Ján Fedačko

ORCID: 0000-0002-4940-0393
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About
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Research Areas
  • Nutritional Studies and Diet
  • Cardiovascular Function and Risk Factors
  • Lipoproteins and Cardiovascular Health
  • Blood Pressure and Hypertension Studies
  • Fatty Acid Research and Health
  • Cardiovascular Disease and Adiposity
  • Heart Failure Treatment and Management
  • Heart Rate Variability and Autonomic Control
  • Diet and metabolism studies
  • Consumer Attitudes and Food Labeling
  • Cardiac Imaging and Diagnostics
  • Coenzyme Q10 studies and effects
  • Cardiac Health and Mental Health
  • Obesity, Physical Activity, Diet
  • Nutrition, Genetics, and Disease
  • Dietary Effects on Health
  • Antioxidant Activity and Oxidative Stress
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Liver Disease Diagnosis and Treatment
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cardiac pacing and defibrillation studies
  • Cardiovascular Health and Risk Factors
  • Hydrogen's biological and therapeutic effects
  • Cardiovascular Health and Disease Prevention

University of Pavol Jozef Šafárik
2015-2024

Comenius University Bratislava
2023

Era's Lucknow Medical College and Hospital
2022

University of Kufa
2022

University Research Co (United States)
2022

Vitenparken
2020

Fukuoka University
2018

Univerzitná Nemocnica Louisa Pasteura
2014-2017

Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain. Download PDF the Research Summary. We conducted double-blind, randomized, placebo-controlled trial involving patients who were unable or unwilling to take statins owing unacceptable ("statin-intolerant" patients) had, at high risk for, disease. The assigned...

10.1056/nejmoa2215024 article EN New England Journal of Medicine 2023-03-04

Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary syndromes (ACS) are substantial contributors to morbidity mortality across Europe. Much of these diseases burden is modifiable, in particular by lipid-lowering therapy (LLT). Current guidelines based on the sound premise that with respect low density lipoprotein cholesterol (LDL-C), "lower better for longer", recent data have strongly emphasized need also "the earlier better". In addition statins, which been...

10.1016/j.phrs.2021.105499 article EN cc-by-nc-nd Pharmacological Research 2021-02-17

Background There are few studies detailing the prevalence of prehypertension and hypertension in India.Methods Men women, over 25 years age were included. After completion a dietitian-administered questionnaire followed evaluation by physician, physical examination blood pressure measurement. Cross-sectional survey screened 6940 subjects, (3507 men (M), 3433 women (W): 1993-96) from cities located five corners India (Kolkata, n = 900; Nagpur, 894; Mumbai, 1542; Thiruanantpuram, 1602;...

10.1080/ac.66.1.2064964 article EN Acta Cardiologica 2011-02-01

Summary The pharmacokinetics of oral rivaroxaban are highly predictable and only affected to a limited extent by bodyweight; therefore, dose adjustments for bodyweight not required. However, this raises concerns among physicians potential under- or overdosing. This substudy the randomised EINSTEIN DVT PE trials, which compared with enoxaparin/vitamin K antagonist (VKA) therapy, aimed determine incidence major bleeding in patients low recurrent venous thromboembolism (VTE) high during...

10.1160/th16-02-0087 article EN Thrombosis and Haemostasis 2016-01-01

Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary syndromes (ACS) are substantial contributors to morbidity mortality across Europe. Fortunately, as much two thirds of this disease's burden is modifiable, in particular by lipid-lowering therapy (LLT). Current guidelines based on the sound premise that, with respect low-density lipoprotein cholesterol (LDL-C), "lower better for longer", recent data have strongly emphasised need also "the earlier better". In addition...

10.1007/s40265-024-02105-5 article EN cc-by-nc Drugs 2024-11-04

The objective of this study was to evaluate the possible benefits coenzyme Q 10 and selenium supplementation administered patients with statin-associated myopathy (SAM). Sixty eligible entered pilot study. Laboratory examination (CoQ10, selenium, creatin kinase) intensity SAM (visual scale) were performed at baseline, after 1 month, end month 3. Plasma levels CoQ10 increased from 0.81 ± 0.39 3.31 1.72 μmol/L in active group treated by CoQ10, compared placebo (p = 0.001). Also, symptoms...

