A5009928548- Gut microbiota and health
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- Clostridium difficile and Clostridium perfringens research
- Metabolism, Diabetes, and Cancer
- Kruppel-like factors research
- Click Chemistry and Applications
- Gastrointestinal motility and disorders
- Biomarkers in Disease Mechanisms
- Nanocluster Synthesis and Applications
- Synthetic Organic Chemistry Methods
- Advanced Nanomaterials in Catalysis
- Food composition and properties
- Epigenetics and DNA Methylation
- Gold and Silver Nanoparticles Synthesis and Applications
- Hippo pathway signaling and YAP/TAZ
University of Pavol Jozef Šafárik
2021-2024
A novel series of proflavine ureas, derivatives 11a–11i, were synthesized on the basis molecular modeling design studies. The structure ureas was obtained from pharmacological model, parameters which determined studies structure-activity relationship previously prepared bearing n-alkyl chains. lipophilicity (LogP) and changes in standard entropy (ΔS°) urea models, input using quantum mechanics cheminformatics. anticancer activity evaluated against NCI-60 human cancer cell lines. azepyl 11b,...
Transplantation of faecal microbiota (FMT) is generally considered a safe therapeutic procedure with few adverse effects. The main factors that limit the spread use FMT therapy for idiopathic inflammatory bowel disease (IBD) are necessity minimising risk infection and transfer another disease. Obtaining animal model UC (ulcerative colitis) by exposure to DSS (dextran sodium sulphate) depends on many significantly affect result.
The erythropoietin receptor (EPOR) is a transmembrane type I with an essential role in the proliferation and differentiation of erythroid progenitors. Besides its function during erythropoiesis, EPOR expressed has protective effect various non-hematopoietic tissues, including tumors. Currently, advantageous aspect related to different cellular events still under scientific investigation. well-known on cell proliferation, apoptosis differentiation, our integrative functional study revealed...