A5043181544- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Cardiac Ischemia and Reperfusion
- Liver Disease and Transplantation
- Antioxidant Activity and Oxidative Stress
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Neurological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Eosinophilic Disorders and Syndromes
- Protease and Inhibitor Mechanisms
- Neonatal Respiratory Health Research
- Coenzyme Q10 studies and effects
- Vascular Anomalies and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Religious, Philosophical, and Educational Studies
University of Pavol Jozef Šafárik
2013-2025
Vitenparken
2020
Univerzitná Nemocnica Louisa Pasteura
2003-2019
University of Glasgow
2017
Uzhhorod National University
2017
University of Veterinary Medicine in Košice
2011
Semmelweis University
1998
Background: Impaired endothelial function has been associated with vascular complications in type 2 diabetes (T2D), but its role T2D-related heart failure (HF) remains indeterminate. The aim of this study was to assess selected markers T2D patients acute decompensated HF. Methods: A pilot prospective on HF requiring in-hospital admission carried out. growth factor (VEGF), intercellular adhesion molecule 1 (ICAM-1), and cell (VCAM-1) were assessed at after decongestion. Subsequently,...
Abstract Background: Statins represent a group of drugs that are currently indicated in the primary and secondary prevention cardiovascular events. Their administration can be associated with side effects insufficient reduction triacylglyceride (TAG) levels. This study aimed to assess effect triple combination statins omega-3 fatty acids coenzyme Q10 (CoQ10) on parameters atherogenesis statin effects. Methods: In this pilot randomized double-blind trial, 105 subjects who met criteria...
Many studies have highlighted the important role of PCSK9 in development cardiometabolic changes and its possible function as a biomarker myocardial infarction or ischemic heart disease. This study aimed to determine relationship between circulating levels subclinical vascular group low risk patients without manifest cardiovascular diseases.In this study, 120 healthy patients, free diseases, diabetes mellitus, lipid-lowering therapy, were divided into three groups based on BMI: normal weight...
Intestinal ischemia-reperfusion injury (IIRI) is a life-threatening condition requiring prompt medical intervention. Tetramethylpyrazine (TMP) biologically active alkaloid isolated from Ligusticum wallichii. Previously, it was shown that TMP causes vasodilatation and inhibition of platelet aggregation as well exhibits significant antioxidant effects. Therefore, the aim present study to evaluate possible therapeutic effects in prevention IIRI. Wistar rats (n = 80) were randomly divided into...
Abstract Background More than 64 million patients with heart failure (HF) are burdened poor quality of life, frequent hospitalizations, and high readmission rates. While HF reduced ejection fraction (HFrEF) accounts for approximately half these patients, there is currently no effective tool performing cost-effective reliable early-stage screening. For this purpose, we derived cross-validated a machine learning (ML) based system capable identifying HFrEF on analysis the photoplethysmographic...
<b>Aims:</b> Many patients with idiopathic pulmonary fibrosis (IPF) have a delay in diagnosis and thus also treatment. We investigated whether such influenced survival treatment response to pirfenidone nitedanib. <b>Methods:</b> The retrospective study used data from European Multipartner IPF registry (EMPIRE). 1170 were divided the 2 groups: 1) diagnosed within (824) 2) after 12 months (346) initiation of symptoms. groups did not differ demographic data, proportion treated antifibrotic...
Different pathological affections of the small intestine cause corresponding morphological and functional changes. The present study was aimed to assess intestinal trehalase activities during ischemia following reperfusion, correlate them with changes determine whether could be used as a biochemical marker ischemia, - reperfusion injury. Wistar rats, randomly divided into 5 experimental groups (IR) (each n=15), were subjected one hour mesenteric followed by 0, 1, 4, 12 24 hours reperfusion....
Currently, just a few major parameters are used for cardiovascular (CV) risk quantification to identify many of the high-risk subjects; however, they leave lot them with an underestimated level CV which does not reflect reality.The submitted study design Kosice Selective Coronarography Multiple Risk (KSC MR) Study will use computer analysis coronary angiography results admitted patients along broad patients' characteristics based on questionnaires, physical findings, laboratory and other...
Aim: Evaluation of role supplementation omega-3 polyunsaturated fatty acids on endothelial function in patients with metabolic syndrome. 