10.1139/cjpp-2012-0118 article EN Canadian Journal of Physiology and Pharmacology 2012-12-05

Fibromyalgia Syndrome (FMS) is a complex, chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, cognitive difficulties, and variety of other symptoms. Despite being one the most common pain conditions, affecting millions worldwide, FMS remains poorly understood frequently misdiagnosed. This paper aims to delve deeper into multifaceted nature fibromyalgia, challenging perception that it merely syndrome. The pathophysiology involves combination...

10.54660/ijmbhr.2025.6.1.74-79 article EN International Journal of Medical and All Body Health Research 2025-01-01

Many studies have highlighted the important role of PCSK9 in development cardiometabolic changes and its possible function as a biomarker myocardial infarction or ischemic heart disease. This study aimed to determine relationship between circulating levels subclinical vascular group low risk patients without manifest cardiovascular diseases.In this study, 120 healthy patients, free diseases, diabetes mellitus, lipid-lowering therapy, were divided into three groups based on BMI: normal weight...

10.1007/s40119-017-0092-8 article EN cc-by-nc Cardiology and Therapy 2017-06-16

There is evidence that both carnitine and coenzyme Q 10 (Co Q), which are important for the functioning of myocardial mitochondria, deficient in patients with congestive heart failure, association increased pro-inflammatory cytokines. It possible supplementation ubiquinol L-carnitine may protect these by decreasing inflammation.In a randomized, double-blind, placebo-controlled trial, effects carni Q-gel (2250 mg/d 270 hydrosoluble ubiquinol) were examined 12 weeks. Thirty-one failure...

10.2143/ac.62.4.2022278 article EN Acta Cardiologica 2007-07-31

The prevalence and mortality due to multifactorial polygenic diseases; hypertension, coronary artery disease (CAD), diabetes cancer vary depending upon genetic susceptibility environmental precursors because they have identifiable mendelian subsets.Rapid changes in diet lifestyle, may influence heritability of the variant phenotypes that are dependent on nutraceutical or functional food supplementation for their expression.It is possible recognize interaction specific nutraceuticals, with...

10.2174/1876396000902010070 article EN The Open Nutraceuticals Journal 2009-04-10

Introduction: Diabetes mellitus has become a global public health problem, characterized by increased intake of western style diets and decline in physical activities which are pro-inflammatory. Food diversity, nutrient profile, glycemic index lower content salt sugar Tran’s fat an important consideration for healthy anti-inflammatory diet may be advised prevention diabetes cardiovascular diseases (CVDs). This clinical observation aims to examine the effects millets based functional food...

10.15406/mojph.2020.09.00318 article EN cc-by-nc MOJ Public Health 2020-02-12

The Seven Country study showed that traditional Japanese diet and Mediterranean diets are protective against cardiovascular diseases (CVDs). is considered the healthiest because it provides highest longevity health to Japanese. DASH style also healthy diets, although, possible Indo-Mediterranean may provide better effects among patients with CVDs, compared other diets. concept of type was developed, after examining its role in prevention CVDs India, value which confirmed by a landmark from...

10.20944/preprints202201.0373.v1 preprint EN 2022-01-25

The study aims to examine the effects of coenzyme Q10, (a bioenergetic antioxidant), on indexes left ventricular remodeling, oxidative damage, and angiotensin-converting enzyme (ACE) level after acute myocardial infarction (AMI) with dysfunction. In a double blind, randomized, placebo-controlled, parallel group retrospective analysis an earlier trial) in 55 patients ejection fraction <50% AMI, Q10 (120 mg/day) or placebo were studied for 24 weeks. Two-dimensional echocardiography was...

10.3390/antiox7080099 article EN cc-by Antioxidants 2018-07-25
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