A5027482072- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Liver Disease and Transplantation
- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- SARS-CoV-2 detection and testing
- Reproductive Health and Contraception
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Science and Education Research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Women's cancer prevention and management
- Organ Transplantation Techniques and Outcomes
- Adolescent Sexual and Reproductive Health
- Viral gastroenteritis research and epidemiology
- Genital Health and Disease
- Infectious Diseases and Tuberculosis
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Diagnosis and treatment of tuberculosis
- Blood groups and transfusion
Universidade Federal de Santa Catarina
2015-2024
Laboratory of Molecular Genetics
2024
Graduate Hospital
2024
Centro de Estudos em Psicologia da Saúde
2018
Polydoro Ernani de São Thiago University Hospital
2012-2018
Creative Research Enterprises (United States)
2016
Hospital de Clínicas de Porto Alegre
2016
Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea.
Abstract Background & Aims The idea of acute‐on‐chronic liver failure ( ACLF ) has emerged to identify those subjects with organ and high mortality rates. However, the absence a precise definition limited clinical application research related concept. We sought validate CLIF ‐ SOFA Score recently proposed by EASL Consortium in cohort patients admitted for acute decompensation AD cirrhosis. Methods In this prospective study, were followed during their hospital stay thirty 90‐day was...
Abstract We analysed human sewage located in Florianópolis (Santa Catalina, Brazil) from late October until the Brazil lockdown on early March. detected SARS-CoV-2 two samples collected independently 27 th November 2019 (5.49±0.02 log genome copies/L). Subsequent samplings were positive 4 March 2020 (coinciding with first COVID-19 case reported Santa Catalina), a RNA increase of one (6.68±0.02 Our results show that has been circulating since 2019, much earlier than Americas (21 st January 2020, USA).
Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and related to high mortality rates during follow-up of these individuals. We sought evaluate the diagnostic value C-reactive protein (CRP) procalcitonin (PCT) diagnosing investigate relationship between biomarkers after hospital admission. Material methods. Prospective study that included cirrhotic admitted due complications disease. The accuracy CRP PCT for diagnosis was evaluated by...
Abstract Objectives Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global threat and novel treatment alternatives are imperative. Herein, susceptibility to the antimicrobial zoliflodacin, currently Phase 3 randomized controlled clinical trial for gonorrhoea treatment, was investigated by screening zoliflodacin GyrB target mutations publicly available gonococcal genomes and, where feasible, determination of associated MIC. Methods The European Nucleotide Archive queried using...
During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease (TMPRSS2) were constantly under scientific spotlight, but most studies evaluated ACE2 TMPRSS2 expression levels in patients infected by SARS-CoV-2. Thus, this study aimed to evaluate of both proteins before, during, after-infection. For that, nasopharyngeal samples from 26 used measure ACE2/TMPRSS2 ex-pression via qPCR. Symptomatic presented lower before after infection than those...
Objectives The availability of point-of-care (POC) tests for infectious diseases has revolutionised the provision healthcare remote rural populations without access to laboratories. However, quality assurance POC been largely overlooked. We have evaluated use and stability dry tube specimens (DTS) External Quality Assurance (EQA) HIV syphilis screening in indigenous Amazon region Brazil. Methods All workers (HCWs) participating community-screening were trained. used DTS panels developed by...
Gonorrhoea and antimicrobial resistance (AMR) in Neisseria gonorrhoeae are major public health concerns globally. Enhanced AMR surveillance for gonococci is essential worldwide; however, recent quality-assured gonococcal Latin America, including Brazil, has been limited. Our aims were to (i) establish the first nationwide surveillance, quality assured according WHO standards, (ii) describe susceptibility of clinical isolates collected from 2015 2016 all five main regions (seven sentinel...
Neisseria gonorrhoeae antimicrobial resistance (AMR) surveillance is imperative internationally, but only eight (22.9%) countries in the WHO Region of Americas reported complete AMR data to Global Gonococcal Antimicrobial Surveillance Program (WHO GASP) 2016. Genomic studies are ideal for enhanced understanding gonococcal populations, including spread strains. To elucidate circulating lineages/sublineages, their determinants, and baseline genomic diversity among strains Brazil, we conducted...
