A5049409110- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Celiac Disease Research and Management
- Microscopic Colitis
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Digestive system and related health
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatitis Viruses Studies and Epidemiology
- Regulation of Appetite and Obesity
- Eosinophilic Esophagitis
- Drug-Induced Hepatotoxicity and Protection
- Systemic Lupus Erythematosus Research
- Gastrointestinal disorders and treatments
- Viral gastroenteritis research and epidemiology
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
- Alcohol Consumption and Health Effects
Universidade Federal de Santa Catarina
2016-2025
University of Padua
2025
Medico
2019
Hospital Heliópolis
2007-2019
Polydoro Ernani de São Thiago University Hospital
2013-2018
Ospedale Santa Maria della Misericordia di Rovigo
2017
Universidade Presidente Antônio Carlos
2016
Creative Research Enterprises (United States)
2016
Universidade do Sul de Santa Catarina
2011-2013
Universidade Federal de São Paulo
2006-2011
Abstract Background & Aims The idea of acute‐on‐chronic liver failure ( ACLF ) has emerged to identify those subjects with organ and high mortality rates. However, the absence a precise definition limited clinical application research related concept. We sought validate CLIF ‐ SOFA Score recently proposed by EASL Consortium in cohort patients admitted for acute decompensation AD cirrhosis. Methods In this prospective study, were followed during their hospital stay thirty 90‐day was...
Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and related to high mortality rates during follow-up of these individuals. We sought evaluate the diagnostic value C-reactive protein (CRP) procalcitonin (PCT) diagnosing investigate relationship between biomarkers after hospital admission. Material methods. Prospective study that included cirrhotic admitted due complications disease. The accuracy CRP PCT for diagnosis was evaluated by...
HCV infection is common among patients with end-stage renal disease (ESRD) on hemodialysis, and it has been considered an independent risk factor for mortality in this setting. Although liver biopsy ESRD useful before kidney transplantation, carries a high of complications. We sought to assess the diagnostic value noninvasive markers stage fibrosis 203 HCV-infected patients. Univariate multivariate analysis were used identify variables associated significant (METAVIR F2, F3, or F4 stages)....
Introduction. Although it is standard procedure in the evaluation of liver diseases, biopsy an invasive method subject to sampling error and intra or inter-observer variability. Thus, surrogate markers fibrosis have been proposed, with variable availability accuracy. Aim. Validate compare performance APRI FIB-4 as predictors HCV patients. Material methods. Cross-sectional study including patients HCV-RNA (+) who underwent biopsy. Significant was defined METAVIR stage ≥ 2. The diagnostic...
Direct antiviral agents (DAAs) including sofosbuvir (SOF), daclatasvir (DCV), simeprevir (SIM) and ombitasvir, paritaprevir dasabuvir were introduced 2015 in Brazil for treatment of hepatitis C virus (HCV) infection. The aims this study to assess effectiveness safety HCV with DAA real-life world a highly admixed population from Brazil. All Brazilian reference centers invited take part web-based registry, prospectively conducted by the Society Hepatology, outcomes DAAs. Data be collected...
Introduction. Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated adiponectin its clinical cirrhosis. Materials methods. This was a prospective cohort study that included 122 subjects cirrhosis who attended an outpatient clinic were initially evaluated 2012. Serum measured samples collected 2012 (adiponectin resistin) 2014 (adiponectin). Thirty healthy served as control group....
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality worldwide. The Brazilian Society Hepatology (SBH) published in 2015 its first recommendations about management HCC. Since then, new data have emerged literature, prompting governing board SBH to sponsor a single-topic meeting August 2018 São Paulo. All invited experts were asked make systematic review literature reviewing HCC subjects with cirrhosis. After meeting, all panelists gathered together for...
Introduction: The first months after the hospitalization of cirrhotic patients are considered at high risk for new complications. Knowing factors associated with early readmission in these individuals may contribute to development preventive strategies that avoid risks and costs related a hospitalization. Objective: To investigate hospitalized due acute decompensation cirrhosis. Methods: Data from each patient was during study period were followed up 90th day by telephone contact. A...
