A5025144005- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organometallic Complex Synthesis and Catalysis
- Crystallography and molecular interactions
- Synthesis and characterization of novel inorganic/organometallic compounds
- Organoboron and organosilicon chemistry
- Metal complexes synthesis and properties
- Vanadium and Halogenation Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- Coordination Chemistry and Organometallics
- Crystal structures of chemical compounds
- Synthetic Organic Chemistry Methods
- Magnetism in coordination complexes
- Metal-Catalyzed Oxygenation Mechanisms
- Lanthanide and Transition Metal Complexes
- Ferrocene Chemistry and Applications
- Nonlinear Optical Materials Research
- Synthesis and Properties of Aromatic Compounds
- Organometallic Compounds Synthesis and Characterization
- Carbon dioxide utilization in catalysis
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Cyclization and Aryne Chemistry
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2015-2025
Charles University
2016-2025
J. Selye University
2012-2024
Česká Zbrojovka (Czechia)
2020
Czech Academy of Sciences
1996-2016
Comenius University Bratislava
2014-2015
University of St Andrews
2009
University of Edinburgh
2009
Research Institute of Inorganic Chemistry
2009
Leipzig University
2007-2008
Two new alkaline earth metal-organic frameworks (AE-MOFs) containing Sr(II) (
A series of helical quinolizinium salts were prepared utilizing Rh-catalyzed [2+2+2]cyclotrimerization and C-H activation processes as the crucial synthetic steps. The cyclotrimerization appropriately substituted diynes with trimethylsilylethyne under conditions provided 1-arylisoquinolines in up to 61% isolated yields. Their activation/annulation various aryl alkyl disubstituted alkynes gave rise [7]-helical high yields (up 93%). Enantioselective was also tried asymmetric induction 62% ee....
The fascinating feature of metal-organic frameworks is that they can respond to external stimuli, unlike other inorganic materials. This corresponds the framework's flexibility, which originates with long-range crystalline order framework accompanied by cooperative structural transformability. We have synthesized a novel comprised Cu(I) nodes pyrazine linkers and benzene-1,3,5-tricarboxylate acting as template anions, named CUCAM-1 [Cu(Py)2(BTC)]n. In presence polar solvent systems,...
Thermolysis of bis(tetramethylcyclopentadienyl)-stabilized titanium(III) compounds (C5HMe4)2TiR (R = Me (2), Ph (3)) yields, in marked contrast with the bis(pentamethylcyclopentadienyl) analog, dimeric product [(C5HMe4)(μ-η1:η5-C5Me4)Ti]2 (4), a bridging metalated tetramethylcyclopentadienyl ligand. The hydride (C5HMe4)2TiH (5), synthesized by hydrogenolysis 2 or 3, reacts N2 to form dinuclear Ti(II) dinitrogen compound [(C5HMe4)2Ti]2N2 (8). Under dynamic vacuum, complex 8 loses ligand give...
The present study reports the asymmetric cyclization of enals with vinylcyclopropane azlactones efficiently catalyzed by combination achiral Pd(0) complexes and chiral secondary amines. Corresponding spirocyclic were produced in high yields moderate diastereoselectivities excellent enantioselectivities. This protocol provides an efficient easily-performed route to scaffolds, densely functionalized cyclopentanes containing quaternary carbon centers.
A series of four novel microporous alkaline earth metal-organic frameworks (AE-MOFs) containing methanetetrabenzoate linker (MTB) with composition {[Ca4(μ8-MTB)2]·2DMF·4H2O} n (UPJS-6), {[Ca4(μ4-O)(μ8-MTB)3/2(H2O)4]·4DMF·4H2O} (UPJS-7), {[Sr3(μ7-MTB)3/2]·4DMF·7H2O} (UPJS-8) and {[Ba3(μ7-MTB)3/2(H2O)6]·2DMF·4H2O} (UPJS-9) (UPJS = University Pavol Jozef Safarik) have been successfully prepared characterized. The framework stability thermal robustness materials were investigated using...
A novel microporous metal-organic framework, {[Pb4(μ8-MTB)2(H2O)4]·5DMF·H2O}n (1; MTB = methanetetrabenzoate and DMF N,N'-dimethylformamide), was successfully synthesized by a solvothermal reaction structurally characterized single-crystal X-ray diffraction. The framework exhibits unique tetranuclear [Pb4(μ3-COO)(μ2-COO)6(COO)(H2O)4] secondary building unit (SBU). combination of the SBU with tetrahedral symmetry results in three-dimensional network structure, one-dimensional jarlike cavities...
A facile silver(I)-catalyzed reaction of benzothiazol-2(3H)-ones with NaNO2, or using AgNO2 directly, enables a single-step transformation to the corresponding benzo[1,2,3]thiadiazoles in moderate excellent yields, wide functional group compatibility. It can also be performed one-pot manner from readily available 2-halobenzothiazoles. This intriguing involving an atom replacement S,N-heteroarene ring thus provides rapid access isobenzothiadiazoles (while avoiding usage unstable precursors)...
The singly tucked-in permethyltitanocene 1 reacts with an excess of internal alkynes to give the 1:1 adducts 3a−c,f−i, arising from insertion alkyne triple bond into titanium−methylene bond. Only simplest species, 2-butyne, inserted two molecules known compound 2; however, at a stoichiometric ratio adduct 3j was also smoothly formed. 1,4-Disubstituted conjugated diynes CMe3 or SiMe3 substituents reacted in same way by only one 3d,e, respectively. dimethylsilylene-bridged dialkynes...