 Methods: Total 80 syndrome were enrolled to two groups. We evaluated subjects before and after three-month treatment dose 2.4g daily (800mg 3 times a day) vs placebo. Using the Endo-PAT2000 device (Itamar Medical Ltd. Caesarea, Israel), reactive hyperemia index – parameter augmentation index– arterial stiffness measured. Plasmatic level glutation...
Summary Significant acute cardiovascular, metabolic, and endocrine changes have been traced to short-lasting cold water immersion (CWI); however, the long-term impact of recurrent CWI on atherogenesis, lipid parameters, fat distribution has not yet studied. The goal this study was investigate alleged protective effect. A total 35 healthy volunteers were monitored for a period 5 months during which performed under standardized conditions (three times per week 7–10 min, without neoprene...
Background . Pulmonary arterial dissection with chronic pulmonary hypertension as its major cause is a very rare but life-threatening condition. In most cases the main trunk affected site usually without involvement of branches. Segmental or lobar artery extremely rare. Case Presentation We report unique case left lower lobe in 70-year-old male, confirmed hypertension. To confirm MDCT angiography was used. Multiplanar reformation (MPR) images sagittal, coronal, oblique and curved projections...
Cíl / Základní informace: Vysoké riziko rekurence ischemické cévní mozkové příhody (iCMP) během prvních 14 dnů po první atace odpovídajících symptomů při aterosklerotické stenóze karotidy dalo podnět k revizi načasování karotické endarterektomie (carotid endarterectomy, CEA) u symptomatických pacientů. Nyní je často diskutována otázka, zda lze doporučit provedení urgentní CEA do 72 hodin od nástupu příznaků CMP neurologicky nestabilních V tomto článku hodnotíme přínos akutní fáze...
Most patients with IPF have comorbidities, which affect functional status, quality of life and survival. Our study aims are to analyze comorbidities in a series 1210 from the EMPIRE registry (European Multipartner registry). Comorbidities were noted 85.6% (1036pts), one 23.5%, 2 23.0% 3 or more 53.5%. Median age at diagnosis was 67.2 years (range 50.0-82.2). Male female ratio 68.8%:31.2%. The most frequent cardiovascular diseases 68.1% (824pts), significantly than general population (GP)...
Abstract Diagnosis of bowel diseases is often difficult and time consuming since it not always possible to obtain adequate information by the conventional diagnostic methods set up a diagnosis exclude nongastrointestinal causes symptoms. The aim this study was investigate structure blood serum samples patients with selected intestinal diseases. (N=35) diagnoses ( mesenteric thrombosis , inflammatory disease duodenal ulcers sepsis enterorrhagia sigmoid colon resection small intestine cancer )...
Abstract A novel approach to the study of venoms characterizes and compares venom structure genus Dendroaspis presented in this work. The complex molecular individual was defined graphically as a record synchronous fluorescence fingerprint atomic force microscopy. Simple comparison these methods mentioned above analyzed samples will immediately reveal changes each composition. Application with electrophoresis total protein concentration are new alternatives that were used for monitoring...
ABSTRACT The aim of this study was to evaluate endogenous fluorescence small intestine samples and compare them with the histopathological results. autofluorescence intestinal homogenates injury index after 1h mesenteric or portal ischemia, 1 24 hours reperfusion analysed. Our results revealed two maximum peaks on EEM. Increase accompanied significant increase intensities in both zones. Close correlation between found. Autofluorescence can be used suggesting use as a new diagnostic method injury.
Abstract Objective This study aimed to compare the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), hemopexin (Hpx), and interleukin-4 (IL-4) in patients with carotid artery atherosclerosis based on neurological symptoms plaque histopathology find association between stability symptoms. single-center included treated surgically for significant stenosis internal artery. Serum biomarkers were determined, a histopathological analysis plaques was performed. Within 70 patients,...
We present a novel method of assessing damage to the liver using fluorescence analysis hepatic mitochondria following ischaemia/reperfusion small intestine in rat model. This work is substantial importance understanding syndrome multiorgan failure after ischemia/transplantation intestine. Mitochondria were isolated from six sample groups that had undergone three different experimental treatments: control group; treatment with ischaemia followed by reperfusion (IRx); and, one hour transplant...