and prediction are utmost importance. Historically, many studies have focused associating head kinematics to risk. Recently, there has been a push toward using computationally expensive finite element (FE) models create tissue deformation metrics injury. Here, we develop new metric, angle metric (BAM), based dynamics 3 degree-of-freedom lumped parameter model. The model is built measured...
Wearable devices are increasingly used to measure real-world head impacts and study brain injury mechanisms. These must undergo validation testing ensure they provide reliable accurate information for impact sensing, controlled laboratory should be the first step of validation. Past studies have applied varying methodologies, some been deployed on-field use without This paper presents best practices recommendations validating wearable kinematic in laboratory, with goal standardizing test...
4002 Background: In IMbrave050, adjuvant atezo + bev demonstrated a statistically significant and clinically meaningful improvement in recurrence-free survival (RFS) vs active surveillance patients (pts) at high risk of HCC recurrence following resection or ablation with curative intent. Further, the safety was generally manageable. Here, we additionally report PRO data from IMbrave050. Methods: IMbrave050 (NCT04102098) enrolled pts ablation. Pts were randomized to Arm A (atezo bev) B...
Diagnosing psychiatric disorders following craniocerebral trauma primarily depends on clinical symptoms and neuropsychological evaluation, which can be subjective limited. This study aimed to investigate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9), S100 calcium-binding protein β (S100-β), glial fibrillary acidic (GFAP) in post-traumatic mental disorders. A retrospective analysis was conducted 108 patients with admitted Wenzhou Hospital Integrated Traditional Chinese...
With 300,000,000 riders annually, roller coasters are a popular recreational activity. Although the number of coaster injuries is relatively low, precise effect rides on our brains remains unknown. Here we present quantitative characterization brain displacements and deformations during rides. For two healthy adult male subjects, recorded head accelerations three representative rides, and, for comparison, running soccer headers. From recordings, simulated using rigid body dynamics finite...
Abstract Despite numerous research efforts, the precise mechanisms of concussion have yet to be fully uncovered. Clinical studies on high-risk populations, such as contact sports athletes, become more common and give insight link between impact severity brain injury risk through use wearable sensors neurological testing. However, number institutions operating these grows, there is a growing need for platform share data facilitate our understanding aid in development suitable diagnostic...