A5061252302- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Aortic Disease and Treatment Approaches
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Metal complexes synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- Organ Transplantation Techniques and Outcomes
- Intensive Care Unit Cognitive Disorders
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Advanced Breast Cancer Therapies
- TGF-β signaling in diseases
- Cardiac Ischemia and Reperfusion
- Circular RNAs in diseases
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
University of Pavol Jozef Šafárik
2016-2025
University of Veterinary Medicine in Košice
2011-2019
Research Institute of Inorganic Chemistry
2014
Abstract Background Leucine‐rich repeat kinase 2 ( LRRK2 ) p.L1795F variant was proposed as a genetic risk factor for Parkinson's disease (PD). However, its prevalence, phenotype, and origin remain unknown. Objective The aim to evaluate the frequency phenotype of in early‐onset PD (EOPD) familial compared healthy controls (HC) Central Europe. Methods Whole‐exome sequencing used screen 219 EOPD patients Europeans HC. Sanger assessed segregation. Detailed clinical evaluated all positive...
Inadequate angiogenesis of endometriotic implants stimulated by the inflammatory microenvironment in uterine region leads to development gynecological diseases, which significantly reduce fertility and vitality young women. Angiogenic processes are controlled factors whose activities regulated at gene level reactive oxygen species (ROS), hypoxia-induced (HIFs), zinc-finger proteins (ZnFs) or posttranscriptionally via non-coding RNAs. The cooperation these is responsible for manifestation...
Post-cardiac surgery delirium is a severe complication. The circadian rhythm of melatonin secretion has been shown to be altered postoperatively.It was hypothesized that restoring normal sleeping patterns with substance capable resynchronizing such as exogenous administration may possibly reduce the incidence postoperative delirium.This paper represents prospective clinical observational study. Two consecutive groups 250 patients took part in Group A control group and B group. In B, received...
Abstract Background In recent years, the endometriosis has overcome a noteworthy renaissance in recognition of its potential. certain patients, demonstrable malignant progression ectopic foci leading to development ovarian cancer is seen. The knowledge overthrow background into associated paramount importance for selection patients at risk. goal presented study was review potential and specify predictive factors cancer. Altogether 189 were included study. Conventional cytogenetics as well...
Cohesin is a multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms remains enigmatic. Here, we show two populations functionally distinct cohesin using combination genomics single-locus specific DNA-FISH analysis. Chromatin bound at loading sites co-localizes with Pds5 Eso1 resulting in stable cohesion. In contrast, independent...
Predmet výskumu: Delírium po kardiochirurgických operáciách predstavuje závažnú komplikáciu. Klinická štúdia mala za úlohu posúdiť včasné rizikové faktory delíria a identifikovať, ktoré z nich by mohli byť potenciálne modifikované účelom optimalizovania perioperačného manažmentu.Metodika: Pôvodná práca prospektívnu klinickú observačnú štúdiu. Štúdia pozostáva 250 sebe nasledujúcich pacientov. Operačné postupy, spôsob vedenia anestézie ako aj pooperačný manažment pacientov boli realizované...
Abstract Background: Intradialytic resistance training (IRT) protects patients’ muscle mass and functions against protein-energy wasting, malnutrition cachexia. However, the evidence of effects such an intervention in haemodialysis patients is limited not conclusive. To improve applicability interventions, we need a better understanding molecular, functional psycho-social adaptation dialysed following physical training. Therefore, aim this study to investigate IRT on lower extremity...
Abstract The innate response of melanocytes to exogenous or endogenous stress stimuli like extreme pH and temperature, metabolite oxygen deficiency a high UV dose initiates cellular response. This process activates adaptive processes minimize the negative impact stressor on pigment cell. Under physiological conditions, non-cancer cell is directed apoptosis if persists. However, malignant melanoma cells will survive persistent thanks distinct "cancerous" signaling pathways (e.g. MEK)...
Periodontitis is a chronic inflammatory disease caused by microbial dental plaque which leads to the destruction and loss of supporting tissues tooth. Microbial alone, however, not enough cause disease. The body's response plays an important role, in imbalance between pro-inflammatory anti-inflammatory effects cytokines reaction.We detected changes mRNA expression protein levels MIP-1α, metalloproteinases (MMP-2, MMP-9) contributing cascades initiation progression bone resorption periodontal...
The small intestine is an organ with very well developed immunological activity, responsible for synthesis of specific inflammatory mediators that participate in causing the systemic inflammation can occur after ischemia-reperfusion injury.The aim our work was to study mRNA expression and protein concentration cytokines IL-10 TNFα jejunal wall intestinal injury (IRI).Cytokine levels confirmed direct effect IRI on process.The results refer changes balance between pro-inflammatory...
Pathogenic variants in
Abstract The miRNA-206 and miRNA-23a play an important role in muscle tissue hypertrophy, regeneration atrophy. Both of these miRNAs have been highlighted as promising adaptation predictors; however, the available evidence on associations is inconclusive. Therefore, our aim was to assess expression levels two predictors change function during strength training physical inactivity among dialysed patients. For this purpose, 46 haemodialysis patients were monitored for 12-weeks either...