INTRODUÇÃO: A pancreatite é uma doença inflamatória que acomete o pâncreas, e pode se apresentar tanto como aguda, aguda recorrente ou crônica. define por pelo menos dois eventos de seja causas externas, pela própria anatomia do órgão. Existem diversas etiologias possíveis para essa afecção, incluem mecânicas, farmacológicas, autoimunes, disfunção esfíncter Oddi, anatômicas idiopáticas. Relatamos um caso pâncreas divisum. RELATO DE CASO: Uma mulher 19 anos refere dor em andar superior abdome...
Abstract In this Research Note, we introduce Intronomics-MIP, a snakemake-based pipeline for the automated analysis of multi-locus intron polymorphisms (MIPs) using intron-targeted amplicon sequencing. Building on established methodologies, our integrates tools such as Cutadapt, FLASH, and SeekDeep to efficiently process analyze highly variable regions. These MIPs serve powerful multiple-allelic markers, primarily useful distinguishing species, identifying cryptic disentangling species...
Abstract Aim: To assess the diagnostic value of modified cutoffs for aspartate aminotransferase to platelet ratio index (APRI) predict significant liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C (HCV) patients. Patients and Methods: This retrospective cross‐sectional study included consecutive patients with HIV/HCV co‐infection who underwent percutaneous biopsy. The accuracy APRI diagnosis (F2/F3/F4 METAVIR) was evaluated by estimating positive negative predictive values...
Serum autoantibodies such as antinuclear antibody (ANA) are frequently detected in patients with chronic hepatitis C virus (HCV) infection, but its relevance is a matter of discussion.To assess the association ANA positivity clinical and histological features, outcome antiviral therapy HCV infection.Baseline samples from treated interferon ribavirin were tested for by indirect immunofluorescence.The mean age was 48.3+/-11.1 years 56% men. Among 234 included patients, 22 (9.4%) positive ANA....
Although various studies have been published regarding the treatment of chronic hepatitis C (CHC) with peginterferon (Peg-IFN) and ribavirin, little is known real impact gender on characteristics that influence effectiveness safety antiviral for CHC patients. The objective this study was to evaluate HCV outcomes.A retrospective analytical conducted among selected carriers genotype 1, who were treated Peg-IFN alpha-2b at a dose 1.5 microg/kg or alpha-2a 180 microg/week plus ribavirin...
Abstract Acute-on-chronic liver failure (ACLF) is a condition characterized by acute decompensation of cirrhosis, associated with organ failure(s), and high short-term mortality. The microRNAs or miRNAs are small non-coding RNA molecules, stable in circulating samples such as biological fluids, the difference expression levels may indicate presence, absence and/or stage disease. We analyzed here miRNA profiling to identify potential diagnostic prognostic biomarkers for ACLF. major discovered...
Liver cirrhosis is often complicated by an immunological imbalance known as cirrhosis-associated immune dysfunction. This study aimed to investigate disturbances in circulating monocytes and dendritic cells patients with acute decompensation (AD) of cirrhosis. The sample included 39 adult cirrhotic hospitalized for AD, 29 stable (SC), 30 healthy controls (CTR). Flow cytometry was used analyze monocyte cell subsets whole blood quantify cytokines plasma samples. Cirrhotic groups showed higher...
Summary. Hepatitis C virus (HCV) infection is highly prevalent among end‐stage renal disease (ESRD) patients undergoing haemodialysis and it an important cause of morbidity mortality in this population. The aim study was to evaluate the diagnostic value YKL‐40 hyaluronic acid (HA) as noninvasive markers liver fibrosis 185 ESRD HCV‐infected patients. Significant defined METAVIR F2, F3 or F4 stages. observed 45 (24%). By univariate analysis, higher levels YKL‐40, HA, aspartate aminotransferase...
Autoantibodies are often produced during infection with chronic hepatitis C virus (HCV), but it remains controversial whether they influence the biochemical profile and histological features of this disease. Therefore, current study sought to describe these autoantibodies evaluate their impact on clinical presentation C.This cross-sectional analytical assessed patients HCV (RNA+) from October 2011 July 2012.This included 66 patients, a mean age 53.2±10.5 years. Of 60.6% were male, 54.3%...