To minimize sample dilution effect on SARS-CoV-2 pool testing, we assessed analytical and diagnostic performance of a new methodology, namely swab pooling. In this method, swabs are pooled at the time collection, as opposed to pooling equal volumes from individually collected samples. Paired analysis individual samples 613 patients revealed 94 positive individuals. Having testing reference, no false-positives or false-negatives were observed for additional 18,922 screened with (1,344 pools),...
Background Little is known about the aetiology of urethral discharge syndrome (UDS) and genital ulcer disease (GUD) in Brazil due to limited access laboratory tests treatment based mainly on syndromic approach. Objectives To update Brazilian guidelines according current scenario, first nationwide aetiological study for UDS GUD was performed. Methods Male participants with (UD) and/or (GU) reports were enrolled. Sample collection performed by 12 sentinel sites located five regions. Between...
Abstract Free-living amoebae (FLA) are widely dispersed in the environment, can cause opportunistic and non-opportunistic infections humans other animals. The aim of present study was characterize FLA obtained from air-conditioners a public hospital city Florianópolis, SC, Brazil. Fifty-four dust samples were collected air conditioners, inoculated on 1.5% non-nutrient agar, overlaid with layers Escherichia coli . Subsequently isolates axenised PYG growth medium. morphological molecular...
We field-assessed the accuracy, acceptability, and feasibility of SD BIOLINE HIV/Syphilis Duo rapid diagnostic test in three groups: pregnant women, female sex workers (FSW), men who have with (MSM). Venous blood samples collected field were compared respective gold standard methods: Treponemal Test versus FTA-abs (Wama brand) treponemal laboratory for syphilis, fourth generation Genscreen Ultra HIV Ag-Ag (Bio-Rad HIV. From a total 529 participants, 397 (75.1%) 76 (14.3%) FSW 56 (10.6%) MSM....
This paper is the result of a visit by Brazilian researchers to Ghana, with aim improving understanding relationship between traditional healers and conventional health practices, specifically in relation tuberculosis. Through this exploratory visit, group promoted Edital Pro Africa (CNPq) had an opportunity learn about, reflect on, discuss different social, economic cultural realities contexts that have led conditions forms healthcare Ghana. Besides direct social country its population, it...
This article addresses human papillomavirus (HPV) infection, this being one of the topics covered by Clinical Protocol and Therapeutic Guidelines for Comprehensive Care People with Sexually Transmitted Infections, published Brazilian Ministry Health. The have been developed based on scientific evidence validated in discussions specialists. presents epidemiological clinical aspects, as well guidelines health service managers workers about diagnosing treating people infection. theme is an...
Group B Streptococcus (GBS) is a human commensal bacterium that also associated with infection in pregnant and non-pregnant adults, neonates elderly people.The authors hypothesize knowledge of regional GBS genetic patterns may allow the use prevention treatment measures to reduce burden streptococcal disease.The aim was report genotypic diversity antimicrobial sensitivity profiles invasive, noninvasive urinary colonizing strains, evaluate relationships between these findings.The study...
Abstract Aim: To investigate serum levels of tumor markers in patients with rheumatoid arthritis (RA) and their association disease activity or the presence cancer. Method: We performed an observational cohort study including 100 RA control subjects. Serum carcinoembryonic antigen (CEA), cancer (CA) 125, CA 19–9 15–3 were evaluated along clinical laboratorial data. Association tests between parameters performed. Patients abnormal submitted to further investigation, chest X‐ray, colonoscopy,...
Drug resistance is a global threat and one of the main contributing factors to tuberculosis (TB) outbreaks. The goal this study was analyse molecular profile multidrug-resistant TB (MDR-TB) in state Santa Catarina southern Brazil. Fifty-three MDR Mycobacterium clinical isolates were analysed by spoligotyping partial region rpoB gene, which associated with rifampicin (RMP-R), sequenced. Some also distinguished their mycobacterial interspersed repetitive units (MIRU). S531L most prevalent...
Syphilis is a sexually and vertically transmitted infection caused by the bacteria Treponema pallidum for which there are few proven alternatives to penicillin treatment. For pregnant women infected with syphilis, only WHO-recommended treatment that will treat mother cross placenta unborn infant prevent congenital syphilis. Recent shortages, national level stockouts as well other barriers use call urgent identification of alternative therapies syphilis.This prospective, randomized,...