A5091830127- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Injury Epidemiology and Prevention
- Traffic and Road Safety
- Elasticity and Material Modeling
- Transportation Safety and Impact Analysis
- Sports injuries and prevention
- Fashion and Cultural Textiles
- Cerebrospinal fluid and hydrocephalus
- Winter Sports Injuries and Performance
- Advanced Neuroimaging Techniques and Applications
- Traumatic Ocular and Foreign Body Injuries
- Bone fractures and treatments
- Medical Imaging and Analysis
- Balance, Gait, and Falls Prevention
- Autopsy Techniques and Outcomes
- Cellular Mechanics and Interactions
- Restraint-Related Deaths
- Orthopaedic implants and arthroplasty
- Cardiac Arrest and Resuscitation
- Child Abuse and Related Trauma
- Hip disorders and treatments
- Bone health and osteoporosis research
- Trauma and Emergency Care Studies
KTH Royal Institute of Technology
2016-2025
University of Copenhagen
2023
Institut Teknologi PLN
2015
Google (United States)
2013
The aim of this study is to evaluate all the 58 available NFL cases and compare various predictors for mild traumatic brain injuries using a detailed extensively validated finite element model human head. Global injury measures such as magnitude in angular translational acceleration, change velocity, head impact power (HIP) HIC were also investigated with regard their ability predict intracranial pressure strains associated injury. material properties modeled hyperelastic viscoelastic...
A parameterized, or scalable, finite element (FE) model of the human head was developed and validated against available cadaver experiment data for three impact directions (frontal, occipital lateral). The brain material properties were modeled using a hyperelastic viscoelastic constitutive law. interface between skull in different ways ranging from purely tied (no-slip) to sliding (free-slip). Two contact definitions compared with condition. Also, stiffness parameters, encompassing range...
Finite element (FE) models are often used to study the biomechanical effects of traumatic brain injury (TBI). Measures based on mechanical responses, such as principal strain or invariants tensor, a metric predict risk injury. However, reliability inferences drawn from these depends correspondence between measures and data, well establishment accurate thresholds tissue In current study, validated anisotropic FE model human head is evaluate hypothesis that in direction fibers (axonal strain)...
The length scales involved in the development of diffuse axonal injury typically range from head level (i.e., mechanical loading) to cellular level. parts brain that are vulnerable this type mainly brainstem and corpus callosum, which regions with highly anisotropically oriented axons. Within these parts, discrete injuries occur where axons have deviate their main course due presence an inclusion. aim study is predict strains as a result load at macroscopic For this, multi-scale finite...
Finite element head (FE) models are important numerical tools to study injuries and develop protection systems. The generation of anatomically accurate subject-specific with conforming hexahedral meshes remains a significant challenge. focus this is present two developmental works: first, an detailed FE model that has smooth interfaces between the brain cerebrospinal fluid, embedded white matter (WM) fiber tracts; second, morphing approach for via new hierarchical image registration pipeline...
Abstract The integrity of cellular membranes is critical for the functionality axons. Failure axonal (plasma membrane and/or myelin sheath) can be origin neurological diseases. two differ in content sphingomyelin and galactosylceramide lipids. We investigate relation between lipid bilayer structural-mechanical properties, to better understand dependency properties on composition. A sphingomyelin/phospholipid/cholesterol used mimic a plasma galactosylceramide/phospholipid/cholesterol sheath....
Bicycle helmets are shown to offer protection against head injuries. Rating methods and test standards used evaluate different helmet designs safety performance. Both strain-based injury criteria obtained from finite element brain models metrics derived global kinematic responses can be Little is known about how or would rank rate helmets. The objective of this study was determine eight based on kinematics a large number bicycle (n=17) subjected oblique impacts. results showed that the...
The objective of the present study was to analyze effect different loading directions following impact, and evaluate existing global head injury criteria. Detailed parameterized models adult human were created by using Finite Element Method (FEM). Loads corresponding same impact power imposed in directions. Furthermore, Head Injury Criterion (HIC) recently proposed Impact Power (HIP) criterion evaluated with respect relative motion between skull brain, as well strain bridging veins. It found...
Multiple length scales are involved in the development of traumatic brain injury, where global mechanics head level responsible for local physiological impairment cells. In this study, a relation between mechanical state at tissue and cellular is established. A model has been developed that based on pathological observations axonal injury. The contains axons surrounding an obstacle (e.g., blood vessel or soma). axons, which described by anisotropic fiber-reinforced material model, have...
Concussion is an injury of specific interest in collision and contact sports, resulting a need to develop effective preventive strategies. A detailed finite element model the human head was used approximate regional distribution tissue deformations brain by simulating reconstructions unhelmeted concussion no-injury impacts. The results were evaluated using logistic regression analysis it found that angular kinematics, coronal plane, maximum principal strains, all regions brain, significantly...
Brain tissue modelling has been an active area of research for years. matter does not follow the constitutive relations common materials and loads applied to brain turn into stresses strains depending on local morphology. In this work, a hyperviscoelastic fibre-reinforced anisotropic law is used computational injury prediction. Thanks fibre-reinforcement dispersion parameter, formulation accounts features heterogeneities owing different axon alignment. The novelty work correlation material...
Traumatic brain injury is a leading cause of disability and mortality. Finite element-based head models are promising tools for enhanced prediction, mitigation prevention. The reliability such depends heavily on adequate representation the brain-skull interaction. Nevertheless, interface has been largely simplified in previous three-dimensional without accounting fluid behaviour cerebrospinal (CSF) its mechanical interaction with skull. In this study, previously developed model modified as...
Biomechanical studies of concussions have progressed from qualitative observations head impacts to physical and numerical reconstructions, direct impact measurements, finite element analyses. Supplementary a previous study, which investigated maximum principal strain, the current study used detailed model simulate unhelmeted concussion no-injury evaluate effectiveness various tissue-level brain injury predictors: strain rate, product cumulative damage measure, von Mises stress, intracranial...
Although concussion is one of the greatest health challenges today, our physical understanding cause injury limited. In this Letter, we simulated football head impacts in a finite element model and extracted most dominant modal behavior brain's deformation. We showed that deformation sensitive low frequency regimes close to 30 Hz, discovered for subconcussive impacts, dynamics brain dominated by single global mode. show existence localized modes multimodal as hyperviscoelastic medium. This...
Computational models incorporating anisotropic features of brain tissue have become a valuable tool for studying the occurrence traumatic injury. The deformation in direction white matter tracts (axonal strain) was repeatedly shown to be an appropriate mechanical parameter predict However, when assessing reliability axonal strain injury population, it is important consider predictor sensitivity biological inter-subject variability human brain. present study investigated response 485...
The purpose of the present study was to evaluate variability in annual head injury incidence rate Sweden from 1987 2000. It hypothesized that would decrease over time due a variety primary preventive strategies have been introduced Swedish society. We used Hospital Discharge Register at National Board for Health and Welfare codes 800-804, 850-854 ICD9 system S2.0-S2.9, S6.0-S6.9 ICD-10 system. evaluated patterns age, gender, external cause (E-code), type injury, length hospital stay, trends...