Copper(II)-catalyzed C–H/C–H coupling of dipolar 2-H-benzothiazoles end-capped with triphenylamine moieties affords highly fluorescent 2,2′-bibenzothiazoles quadrupolar (D-π-A-π-D) architecture displaying large two-photon absorption (TPA) cross sections (543–1252 GM) in the near-infrared region. The notably higher TPA performance as compared to π-systems a widely used 2,2′-bipyridine core, along ease synthesis and chelating N^N ability, makes title biheteroaryl platform an attractive...
Abstract The enantioselective synthesis of chiral [7]‐helical dispirodihydro[2,1‐ c ]indenofluorenes (DSF‐IFs) was achieved for the first time in good yields with high er values ( up to 99 : 1). crucial step whole reaction sequence intramolecular [2+2+2] cycloaddition tethered triynediols indenofluorenediols, which catalyzed by a Rh/SEGPHOS® complex. Further transformations led corresponding DSF‐IFs. prepared helically DSF‐IFs combine circularly polarized luminescence (CPL) activity g lum...
We have used in situ energy dispersive synchrotron X-ray diffraction to study the crystallization of aluminum phosphate frameworks under ionothermal conditions with conventional and microwave heating. The reaction is shown follow slightly different routes depending on type heating a kinetic analysis shows that rate constant 10 times higher (1.4 compared 0.14 min−1). conventionally heated proceed by transformation SIZ-3 SIZ-4 via an intermediate, while microwave-heated forms directly....
Acylated N ‐acetyl hexosamine hemiacetals are known for their cytotoxicity. We have previously reported that cytotoxicity can be increased by replacing one or more acyloxy groups with fluorine. Herein, we present the synthesis of 4,6‐difluorinated d ‐ gluco and 4‐fluorinated galacto ‐configured hexosamine‐derived glycoconjugates organoruthenium ferrocene complexes in vitro against three cancer cell lines (A2780, SK‐OV‐3, MDA‐MB‐231) noncancerous line (HEK‐293). The attachment organometallic...
The (η6-hexamethylbenzene)dichlororuthenium(II) complexes [(η6-C6Me6)RuCl2(L)], where L = PMe3 (1), PPh3 (2), FcPPh2 (3; Fc ferrocenyl), and Hdpf (4; (η5-C5H4PPh2)Fe(η5-C5H4COOH)), were reacted with terminal alkynes (FcC⋮CH, Me3SiC⋮CH, PhC⋮CH) in the presence of NaPF6 methanol to give (η6-hexamethylbenzene)chlororuthenium(II) methoxycarbenes [(η6-C6Me6)Ru(C(OCH3)CH2R)Cl(L)]PF6 (L/R PMe3/Fc (1a), PPh3/Fc (2a), FcPPh2/Fc (3a), FcPPh2/H (3b), FcPPh2/Ph (3c), Hdpf/Fc (4a), Hdpf/H (4b), Hdpf/Ph...
Reduction of [ZrCl2{η5-C5Me4(SiMe3)}2] (1) with excess magnesium in tetrahydrofuran affords a mixture the monomeric zirconocene hydride [ZrH{η1:η5-C5Me4(SiMe2CH2)}{η5-C5Me4(SiMe3)}] (2) and dimeric, tetranuclear Zr(III)− Zr(IV)−magnesium complexes 3 4, respectively. In presence bis(trimethylsilyl)ethyne (btmse), similar reduction yields η2-alkyne complex [Zr{η5-C5Me4(SiMe3)}2(η2-btmse)] (5) as major product compounds 2−4 minor impurities. Upon thermolysis under vacuum, 5 undergoes 2-fold...
Abstract Diethyl [1′‐(diphenylphosphanyl)ferrocenyl]phosphonate ( 1 ) was synthesised by stepwise metallation/functionalisation of 1,1′‐dibromoferrocene and studied as a ligand for palladium( II group‐12 metals. Treatment [PdCl 2 (cod)] (cod = η :η ‐cycloocta‐1,5‐diene) with in 1:1 or 1:2 molar ratios gave, respectively, the dinuclear, chloride‐bridged complex [{Pd(μ‐Cl)Cl( ‐κ P )} ] mononuclear trans ‐[PdCl 3 ), where coordinates exclusively through phosphane function. The reactions between...
Neutral peroxovanadium(v) complexes, [VO(O2)(pca)(bpy)] (1), [VO(O2)(pca)(phen)] (2) and [VO(O2)(pic)(pcaa)(H2O)].H2O(3), were synthesized [2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), pyrazinecarboxamide (pcaa), 2-pyrazinecarboxylic (Hpca) picolinic (Hpic) acids]. Their X-ray single crystal analysis revealed a distorted pentagonal bipyramidal geometry in all complex molecules. The four "free" coordination sites of the vanadium atoms VO(eta2-O2)+ moieties 1 2 are occupied by donor two...
Ethene complexes of titanocenes [Ti(II)(η2-C2H4)(Cp′)2] for Cp′ = η5-C5Me5 (1), η5-C5Me4t-Bu (2), η5-C5Me4SiMe3 (3), and η5-C5HMe4 (4) were prepared by reduction corresponding titanocene dichlorides with magnesium in THF the presence ethene. Thermolysis 1–3 toluene solution at a maximum 100 °C resulted elimination ethane, affording cleanly doubly tucked-in compounds 5–7, respectively. Experiments 2 3 NMR tubes proved that symmetrical isomers 6a 7a formed first, these thermally isomerized to...